Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Norimitsu Hariguchi"'
Autor:
Tomohiro Sasaki, Hirota Kuniko, Shashikant Srivastava, Tawanda Gumbo, Moti L. Chapagain, Yusuke Inoue, Makoto Matsumoto, Lawrence Geiter, Jeffrey Hafkin, Devyani Deshpande, Norimitsu Hariguchi, Yongge Liu, Xiaofeng Wang, Alexander Berg, Suresh Mallikaarjun
Publikováno v:
Antimicrobial Agents and Chemotherapy
Pharmacokinetic (PK) and pharmacodynamic (PD) analyses were conducted to determine the cumulative fraction of response (CFR) for 100 mg twice-daily (BID) and 200 mg once-daily (QD) delamanid in patients with multidrug-resistant tuberculosis (MDR-TB),
Autor:
Motohiro Itotani, Makoto Matsumoto, Izuru Nakamura, Ohba Yoshio, Toshio Shinohara, Yohei Hayashi, Norimitsu Hariguchi, Shunpei Ishikawa, Miki Matsuba, Yoshikazu Kawano, Yoshikazu Haraguchi, Yukitaka Uematsu, Xiuhao Chen, Mamoru Fujiwara, Ryuki Kitamoto, Hiroshi Shimizu, Isao Takemura
Publikováno v:
Antimicrobial Agents and Chemotherapy
There is an urgent need for new, potent antituberculosis (anti-TB) drugs with novel mechanisms of action that can be included in new regimens to shorten the treatment period for TB. After screening a library of carbostyrils, we optimized 3,4-dihydroc
Publikováno v:
Tuberculosis (Edinburgh, Scotland). 108
Delamanid, a bicyclic nitroimidazooxazole, is effective against M. tuberculosis. Previous studies have shown that resistance to a bicyclic nitroimidazooxazine, PA-824, is caused by mutations in an F420-dependent bio-activation pathway. We investigate
Autor:
Makoto Matsumoto, Ryota Kasahara, Yoshiteru Oshima, Seiko Horoiwa, Norimitsu Hariguchi, Haruhisa Kikuchi
Publikováno v:
European Journal of Medicinal Chemistry. 76:10-19
Febrifugine, a quinazoline alkaloid isolated from Dichroa febrifuga roots, shows powerful antimalarial activity against Plasmodium falciparum. Although the use of ferifugine as an antimalarial drug has been precluded because of its severe side effect
Publikováno v:
Tuberculosis. 110:122
Autor:
Karl Harlos, Bastien Touquet, Amit Sharma, Haruhisa Kikuchi, V. Jain, Yoshiteru Oshima, Manickam Yogavel, Fabienne Tacchini-Cottier, Rajiv S. Jumani, Preeti Goel, Norimitsu Hariguchi, Makoto Matsumoto, Mohamed-Ali Hakimi, Christopher D. Huston
Publikováno v:
Structure. 25:1495-1505.e6
Developing anti-parasitic lead compounds that act on key vulnerabilities are necessary for new anti-infectives. Malaria, leishmaniasis, toxoplasmosis, cryptosporidiosis and coccidiosis together kill >500,000 humans annually. Their causative parasites
Autor:
Kenji Tani, Hiroya Tada, Luping Huang, Fumitaka Ogushi, Norimitsu Hariguchi, Tetsuya Kawano, Saburo Sone
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 161:1636-1642
CD13/aminopeptidase N (E.C.3.4.11.2) is an ectoenzyme located in the outer membrane of a variety of cells. Because aminopeptidase expression was shown to be upregulated by a Th1-related cytokine, IFN-gamma, we examined here the significance of CD13/a
Autor:
Atsuhiko Shinmyo, Takuo Yamamoto, Yulius Yulianto Setiady, Norimitsu Hariguchi, Masami Sekine, Hiroshi Kouchi
Publikováno v:
The Plant Journal. 8:949-957
Three cyclin cDNA clones (Ntcyc25, Ntcyc27, Ntcyc29) have been isolated from tobacco (Nicotiana tabacum) using the PCR cloning method. The encoded Ntcyc cyclins were highly homologous to mitotic cyclins. In synchronized tobacco suspension cultured ce
Publikováno v:
Infection and immunity. 77(5)
We have previously shown that a recombinant baculovirus that displaysPlasmodium bergheicircumsporozoite protein (PbCSP), a homolog of the leading human malaria vaccine candidate, on the viral envelope protected 60% of mice againstP. bergheiinfection.
Autor:
Seiko Horoiwa, Norimitsu Hariguchi, Ryota Kasahara, Keisuke Yamamoto, Makoto Matsumoto, Haruhisa Kikuchi, Shingo Hirai, Yoshiteru Oshima
Publikováno v:
Journal of medicinal chemistry. 49(15)
Febrifugine (1), a quinazoline alkaloid, isolated from Dichroa febrifuga roots, shows powerful antimalarial activity against Plasmodium falciparum. The use of 1 as an antimalarial drug has been precluded because of side effects, such as diarrhea, vom