Enhanced transcriptional heterogeneity mediated by NF-κB super-enhancers.

Autor: Johannes N Wibisana, Takehiko Inaba, Hisaaki Shinohara, Noriko Yumoto, Tetsutaro Hayashi, Mana Umeda, Masashi Ebisawa, Itoshi Nikaido, Yasushi Sako, Mariko Okada

Publikováno v: PLoS Genetics, Vol 18, Iss 6, p e1010235 (2022)

The transcription factor NF-κB, which plays an important role in cell fate determination, is involved in the activation of super-enhancers (SEs). However, the biological functions of the NF-κB SEs in gene control are not fully elucidated. We invest

Externí odkaz: https://doaj.org/article/fb708160723745468d1971567fa785c1

Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN

Autor: Kanako Shimizu, Satoru Yamasaki, Maki Sakurai, Noriko Yumoto, Mariko Ikeda, Chiemi Mishima-Tsumagari, Mutsuko Kukimoto-Niino, Takashi Watanabe, Masami Kawamura, Mikako Shirouzu, Shin-ichiro Fujii

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Granzyme A (GzmA), together with perforin, are well-known for their cytotoxic activity against tumor or virus-infected cells. In addition to this cytotoxic function, GzmA stimulates several immune cell types and induces inflammation in the absence of

Externí odkaz: https://doaj.org/article/21f69a4dc1de49c8bbf8bb671bd36d5c

Topological analysis of MAPK cascade for kinetic ErbB signaling.

Autor: Takashi Nakakuki, Noriko Yumoto, Takashi Naka, Mikako Shirouzu, Shigeyuki Yokoyama, Mariko Hatakeyama

Publikováno v: PLoS ONE, Vol 3, Iss 3, p e1782 (2008)

Ligand-induced homo- and hetero-dimer formation of ErbB receptors results in different biological outcomes irrespective of recruitment and activation of similar effector proteins. Earlier experimental research indicated that cells expressing both EGF

Externí odkaz: https://doaj.org/article/5272f06bc08e467b90d35b5ce856060b

Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN

Autor: Mikako Shirouzu, Mutsuko Kukimoto-Niino, Satoru Yamasaki, Maki Sakurai, Chiemi Mishima-Tsumagari, Noriko Yumoto, Takashi Watanabe, Shin-ichiro Fujii, Masami Kawamura, Mariko Ikeda, Kanako Shimizu

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)

Granzyme A (GzmA), together with perforin, are well-known for their cytotoxic activity against tumor or virus-infected cells. In addition to this cytotoxic function, GzmA stimulates several immune cell types and induces inflammation in the absence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249178220981cd80e488ed8b78b0cb66
https://pubmed.ncbi.nlm.nih.gov/31293597

Transcriptionally inducible Pleckstrin homology-like domain family A member 1 attenuates ErbB receptor activity by inhibiting receptor oligomerization

Autor: Kazunari Iwamoto, Yasushi Sako, Koichi Takahashi, Rieko Ohki, Alex von Kriegsheim, Boris N. Kholodenko, Mariko Okada-Hatakeyama, Shigeyuki Magi, Michio Hiroshima, Noriko Yumoto, Takeshi Nagashima, Shuhei Kimura, Natalia Volinsky, Amaya Garcia-Munoz

Publikováno v: Magi, S, Iwamoto, K, Yumoto, N, Hiroshima, M, Nagashima, T, Ohki, R, Garcia-Munoz, A, Volinsky, N, Von Kriegsheim, A, Sako, Y, Takahashi, K, Kimura, S, Kholodenko, B N & Okada-Hatakeyama, M 2017, ' Transcriptionally inducible Pleckstrin homology-like domain family A member 1 attenuates ErbB receptor activity by inhibiting receptor oligomerization ', Journal of Biological Chemistry . https://doi.org/10.1074/jbc.M117.778399
Journal of Biological Chemistry

Feedback control is a key mechanism in signal transduction, intimately involved in regulating the outcome of the cellular response. Here we report a novel mechanism by which PHLDA1, Pleckstrin homology-like domain, family A, member 1, negatively regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8fc15d0798c97babdbbd7fe2462119
https://hdl.handle.net/20.500.11820/11a92bd9-7985-4557-9a6e-cfa32d261624