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Publikováno v:
Bulletin of the Chemical Society of Japan. 70:477-482
Both enantiomers of 1-methoxybicyclo[2.2.2]oct-5-en-2-ones were prepared in more than 80%ee on the basis of a chemoenzymatic reaction sequence. The optical resolution was achieved by the enantioselective hydrolysis of chloroacetyl esters 1-methoxybic
Publikováno v:
Bulletin of the Chemical Society of Japan. 70:1919-1921
The treatment of a bicyclo[3.2.1]oct-6-en-2-one (3) with Amberlyst® (H-15) in boiling benzene gave a mixture of bicyclo[3.2.1]oct-3-en-2-one (5) and bicyclo[2.2.2]oct-5-en-2-one (6). The ratio of 5 to 6 was influenced by the substituent at the C-1 p