Výsledky vyhledávání - "Noriko Y. Hansen"

Akademický článek

Topoisomerase 1 Activity Is Reduced in Response to Thermal Stress in Fruit Flies and in Human HeLa Cells

Autor: Trine Juul-Kristensen, Josephine Geertsen Keller, Kathrine Nygaard Borg, Noriko Y. Hansen, Amalie Foldager, Rasmus Ladegaard, Yi-Ping Ho, Volker Loeschcke, Birgitta R. Knudsen

Publikováno v: Biosensors, Vol 13, Iss 11, p 950 (2023)

In the modern world with climate changes and increasing pollution, different types of stress are becoming an increasing challenge. Hence, the identification of reliable biomarkers of stress and accessible sensors to measure such biomarkers are attrac

Externí odkaz: https://doaj.org/article/65620ff904324773b6aadae86a7d5fc8

Zobrazit plný text záznamu

Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation

Autor: Josephine Geertsen Keller, Kirstine Mejlstrup Hymøller, Maria Eriksen Thorsager, Noriko Y Hansen, Jens Uldum Erlandsen, Cinzia Tesauro, Anne Katrine W Simonsen, Anne Bech Andersen, Kamilla Vandsø Petersen, Lise Lolle Holm, Magnus Stougaard, Brage Storstein Andresen, Peter Kristensen, Rikke Frøhlich, Birgitta R Knudsen

Publikováno v: Keller, J G, Hymøller, K M, Thorsager, M E, Hansen, N Y, Erlandsen, J U, Tesauro, C, Simonsen, A K W, Andersen, A B, VandsøPetersen, K, Holm, L L, Stougaard, M, Andresen, B S, Kristensen, P, Frøhlich, R & Knudsen, B R 2022, ' Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation ', Nucleic Acids Research, vol. 50, no. 11, pp. 6332-6342 . https://doi.org/10.1093/nar/gkac482
Keller, J G, Hymøller, K M, Thorsager, M E, Hansen, N Y, Erlandsen, J U, Tesauro, C, Simonsen, A K W, Andersen, A B, Vandsø Petersen, K, Holm, L L, Stougaard, M, Andresen, B S, Kristensen, P, Frøhlich, R & Knudsen, B R 2022, ' Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation ', Nucleic Acids Research, vol. 50, no. 11, pp. 6332-6342 . https://doi.org/10.1093/nar/gkac482

We have investigated the function of human topoisomerase 1 (TOP1) in regulation of G-quadruplex (G4) formation in the Pu27 region of the MYC P1 promoter. Pu27 is among the best characterized G4 forming sequences in the human genome and it is well kno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606b4feca49e6ce6db36ead898879b1b
https://vbn.aau.dk/da/publications/547d3b84-5a5b-4882-947d-67ad863246d1