Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Noriko Takegahara"'
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 2, Pp 264-272 (2024)
Abstract Osteoclasts are the principal cells that efficiently resorb bone. Numerous studies have attempted to reveal the molecular pathways leading to the differentiation and activation of osteoclasts to improve the treatment and prevention of osteop
Externí odkaz:
https://doaj.org/article/403cd99855314740bcc0d03e5d8c3815
Publikováno v:
Bone Research, Vol 11, Iss 1, Pp 1-13 (2023)
Abstract Osteoclasts are primary bone-resorbing cells, and receptor-activated NF-kB ligand (RANKL) stimulation is the key driver of osteoclast differentiation. During late-stage differentiation, osteoclasts become multinucleated and enlarged (so-call
Externí odkaz:
https://doaj.org/article/ae6a28ed9b254cf8b61b181479316b00
Publikováno v:
Cells, Vol 12, Iss 15, p 1967 (2023)
Protocadherin-7 (Pcdh7) is a member of the non-clustered protocadherin δ1 subgroup of the cadherin superfamily. Pcdh7 has been revealed to control osteoclast differentiation by regulating Rho-family small GTPases, RhoA and Rac1, through its intracel
Externí odkaz:
https://doaj.org/article/146f6c03a1c4485184e4ca0a207b02fd
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 13117 (2021)
Protocadherin-7 (Pcdh7) is a member of the non-clustered protocadherin δ1 subgroup of the cadherin superfamily. Although the cell-intrinsic role of Pcdh7 in osteoclast differentiation has been demonstrated, the molecular mechanisms of Pcdh7 regulati
Externí odkaz:
https://doaj.org/article/2dd15061a3ab47f2a85485000b55d930
Autor:
Hyunsoo Kim, Matthew C. Walsh, Noriko Takegahara, Sarah A. Middleton, Hong-In Shin, Junhyong Kim, Yongwon Choi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Excessive bone resorption by osteoclasts (OCs) can result in serious clinical outcomes, including bone loss that may weaken skeletal or periodontal strength. Proper bone homeostasis and skeletal strength are maintained by balancing OC functi
Externí odkaz:
https://doaj.org/article/570b4bebfc7a4da78d4458ebaf52f774
Autor:
Tetsuya Kimura, Shigeyuki Nada, Noriko Takegahara, Tatsusada Okuno, Satoshi Nojima, Sujin Kang, Daisuke Ito, Keiko Morimoto, Takashi Hosokawa, Yoshitomo Hayama, Yuichi Mitsui, Natsuki Sakurai, Hana Sarashina-Kida, Masayuki Nishide, Yohei Maeda, Hyota Takamatsu, Daisuke Okuzaki, Masaki Yamada, Masato Okada, Atsushi Kumanogoh
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
The role of nutrient-sensing pathways in regulation of innate immune response is unexplored. Here the authors show that IL-4 activates the amino-acid sensing pathway in macrophages and leads to polarization of anti-inflammatory M2 macrophages via the
Externí odkaz:
https://doaj.org/article/924eb32133c34310becad7e489a068dc
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2646 (2020)
Differentiation of osteoclasts, which are specialized multinucleated macrophages capable of bone resorption, is driven primarily by receptor activator of NF-κB ligand (RANKL). Additional signaling from cell surface receptors, such as cell adhesion m
Externí odkaz:
https://doaj.org/article/64e0c4a6a2f74f36b3200f288cc82d6f
Autor:
Tetsuya Kimura, Shigeyuki Nada, Noriko Takegahara, Tatsusada Okuno, Satoshi Nojima, Sujin Kang, Daisuke Ito, Keiko Morimoto, Takashi Hosokawa, Yoshitomo Hayama, Yuichi Mitsui, Natsuki Sakurai, Hana Sarashina-Kida, Masayuki Nishide, Yohei Maeda, Hyota Takamatsu, Daisuke Okuzaki, Masaki Yamada, Masato Okada, Atsushi Kumanogoh
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-2 (2017)
Nature Communications 7 Article number: 13130 (2016); Published 12 October 2016; Updated 27 February 2017 In this Article, there are errors in the labelling of the x axis in Fig. 5g,h that were introduced during the production process. The second lab
Externí odkaz:
https://doaj.org/article/7d64ba6be4ac4cd68928ac6e06c92cca
Autor:
Viola Maier, Christine Jolicoeur, Helen Rayburn, Noriko Takegahara, Atsushi Kumanogoh, Hitoshi Kikutani, Marc Tessier-Lavigne, Wolfgang Wurst, Roland H. Friedel
Publikováno v:
Mol Cell Neurosci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aafd927a40e5a595f809bcc9e739885
https://europepmc.org/articles/PMC10247391/
https://europepmc.org/articles/PMC10247391/
Publikováno v:
Bone
Since the receptor activator of nuclear factor-kappa B ligand (RANKL), its cognate receptor receptor activator of nuclear factor-kappa B (RANK), and the decoy receptor osteoprotegerin (OPG) were discovered, a number of studies have uncovered the cruc