Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Noriko Koizumi"'
Autor:
Tatsuya Nakagawa, Naoki Okumura, Masaya Ikegawa, Yumiko Toyama, Takashi Nirasawa, Frederic Mascarelli, Hanielle Vaitinadapoule, Ines Aouimeur, Zhiguo He, Philippe Gain, Gilles Thuret, Noriko Koizumi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Fuchs endothelial corneal dystrophy (FECD) is a slowly evolving, bilateral disease of the corneal endothelium, characterized by an abnormal accumulation of extracellular matrix (ECM) in the basement membrane (Descemet’s membrane, DM). This
Externí odkaz:
https://doaj.org/article/8c59418b36a042c893cb972500c94ff7
Autor:
Tatsuya Nakagawa, Yuichi Tokuda, Masakazu Nakano, Yuya Komori, Naoya Hanada, Theofilos Tourtas, Ursula Schlötzer-Schrehardt, Friedrich Kruse, Kei Tashiro, Noriko Koizumi, Naoki Okumura
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Fuchs endothelial corneal dystrophy (FECD) is the most common inherited corneal disease. Fibrillar focal excrescences called guttae and corneal edema due to corneal endothelial cell death result in progressive vision loss. Multiple genetic v
Externí odkaz:
https://doaj.org/article/31aea138aba940c484389fee5bc6da67
Autor:
Naoki Okumura, Takeru Nishikawa, Chiaki Imafuku, Yuki Matsuoka, Yuna Miyawaki, Shinichi Kadowaki, Makiko Nakahara, Yasushi Matsuoka, Noriko Koizumi
Publikováno v:
Bioengineering, Vol 11, Iss 1, p 71 (2024)
Corneal endothelial decompensation is treated by the corneal transplantation of donor corneas, but donor shortages and other problems associated with corneal transplantation have prompted investigations into tissue engineering therapies. For clinical
Externí odkaz:
https://doaj.org/article/7f3db3b13ca84dbf92e216715dcd8412
Autor:
Yasufumi Tomioka, Koji Kitazawa, Hideki Fukuoka, Morio Ueno, Noriko Koizumi, Chie Sotozono, Shigeru Kinoshita
Publikováno v:
American Journal of Ophthalmology Case Reports, Vol 30, Iss , Pp 101839- (2023)
Purpose: To report the safety, efficacy, and long-term outcome in a case of Fuchs endothelial corneal dystrophy (FECD) treated by Rho-associated protein kinase (ROCK)-inhibitor eye drops in combination with removal of degenerated corneal endothelial
Externí odkaz:
https://doaj.org/article/2c070629582049868a3d848b39ff53d5
Autor:
Naoki Okumura, Keisuke Hashimoto, Miu Kitahara, Hirokazu Okuda, Emi Ueda, Kyoko Watanabe, Makiko Nakahara, Takahiko Sato, Shigeru Kinoshita, Theofilos Tourtas, Ursula Schlötzer-Schrehardt, Friedrich Kruse, Noriko Koizumi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Fuchs endothelial corneal dystrophy (FECD) is a slowly progressive bilateral disease of corneal endothelium in which accumulation of extracellular matrix (ECM) and loss of corneal endothelial cells (CECs) are phenotypic features. The corneal
Externí odkaz:
https://doaj.org/article/2bcf614c5cd14afdb25ec7f9a4fe5f01
Autor:
Naresh Polisetti, Lydia Sorokin, Naoki Okumura, Noriko Koizumi, Shigeru Kinoshita, Friedrich E. Kruse, Ursula Schlötzer-Schrehardt
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Optimization of culture conditions for human limbal epithelial stem/progenitor cells (LEPC) that incorporate the in vivo cell-matrix interactions are essential to enhance LEPC ex vivo-expansion and transplantation efficiency. Here, we invest
Externí odkaz:
https://doaj.org/article/1507635635b5490a96657eab0f81eef8
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218431 (2019)
Transparency of the cornea is essential for vision and is maintained by the corneal endothelium. Consequently, corneal endothelial decompensation arising from irreversible damage to the corneal endothelium causes severe vision impairment. Until recen
Externí odkaz:
https://doaj.org/article/eb9ea7a8e73143a79269c879358e9375
Autor:
Naoki Okumura, Daiki Matsumoto, Yuya Fukui, Masataka Teramoto, Hirofumi Imai, Tetta Kurosawa, Tomoki Shimada, Friedrich Kruse, Ursula Schlötzer-Schrehardt, Shigeru Kinoshita, Noriko Koizumi
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191306 (2018)
Corneal transparency is maintained by the corneal endothelium through its pump and barrier function. Severe corneal endothelial damage results in dysregulation of water flow and eventually causes corneal haziness and deterioration of visual function.
Externí odkaz:
https://doaj.org/article/6019033f088a4667b41885d2eaf617dc
Publikováno v:
Stem Cells International, Vol 2017 (2017)
It is well known that myogenic regulatory factors encoded by the Myod1 family of genes have pivotal roles in myogenesis, with partially overlapping functions, as demonstrated for the mouse embryo. Myogenin-mutant mice, however, exhibit severe myogeni
Externí odkaz:
https://doaj.org/article/477317b0aff9441a9db36f2530e47418
Publikováno v:
Journal of Ophthalmology, Vol 2017 (2017)
ROCK (Rho kinase) signaling regulates a wide spectrum of fundamental cellular events and is involved in a variety of pathological conditions. It has therefore attracted research interest as a potential therapeutic target for combating various disease
Externí odkaz:
https://doaj.org/article/7a07b1481e8c46889a7517884d651f8b