Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Noriko Uchiyama"'
Autor:
Tyler Funnell, Shinya Tasaki, Arusha Oloumi, Shinsuke Araki, Esther Kong, Damian Yap, Yusuke Nakayama, Christopher S. Hughes, S.-W. Grace Cheng, Hirokazu Tozaki, Misa Iwatani, Satoshi Sasaki, Tomohiro Ohashi, Tohru Miyazaki, Nao Morishita, Daisuke Morishita, Mari Ogasawara-Shimizu, Momoko Ohori, Shoichi Nakao, Masatoshi Karashima, Masaya Sano, Aiko Murai, Toshiyuki Nomura, Noriko Uchiyama, Tomohiro Kawamoto, Ryujiro Hara, Osamu Nakanishi, Karey Shumansky, Jamie Rosner, Adrian Wan, Steven McKinney, Gregg B. Morin, Atsushi Nakanishi, Sohrab Shah, Hiroyoshi Toyoshiba, Samuel Aparicio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The phosphorylation of serine/arginine-rich proteins by CDC-like kinase is a central regulatory mechanism for RNA splicing reactions. Here, the authors synthesize a novel small molecule CLK inhibitor and map CLK-responsive alternative splicing events
Externí odkaz:
https://doaj.org/article/5aad2179e7e647afa20357dc81dea1bc
Autor:
Erik Kupperman, Keisuke Kuida, Johnny Yang, Lilly Zhang, Zhe Nie, Sheldon Cao, Takashi Ichikawa, Takashi Sato, Tomohiro Kawamoto, Maki Hasegawa, Noriko Uchiyama, Saomi Murai, Isao Kaieda, Hitoshi Miyashita, Kouki Hikami, Kohei Honda, Yuichi Hikichi
PDF file - 85K, Relationship between TP53 (A) or KRAS (B) gene status and TAK 960 concentration producing EC50 values. Each data point represents a mean concentration producing 50% efficacy (EC50) value for TAK 960 in an individual cell line.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037c5158dd41a6fa50297705386dad3a
https://doi.org/10.1158/1535-7163.22498093
https://doi.org/10.1158/1535-7163.22498093
Autor:
Erik Kupperman, Keisuke Kuida, Johnny Yang, Lilly Zhang, Zhe Nie, Sheldon Cao, Takashi Ichikawa, Takashi Sato, Tomohiro Kawamoto, Maki Hasegawa, Noriko Uchiyama, Saomi Murai, Isao Kaieda, Hitoshi Miyashita, Kouki Hikami, Kohei Honda, Yuichi Hikichi
PDF file - 144K, Comparison of dosing regimens.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674e354c643ecb3506f27cf3520f539f
https://doi.org/10.1158/1535-7163.22498090
https://doi.org/10.1158/1535-7163.22498090
Autor:
Erik Kupperman, Keisuke Kuida, Johnny Yang, Lilly Zhang, Zhe Nie, Sheldon Cao, Takashi Ichikawa, Takashi Sato, Tomohiro Kawamoto, Maki Hasegawa, Noriko Uchiyama, Saomi Murai, Isao Kaieda, Hitoshi Miyashita, Kouki Hikami, Kohei Honda, Yuichi Hikichi
PDF file - 61K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be286742458da7f5289a6faab7f0a56
https://doi.org/10.1158/1535-7163.22498081.v1
https://doi.org/10.1158/1535-7163.22498081.v1
Autor:
Erik Kupperman, Keisuke Kuida, Johnny Yang, Lilly Zhang, Zhe Nie, Sheldon Cao, Takashi Ichikawa, Takashi Sato, Tomohiro Kawamoto, Maki Hasegawa, Noriko Uchiyama, Saomi Murai, Isao Kaieda, Hitoshi Miyashita, Kouki Hikami, Kohei Honda, Yuichi Hikichi
Polo-like kinase 1 (PLK1) is a serine/threonine protein kinase involved in key processes during mitosis. Human PLK1 has been shown to be overexpressed in various human cancers, and elevated levels of PLK1 have been associated with poor prognosis, mak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0293f8b92cae4c943434996c1890ddc7
https://doi.org/10.1158/1535-7163.c.6535786
https://doi.org/10.1158/1535-7163.c.6535786
Autor:
Erik Kupperman, Keisuke Kuida, Johnny Yang, Lilly Zhang, Zhe Nie, Sheldon Cao, Takashi Ichikawa, Takashi Sato, Tomohiro Kawamoto, Maki Hasegawa, Noriko Uchiyama, Saomi Murai, Isao Kaieda, Hitoshi Miyashita, Kouki Hikami, Kohei Honda, Yuichi Hikichi
PDF file - 130K, Anti-tumor activity of TAK-960 in MV4-11luc disseminated leukemia model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cb82c738efd1b506e891eb7ac6552a
https://doi.org/10.1158/1535-7163.22498084
https://doi.org/10.1158/1535-7163.22498084
Autor:
Richard Tjhen, Noriko Uchiyama, Michiko Tawada, Yohei Kosugi, Satoshi Endo, Huikai Sun, Kei Masuda, Makoto Fushimi, Tatsuki Koike, Weston Lane
Publikováno v:
Journal of Medicinal Chemistry. 64:1103-1115
O-GlcNAcase (OGA) has received increasing attention as an attractive therapeutic target for tau-mediated neurodegenerative disorders; however, its role in these pathologies remains unclear. Therefore, potent chemical tools with favorable pharmacokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d202dd30fc9d83817cf7c025a625af2
https://doi.org/10.1021/acs.jmedchem.0c01712
https://doi.org/10.1021/acs.jmedchem.0c01712
Autor:
Masanori Okaniwa, Daisuke Morishita, Michael G. Klein, Yuta Tanaka, Bunnai Saito, Shigemitsu Matsumoto, Shinichi Imamura, Hiromichi Kimura, Geza Ambrus-Aikelin, Noriko Uchiyama, Osamu Kurasawa, Akihiro Yokota
Publikováno v:
ACS Medicinal Chemistry Letters
Deoxyhypusine synthase (DHPS) is the primary enzyme responsible for the hypusine modification and, thereby, activation of the eukaryotic translation initiation factor 5A (eIF5A), which is key in regulating the protein translation processes associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bd704a89e8cc67818ed1d96f73e5cb
https://doi.org/10.1021/acsmedchemlett.0c00331
https://doi.org/10.1021/acsmedchemlett.0c00331
Autor:
Masanori Okaniwa, Geza Ambrus-Aikelin, Shigemitsu Matsumoto, Yuta Tanaka, Akihiro Yokota, Koji Ono, Kazumasa Ogawa, Daisuke Morishita, Satoshi Kitazawa, Osamu Kurasawa, Michael G. Klein, Shinichi Imamura, Hiromichi Kimura, Noriko Uchiyama, Bunnai Saito
Publikováno v:
Journal of Medicinal Chemistry. 63:3215-3226
Deoxyhypusine synthase (DHPS) utilizes spermidine and NAD as cofactors to incorporate a hypusine modification into the eukaryotic translation initiation factor 5A (eIF5A). Hypusine is essential for eIF5A activation, which, in turn, plays a key role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e648ed2ccf973369eef613b4ca77329
https://doi.org/10.1021/acs.jmedchem.9b01979
https://doi.org/10.1021/acs.jmedchem.9b01979
Autor:
Toshiyuki Nomura, Hiroshi Sugimoto, Noriko Uchiyama, Akihiro Ohashi, Hideto Hara, Takashi Imada, Yukiko Yamamoto, Isaac Hoffman, Kenichi Iwai, Momoko Ohori, Misaki Homma, Osamu Kurasawa, Nobuo Cho, Tohru Miyazaki, Yuya Oguro, Kentaro Iwata, Robert J. Skene
Publikováno v:
Journal of Medicinal Chemistry. 63:1084-1104
In our pursuit of developing a novel, potent, and selective cell division cycle 7 (Cdc7) inhibitor, we optimized the previously reported thieno[3,2-d]pyrimidinone analogue I showing time-dependent Cdc7 kinase inhibition and slow dissociation kinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::302cc8787b4b0af51ff2d819e10565ac
https://doi.org/10.1021/acs.jmedchem.9b01427
https://doi.org/10.1021/acs.jmedchem.9b01427