Supplementary Materials and Methods, Supplementary Tables 1 and 2 and Supplementary Figures 1 through 5 from PTP1B Deficiency Enables the Ability of a High-Fat Diet to Drive the Invasive Character of PTEN-Deficient Prostate Cancers

Autor: Michel L. Tremblay, Marilène Paquet, Lloyd C. Trotman, Louis R. Bégin, Jody J. Haigh, Jacinthe Sirois, Eva Migon, Isabelle Aubry, Laurent Lessard, Valérie Vinette, Noriko Uetani, David P. Labbé

Supplementary Materials and Methods. Table S1: List of the different oligonucleotides used for mouse genotyping. Table S2: Phenotypic evaluation of prostate-specific PTP1B-overexpressing mice. Figure S1: Ptpn1 status does not alter the transition to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d4187cf43d71fb541eb857d7e17dfa
https://doi.org/10.1158/0008-5472.22409255

Data from PTP1B Deficiency Enables the Ability of a High-Fat Diet to Drive the Invasive Character of PTEN-Deficient Prostate Cancers

Autor: Michel L. Tremblay, Marilène Paquet, Lloyd C. Trotman, Louis R. Bégin, Jody J. Haigh, Jacinthe Sirois, Eva Migon, Isabelle Aubry, Laurent Lessard, Valérie Vinette, Noriko Uetani, David P. Labbé

Diet affects the risk and progression of prostate cancer, but the interplay between diet and genetic alterations in this disease is not understood. Here we present genetic evidence in the mouse showing that prostate cancer progression driven by loss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7784c025532018fc20affc6bfe1b7047
https://doi.org/10.1158/0008-5472.c.6507737.v1

Protein tyrosine phosphatome metabolic screen identifies TC‐PTP as a positive regulator of cancer cell bioenergetics and mitochondrial dynamics

Autor: Michel L. Tremblay, Serge Hardy, Noriko Uetani, Isabelle Aubry, Valerie Vinette, Hayley Insull

Publikováno v: The FASEB Journal. 35

Metabolic reprogramming occurs in cancer cells and is regulated partly by the opposing actions of tyrosine kinases and tyrosine phosphatases. Several members of the protein tyrosine phosphatase (PTP) superfamily have been linked to cancer as either p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b0cdbb4ca83292a8fce271ca0eda94
https://doi.org/10.1096/fj.202100207r

ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs

Autor: Luis Alfonso Martínez-Cruz, Femke Latta, Serge Hardy, Jonathan Boulais, Joost G. J. Hoenderop, Gijs A C Franken, Jean-François Côté, Chao Ma, Antonio Díaz Quintana, Yevgen Zolotarov, Michel L. Tremblay, Marie-Pier Thibault, Jeroen H. F. de Baaij, Elie Kostantin, Noriko Uetani, Irene González-Recio, Irene Díaz-Moreno

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Cellular and Molecular Life Sciences, 78, 13, pp. 5427-5445
Cellular and Molecular Life Sciences, 78, 5427-5445
Cellular and Molecular Life Sciences

Cyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg2+) homeostasis. Using various biochemical approaches, we have identified members of the CNNM family as direct interacting partners of ADP-ribosylation factor-like GTPase 15 (ARL15),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc43bc3701cb4f71ed4f97287b86cbaa
https://doi.org/10.1101/2020.09.09.289835

Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse.

Autor: Syed-Wajahat Hassan, Karen M Doody, Serge Hardy, Noriko Uetani, Denis Cournoyer, Michel L Tremblay

Publikováno v: PLoS ONE, Vol 5, Iss 1, p e8868 (2010)

T cell protein tyrosine phosphatase (TC-PTP/PTPN2) is an enzyme that is essential for the proper functioning of the immune system and that participates in the control of cell proliferation, and inflammation. We previously observed that TC-PTP(-/-) mi

Externí odkaz: https://doaj.org/article/df69c264e6f24e7da18d7cfc14b32b6a