Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Noriko, Masubuchi"'
Autor:
Tomonori Sugita, Katsushi Amano, Masanori Nakano, Noriko Masubuchi, Masahiro Sugihara, Tomokazu Matsuura
Publikováno v:
Gastroenterology Research and Practice, Vol 2015 (2015)
Objectives. We determined the serum bile acid (BA) composition in patients with liver diseases and healthy volunteers to investigate the relationship between the etiologies of liver disease and BA metabolism. Material and Methods. Sera from 150 patie
Externí odkaz:
https://doaj.org/article/97256ef983154b01800b45602e231bc3
Publikováno v:
Chemico-Biological Interactions. 255:74-82
Promising biomarkers were identified in adult male Crl:CD (SD) rats for the screening of new chemical entities for their potential to cause liver injury. We examined the serum biochemistry, liver histopathology, and bile acid profiles by LC-MS/MS, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ba7709eaad99e65eddfe00e2473f11
https://doi.org/10.1016/j.cbi.2015.09.012
https://doi.org/10.1016/j.cbi.2015.09.012
Autor:
Takahiro Nagayama, Takahide Nishi, Chie Sugita, Kazuhiko Tamaki, Yumi Matsui, Teppei Fujimoto, Kenichi Manabe, Ogawa Yasuyuki, Katsuyoshi Chiba, Noriko Masubuchi, Mizuki Takahashi, Shojiro Miyazaki, Makoto Mizuno, Yuji Nakamura
Publikováno v:
ACS Medicinal Chemistry Letters. 3:754-758
A novel orally bioavailable renin inhibitor, DS-8108b (5), showing potent renin inhibitory activity and excellent in vivo efficacy is described. We report herein the synthesis and pharmacological effects of 5 including renin inhibitory activity in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4768bdbd470e9703d3327b13364269d1
https://doi.org/10.1021/ml300168e
https://doi.org/10.1021/ml300168e
Autor:
Ryotaku Inoue, Reina Kaneko, Tsuyoshi Nakamura, Hiroshi Yuita, Tetsufumi Koga, Eiko Namba, Hatsumi Nasu, Takahide Nishi, Takashi Kagari, Yukiko Sekiguchi, Yumi Kawase, Kazuhiko Tamaki, Shintaro Nakayama, Keiko Oguchi-Oshima, Takaichi Shimozato, Noriko Masubuchi, Yumiko Mizuno, Masayoshi Asano, Takahiro Yamaguchi, Wataru Tomisato, Futoshi Nara, Hiromi Doi-Komuro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3083-3088
We have previously disclosed 1,2,4-oxadiazole derivative 3 as a potent S1P3-sparing S1P1 agonist. Although compound 3 exhibits potent and manageable immunosuppressive efficacy in various in vivo models, recent studies have revealed that its 1,2,4-oxa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dee7d6079550f2c98197e1e96700deda
https://doi.org/10.1016/j.bmcl.2012.03.067
https://doi.org/10.1016/j.bmcl.2012.03.067
Autor:
Takashi Izumi, Noriko Okudaira, Yoshiyuki Yabe, Takanori Aoki, Nobuyuki Murayama, Atsushi Kurihara, Noriko Masubuchi, Masataka Oitate, Tsuyoshi Karibe, Takashi Ito
Publikováno v:
Drug Metabolism and Pharmacokinetics. 26:423-430
Interspecies allometric scaling is a useful tool for calculating human pharmacokinetic (PK) parameters from data in animals. In this study, in order to determine the scaling exponent in a simple allometric equation that can predict human clearance (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3996ca41cec8cba7cf9145a549efc866
https://doi.org/10.2133/dmpk.dmpk-11-rg-011
https://doi.org/10.2133/dmpk.dmpk-11-rg-011
Autor:
Sunao Manabe, Takayoshi Nishiya, Kazuhiko Mori, Chiharu Hattori, Kiyonori Kai, Hiroko Kataoka, Noriko Masubuchi, Toshimasa Jindo
Publikováno v:
Toxicology and Applied Pharmacology. 232:280-291
To investigate the hepatotoxic potential of tienilic acid in vivo , we administered a single oral dose of tienilic acid to Sprague–Dawley rats and performed general clinicopathological examinations and hepatic gene expression analysis using Affymet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b52c2cab9c15203160c998c8d1156df
https://doi.org/10.1016/j.taap.2008.06.024
https://doi.org/10.1016/j.taap.2008.06.024
Autor:
Tomonori Sugita, Masahiro Sugihara, Noriko Masubuchi, Tomokazu Matsuura, Katsushi Amano, Masanori Nakano
Publikováno v:
Chemico-biological interactions. 255
Clinicians sometimes encounter difficulty in choosing a therapeutic strategy due to the uncertainty regarding the type of liver injury. In particular, cholestasis is difficult to diagnose by conventional markers at an early stage of disease. The aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ebca63b3c4acbc89013913851eac9f
https://pubmed.ncbi.nlm.nih.gov/26325587
https://pubmed.ncbi.nlm.nih.gov/26325587
Autor:
Katsushi Amano, Tomokazu Matsuura, Masanori Nakano, Tomonori Sugita, Masahiro Sugihara, Noriko Masubuchi
Publikováno v:
Gastroenterology Research and Practice
Gastroenterology Research and Practice, Vol 2015 (2015)
Gastroenterology Research and Practice, Vol 2015 (2015)
Objectives. We determined the serum bile acid (BA) composition in patients with liver diseases and healthy volunteers to investigate the relationship between the etiologies of liver disease and BA metabolism.Material and Methods. Sera from 150 patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391cbb5d7d1e94424914eff13908aa0a
https://pubmed.ncbi.nlm.nih.gov/25821461
https://pubmed.ncbi.nlm.nih.gov/25821461
Publikováno v:
Chemico-Biological Interactions. 114:1-13
Primary human hepatocytes contain a full complement of human drug-metabolizing enzymes and therefore represent a relevant experimental system for the evaluation of pharmacokinetic drug-drug interaction potential in human. In this study, the cytochrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0ad0452a58769f429cf6954c49fb80
https://doi.org/10.1016/s0009-2797(98)00031-3
https://doi.org/10.1016/s0009-2797(98)00031-3
Publikováno v:
Biochemical Pharmacology. 54:1225-1231
The effects of proton pump inhibitors on thyroid hormone metabolism in rats were examined. Pantoprazole, omeprazole, and lansoprazole were administered repeatedly to female SD rats at doses of 5, 50, and 300 mg/kg/day for 1 week, and changes in UDP-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abeb7fa19ae1cc1e77293686153b9efc
https://doi.org/10.1016/s0006-2952(97)00327-4
https://doi.org/10.1016/s0006-2952(97)00327-4