Opioid drug seeking after early-life adversity: a role for delta opioid receptors

Autor: Sophia C. Levis, Matthew T. Birnie, Yiyan Xie, Noriko Kamei, Puja V. Kulkarni, Johanna S. Montesinos, Christina R. Perrone, Catherine M. Cahill, Tallie Z. Baram, Stephen V. Mahler

Publikováno v: Addiction Neuroscience, Vol 13, Iss , Pp 100175- (2024)

Opioid use disorder (OUD) is associated with a history of early-life adversity (ELA), an association that is particularly strong in women. In a rodent model, we previously found that ELA enhances risk for opioid addiction selectively in females, but

Externí odkaz: https://doaj.org/article/8d64dd9956d94e94af54816248959924

Single-Cell Transcriptional Changes in Hypothalamic Corticotropin-Releasing Factor–Expressing Neurons After Early-Life Adversity Inform Enduring Alterations in Vulnerabilities to Stress

Autor: Annabel K. Short, Christina W. Thai, Yuncai Chen, Noriko Kamei, Aidan L. Pham, Matthew T. Birnie, Jessica L. Bolton, Ali Mortazavi, Tallie Z. Baram

Publikováno v: Biological Psychiatry Global Open Science, Vol 3, Iss 1, Pp 99-109 (2023)

Background: Mental health and vulnerabilities to neuropsychiatric disorders involve the interplay of genes and environment, particularly during sensitive developmental periods. Early-life adversity (ELA) and stress promote vulnerabilities to stress-r

Externí odkaz: https://doaj.org/article/36084c5dad3d4921b7406a533444ff1b

Unexpected Transcriptional Programs Contribute to Hippocampal Memory Deficits and Neuronal Stunting after Early-Life Adversity

Autor: Jessica L. Bolton, Anton Schulmann, Megan M. Garcia-Curran, Limor Regev, Yuncai Chen, Noriko Kamei, Manlin Shao, Akanksha Singh-Taylor, Shan Jiang, Yoav Noam, Jenny Molet, Ali Mortazavi, Tallie Z. Baram

Publikováno v: Cell Reports, Vol 33, Iss 11, Pp 108511- (2020)

Summary: Early-life adversity (ELA) is associated with lifelong memory deficits, yet the responsible mechanisms remain unclear. We impose ELA by rearing rat pups in simulated poverty, assess hippocampal memory, and probe changes in gene expression, t

Externí odkaz: https://doaj.org/article/4bf6ad0ca44047a889a6263685153df9

CD133-enriched Xeno-Free human embryonic-derived neural stem cells expand rapidly in culture and do not form teratomas in immunodeficient mice

Autor: Daniel L. Haus, Hal X. Nguyen, Eric M. Gold, Noriko Kamei, Harvey Perez, Harry D. Moore, Aileen J. Anderson, Brian J. Cummings

Publikováno v: Stem Cell Research, Vol 13, Iss 2, Pp 214-226 (2014)

Common methods for the generation of human embryonic-derived neural stem cells (hNSCs) result in cells with potentially compromised safety profiles due to maintenance of cells in conditions containing non-human proteins (e.g. in bovine serum or on mo

Externí odkaz: https://doaj.org/article/0afe92b0566e46269311a9bc172a542f

Intra-individual methylomics detects the impact of early-life adversity

Autor: Shan Jiang, Jessica L. Bolton, Noriko Kamei, Hal S. Stern, Ali Mortazavi, Tallie Z. Baram, Xinyi Ma

Publikováno v: Life Science Alliance
Jiang, Shan; Kamei, Noriko; Bolton, Jessica L; Ma, Xinyi; Stern, Hal S; Baram, Tallie Z; et al.(2019). Intra-individual methylomics detects the impact of early-life adversity.. Life science alliance, 2(2), e201800204-e201800204. doi: 10.26508/lsa.201800204. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9mg4g7b2

This study shows that methylation profile changes across time in the same individual distinguish a stressful experience from typical infancy, providing a potential predictive marker of vulnerability to disease.
Genetic and environmental factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae18373ec5bbfe9132f7f15e735aa20
https://pubmed.ncbi.nlm.nih.gov/30936186