Výsledky vyhledávání - "Norihito Muranaka"

Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with an endemic human CoV

Publikováno v: bioRxiv : the preprint server for biology.

A high-resolution understanding of the antibody response to SARS-CoV-2 is important for the design of effective diagnostics, vaccines and therapeutics. However, SARS-CoV-2 antibody epitopes remain largely uncharacterized, and it is unknown whether an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8133390e81a05f8024c20170b407dce6
https://pubmed.ncbi.nlm.nih.gov/33495758

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Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses

Publikováno v: Cell Reports Medicine
bioRxiv
article-version (status) pre
article-version (number) 1

The SARS-CoV-2 proteome shares regions of conservation with endemic human coronaviruses (CoVs), but it remains unknown to what extent these may be cross-recognized by the antibody response. Here, we study cross-reactivity using a highly multiplexed p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd463148630856d2ef5ab47299676987
http://europepmc.org/articles/PMC7816965

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High-Throughput Multiplexed Peptide-Centric Profiling Illustrates Both Substrate Cleavage Redundancy and Specificity in the MMP Family

Autor: Alex Y. Strongin, Igor A. Kozlov, Norihito Muranaka, Sonu Kumar, Muskan Kukreja, Piotr Cieplak, David A. Routenberg, Andrei V. Chernov, Jeffrey W. Smith, Sergey A. Shiryaev, Albert G. Remacle

Publikováno v: Chemistry & Biology. 22:1122-1133

SummaryMatrix metalloproteinases (MMPs) play incompletely understood roles in health and disease. Knowing the MMP cleavage preferences is essential for a better understanding of the MMP functions and design of selective inhibitors. To elucidate the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83797b4eabd047b35aa5c594a382956
https://doi.org/10.1016/j.chembiol.2015.07.008

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Substrate Cleavage Profiling Suggests a Distinct Function of Bacteroides fragilis Metalloproteinases (Fragilysin and Metalloproteinase II) at the Microbiome-Inflammation-Cancer Interface

Autor: Norihito Muranaka, Andrei V. Chernov, Albert G. Remacle, Corey M. Dambacher, Muskan Kukreja, Petr Čapek, Khatereh Motamedchaboki, Piotr Cieplak, Igor A. Kozlov, Vladislav S. Golubkov, Manuel Perucho, Alex Y. Strongin, Sergey A. Shiryaev

Publikováno v: Journal of Biological Chemistry. 288:34956-34967

Enterotoxigenic anaerobic Bacteroides fragilis is a significant source of inflammatory diarrheal disease and a risk factor for colorectal cancer. Two distinct metalloproteinase types (the homologous 1, 2, and 3 isoforms of fragilysin (FRA1, FRA2, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635cd6d997f35e5ffa0af735146cf144
https://doi.org/10.1074/jbc.m113.516153

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Biosynthesis of proteins containing modified lysines and fluorescent labels using non-natural amino acid mutagenesis

Autor: Kaori Shiraga, Takahiro Hohsaka, Kazushi Horiike, Yasunori Tokuda, Ryoji Abe, Takayoshi Watanabe, Norihito Muranaka

Publikováno v: Journal of Bioscience and Bioengineering. 111:402-407

The preparation of posttranslationally modified proteins is required to investigate the function and structure of modified proteins. However, homogeneously modified proteins are not easily isolated from natural sources or prepared using modification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e6c719b976a544ac898bdbb7fe61fa
https://doi.org/10.1016/j.jbiosc.2010.12.012

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Incorporation of Fluorescent-Labeled Non-α-Amino Carboxylic Acids into the N-Terminus of Proteins in Response to Amber Initiation Codon

Autor: Norihito Muranaka, Ryoji Abe, Takahiro Hohsaka, Masanori Miura

Publikováno v: Bulletin of the Chemical Society of Japan. 83:546-553

Incorporation of non-natural amino acid derivatives containing fluorescent groups into proteins is a useful method for protein analyses. Here, we investigated the incorporation of fluorescent-label...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a4508ecbaae79d3486c912bb45b40a0
https://doi.org/10.1246/bcsj.20090320

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Mechanism-Guided Library Design and Dual Genetic Selection of Synthetic OFF Riboswitches

Autor: Koichi Abe, Yohei Yokobayashi, Norihito Muranaka

Publikováno v: ChemBioChem. 10:2375-2381

After the recent discovery of bacterial riboswitches, synthetic riboswitches have been engineered by using natural and artificial RNA aptamers. In contrast to natural riboswitches, the majority of synthetic riboswitches in bacteria reported to date a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1fed088c5dc554bf6640d629bdbe795
https://doi.org/10.1002/cbic.200900313

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Efficient Design Strategy for Whole-Cell and Cell-Free Biosensors based on Engineered Riboswitches

Autor: Norihito Muranaka, Yohei Yokobayashi, Vandana Sharma, Yoko Nomura

Publikováno v: Analytical Letters. 42:108-122

We have applied dual genetic selection to design a bacterial riboswitch with improved sensitivity by employing a high-affinity heterologous thiamine pyrophosphate (TPP) aptamer and modified selection conditions in Escherichia coli. The cells transfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8fb3de3ddbd53e486e44044a4e0d0e4
https://doi.org/10.1080/00032710802568556

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N-Terminal Specific Fluorescence Labeling of Proteins through Incorporation of Fluorescent Hydroxy Acid and Subsequent Ester Cleavage

Autor: Takayoshi Watanabe, Takahiro Hohsaka, Ryoji Abe, Yoichi Miyata, Norihito Muranaka

Publikováno v: ChemBioChem. 9:1235-1242

We have developed a novel method to attach a fluorescent label at the N terminus of proteins through a four-base codon-mediated incorporation of a fluorescent hydroxy acid and subsequent cleavage of the ester bond in a cell-free translation system. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b124f52d12177f860466e38a8ecad02d
https://doi.org/10.1002/cbic.200700578

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Four-base codon-mediated saturation mutagenesis in a cell-free translation system

Autor: Takayoshi Watanabe, Norihito Muranaka, Takahiro Hohsaka

Publikováno v: Journal of Bioscience and Bioengineering. 105:211-215

Saturation mutagenesis is a useful technique for the structural and functional analyses of proteins and for protein engineering. However, the extensive mutagenesis of genes and expression of mutated proteins are tedious and time-consuming. We have de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0009b5f841d145a430e63c43b5040056
https://doi.org/10.1263/jbb.105.211

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