Výsledky vyhledávání - "Norihito Arichi"

Gold(I)‐Catalyzed Benzylic C(sp 3 )−H Functionalizations: Divergent Synthesis of Indole[ a ]‐ and [ b ]‐Fused Polycycles**

Autor: Luca C. Greiner, Norihito Arichi, Shinsuke Inuki, Hiroaki Ohno

Publikováno v: Angewandte Chemie International Edition. 62

Phenyl azides substituted by an (alkylphenyl)ethynyl group facilitate benzylic sp3 (C-H) functionalization in the presence of a JohnPhosAu catalyst, resulting in indole-fused tetra- and pentacycles via divergent N- or C-cyclization. The chemoselectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ceaff62e53365210a5182e468034356
https://doi.org/10.1002/anie.202213653

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Identification of Novel MR1 Ligands Derived from Herbal Medicines by MR1-Presentation Reporter Screening and Their Structure-Activity Relationship

Autor: Takuro Matsuoka, Akira Hattori, Shinya Oishi, Norihito Arichi, Hideaki Kakeya, Sho Yamasaki, Hiroaki Ohno, Shinsuke Inuki

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are modulated by ligands presented on MHC class I-related proteins (MR1). These cells have attracted attention as potential drug targets because of their involvement in the init

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4b725fe0932f13fab9ae97c590d72ff
https://doi.org/10.26434/chemrxiv-2022-jfddl

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Gold(I)-Catalyzed Benzylic C(sp3)-H Functionalizations: Product Bifurcation towards Indole[a]- and [b]-Fused Polycycles

Autor: Luca Greiner, Norihito Arichi, Shinsuke Inuki, Hiroaki Ohno

Phenylazides substituted by an (alkylphenyl)ethynyl group facilitate divergent benzylic sp3(C-H) functionalization in the presence of a JohnPhosAu catalyst, via N- or C-cyclization, resulting in indole-fused tetra- and pentacycles. The chemoselectivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea531e9ae867c65fe3e28b5518ed2006
https://doi.org/10.26434/chemrxiv-2022-tqg48

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Archaeal glycerolipids are recognized by C-type lectin receptor Mincle

Autor: Shiori Oka, Miyuki Watanabe, Emi Ito, Ami Takeyama, Takuro Matsuoka, Norihito Arichi, Hiroaki Ohno, Sho Yamasaki, Shinsuke Inuki

Recently, various metabolites derived from host microbes have been reported to modulate the immune system, with potential involvement in health or diseases. Archaea, prokaryotic organisms, are present in the human body, but their connection with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f372ad310b58f228c86d4bbdfcd1fda4
https://doi.org/10.26434/chemrxiv-2022-zb85t

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Construction of Tricyclic Nitrogen Heterocycles by a Gold(I)-Catalyzed Cascade Cyclization of Allenynes and Application to Polycyclic π-Electron Systems

Autor: Aiko Fukazawa, Hiroaki Ohno, Norihito Arichi, Shinsuke Inuki, Takaya Ikeuchi, Hiroki Komatsu, Kosuke Yasui, Hitomi Tsuno, Shinya Oishi

Publikováno v: Angewandte Chemie (International ed. in English). 60(52)

A novel approach to the direct construction of tricyclic nitrogen heterocycles based on gold-catalyzed cascade cyclization of aminoallenynes is described. The expected biscyclization reaction of hydroxyisobutyryl-protected aminoallenynes was efficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba53ac7299f3df92f40e9cb2d145248
https://pubmed.ncbi.nlm.nih.gov/34590766

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Access to Indole‐Fused Benzannulated Medium‐Sized Rings through a Gold(I)‐Catalyzed Cascade Cyclization of Azido‐Alkynes

Autor: A. Stephen K. Hashmi, Rikito Suzuki, Norihito Arichi, Shinya Oishi, Tomohiro Iwai, Hiroaki Ohno, Shinsuke Inuki, Luca C. Greiner, Masaya Sawamura

Publikováno v: Chemistry – A European Journal. 27:12921-12921

Because benzannulated and indole-fused medium-sized rings are found in many bioactive compounds, combining these fragments might lead to unexplored areas of biologically relevant and uncovered chemical space. Herein is shown that α-imino gold carben

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd6576fca6db99fa03a193018cd0ff9
https://doi.org/10.1002/chem.202102558

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Synthesis and biological evaluation of steroidal derivatives bearing a small ring as vitamin D receptor agonists

Autor: Duy H. Hua, Ken-ichi Yamada, Kiyosei Takasu, Michiyasu Ishizawa, Yousuke Yamaoka, Shinichi Fujiwara, Makoto Makishima, Norihito Arichi

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 27:3408-3411

A novel series of 3-ketolithocholic acid derivatives as well as estrone derivatives bearing a small ring for the conformational fixation of the side chain were synthesized by using a catalytic [2+2] cycloaddition and a ring-contraction rearrangement.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c294b7ae9f560c6c7868d95a54bbf610
https://doi.org/10.1016/j.bmcl.2017.05.089

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An Arylative Ring Expansion Cascade of Fused Cyclobutenes via Short-Lived Intermediates with Planar Chirality

Autor: Kiyosei Takasu, Yousuke Yamaoka, Norihito Arichi, Ken-ichi Yamada

Publikováno v: Journal of the American Chemical Society. 137:9579-9582

An arylative ring expansion cascade has been developed for the synthesis of medium-sized carbocycles from fused cyclobutenes. This reaction proceeds through a short-lived cis,trans-cycloalkadiene intermediate that is formed by thermal 4π electrocycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1862d234bf464a7b9d31e5225730f55a
https://doi.org/10.1021/jacs.5b06576

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