Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Norihiro Ikemoto"'
Autor:
Yuri Natori, Yoshiaki Kinase, Norihiro Ikemoto, Fabio Spaziani, Tsutomu Kojima, Hitomi Kakuta, Junko Fujita, Kazuyuki Someya, Katsuyoshi Tatenuma, Toshiyo Yabuta, Hiroki Takakuwa, Koichi Otsuki
Publikováno v:
C, Vol 7, Iss 4, p 86 (2021)
An iodine-doped activated carbon (named IodAC) was developed by adsorbing molecular iodine (I2) on commercially available activated carbon (AC). Iodine was selected with the purpose to add its well-known antibacterial and antiviral properties to the
Externí odkaz:
https://doaj.org/article/c328d50f60fd4dd79626ed117559f410
Autor:
Shunya Nakasone, Masahiro Tanaka, Yuji Ishizu, Norihiro Ikemoto, Masahide Furukawa, Yoshitaka Shiroma, Naofumi Akata
Publikováno v:
Japanese Journal of Health Physics. 53:65-71
Autor:
Yuri Natori, Katsuyoshi Tatenuma, Kazuo Yonehara, Masanori Hara, Tomohiko Kawakami, Norihiro Ikemoto
Publikováno v:
Fusion Engineering and Design. 158:111701
Molecular sieves (MSs) are a potentially useful means of hydrogen isotope recovery as well as the temporary storage and supply of such isotopes. In this study, the hydrogen adsorption isotherms for various MS samples were acquired after applying diff
Autor:
Andrew W. Gibson, Fouzia Machrouhi, Doug E. Frantz, Michael H. Kress, Cameron J. Cowden, Norihiro Ikemoto, Todd D. Nelson, Anthony Alorati, Brian C. Bishop, Karsten Menzel, Matthew S. Bodenstein
Publikováno v:
Organic Process Research & Development. 13:519-524
As part of Merck’s continued research effort on inflammation and pain, a safe synthesis of an orally bioavailable and CNS penetrant bradykinin 1 antagonist was developed and demonstrated on kilogram scale. The key step included a novel regioselecti
Autor:
Norihiro Ikemoto, Ross A. Miller, Jinchu Liu, Benjamin Marcune, Joseph Laquidara, Ralph P. Volante, Joseph D. Armstrong, Petrillo Daniel E, Fred J. Fleitz, Joseph F. Leone, Sandor Karady
Publikováno v:
Tetrahedron Letters. 46:1867-1871
Two syntheses of the title compound 1 were developed based on different approaches for installing the oxazole ring moiety. Formation and dehydration of ketoamide was initially used and scaled up to afford 1 on several kilogram scale, then oxazolyl an
Autor:
Pete Yehl, Robert B. Waters, Firoz D. Antia, Fred J. Fleitz, Joseph D. Armstrong, Christopher J. Welch, David J. Mathre, Norihiro Ikemoto
Publikováno v:
Organic Process Research & Development. 8:186-191
Chromatography plays a vital role in supporting preclinical pharmaceutical development, whether in providing assays for purity determinations, preparative separation of small amounts of intermediates for route selection studies, or purification of bu
Autor:
Jinchu Liu, Norihiro Ikemoto, Joseph D. Armstrong, Naijun Wu, Ralph P. Volante, Robert A. Reamer, Dan Petrillo, Fred J. Fleitz, Peter M. Yehl, Ronald H. Szumigala, Donald R. Gauthier
Publikováno v:
Tetrahedron: Asymmetry. 14:3557-3567
An efficient stereoselective preparation of HIV protease inhibitor (+)-1 was synthesized on multi-kilogram scale in 16 steps without the use of chromatography. The key steps include the diastereoselective alkylation of acetal 3, a diastereoselective
Publikováno v:
Tetrahedron. 59:1317-1325
A β3 adrenergic receptor agonist was prepared on a multi-kilogram scale in high yield and purity via a convergent synthesis. A key intermediate in this synthesis was an arylthiazolylbenzenesulfonyl chloride. The triaryl segment of this sulfonyl chlo
Autor:
Randolph Greasham, Norihiro Ikemoto, Kodzo Gbewonyo, Christine Chirdo, Barry C. Buckland, Carrie Ann Maxwell, Michel Chartrain, Vanessa Sandford, Jerelyn Osoria, Colleen S. Taylor, Sarah Stahl
Publikováno v:
Journal of Bioscience and Bioengineering. 90:321-327
An attractive method for producing cis-1,2-dihydroxy-3-methylcyclohexa-3,5-diene (toluene cis glycol) was developed employing a cis dihydrodiol dehydrogenase "deficient" strain of Rhodococcus (MA 7249). The toluene cis glycol produced was found to ha
Asymmetric direduction of 1,2-indanedione to cis (1S,2R) indanediol by Trichosporon cutaneum MY 1506
Publikováno v:
Journal of Bioscience and Bioengineering. 88:495-499
Cis (1 S ,2 R ) indanediol is a potential precursor to (−)- cis (1 S ,2 R )-1-aminoindan-2-ol, a key chiral synthon for a leading HIV protease inhibitor, Crixivan® (Indinavir). A potential route to the biosynthesis of this important precursor, the