Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Norihiko Furuya"'
Autor:
Shinji Saiki, Taku Hatano, Motoki Fujimaki, Kei-Ichi Ishikawa, Akio Mori, Yutaka Oji, Ayami Okuzumi, Takeshi Fukuhara, Takahiro Koinuma, Yoko Imamichi, Miho Nagumo, Norihiko Furuya, Shuko Nojiri, Taku Amo, Kazuo Yamashiro, Nobutaka Hattori
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Increasing evidence shows that metabolic abnormalities in body fluids are distinguishing features of the pathophysiology of Parkinson’s disease. However, a non-invasive approach has not been established in the earliest or pre-symptomatic p
Externí odkaz:
https://doaj.org/article/39cf9e83253748d8b72eb80e81610158
Autor:
Kei-Ichi Ishikawa, Shinji Saiki, Norihiko Furuya, Daisuke Yamada, Yoko Imamichi, Yuanzhe Li, Sumihiro Kawajiri, Hironori Sasaki, Masato Koike, Yoshio Tsuboi, Nobutaka Hattori
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94645 (2014)
Mutations in p150glued cause hereditary motor neuropathy with vocal cord paralysis (HMN7B) and Perry syndrome (PS). Here we show that both overexpression of p150glued mutants and knockdown of endogenous p150glued induce apoptosis. Overexpression of a
Externí odkaz:
https://doaj.org/article/3d63ff5e61b74cfe9c196bdc891bdec4
Autor:
Yu Takahashi, Akihiro Shinoda, Norihiko Furuya, Eri Harada, Naoto Arimura, Ikuyo Ichi, Yoko Fujiwara, Jun Inoue, Ryuichiro Sato
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64605 (2013)
Sterol regulatory element-binding protein-1 (SREBP-1) has been thought to be a critical factor that assists adipogenesis. During adipogenesis SREBP-1 stimulates lipogenic gene expression, and peroxisome proliferator-activated receptor γ (PPARγ) enh
Externí odkaz:
https://doaj.org/article/b7f03d56cf454dc59cd10377c7b4df8e
Autor:
Yukiko Sasazawa, Sanae Souma, Norihiko Furuya, Yoshiki Miura, Saiko Kazuno, Soichiro Kakuta, Ayami Suzuki, Ryota Hashimoto, Hiroko Hirawake‐Mogi, Yuki Date, Masaya Imoto, Takashi Ueno, Tetsushi Kataura, Viktor I Korolchuk, Taiji Tsunemi, Nobutaka Hattori, Shinji Saiki
Publikováno v:
The EMBO Journal. 41
Retrograde transport of lysosomes is recognised as a critical autophagy regulator. Here, we found that acrolein, an aldehyde that is significantly elevated in Parkinson's disease patient serum, enhances autophagy by promoting lysosomal clustering aro
Autor:
Yoko Imamichi, Yoshio Tsuboi, Shinji Saiki, Norihiko Furuya, Kei-Ichi Ishikawa, Nobutaka Hattori
Publikováno v:
Neuroscience Letters. 690:181-187
Dynein-dynactin has an indispensable role in autophagy and p150glued is the largest component of the dynactin complex. Here, we characterized the effects of knockdown (KD) of endogenous p150glued and of the pathogenic mutation of p150glued found in a
Autor:
Shuko Nojiri, Takeshi Fukuhara, Kei-Ichi Ishikawa, Yoko Imamichi, Norihiko Furuya, Shinji Saiki, Yutaka Oji, Akio Mori, Taku Hatano, Takahiro Koinuma, Nobutaka Hattori, Taku Amo, Ayami Okuzumi, Kazuo Yamashiro, Miho Nagumo, Motoki Fujimaki
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
Increasing evidence shows that metabolic abnormalities in body fluids are distinguishing features of the pathophysiology of Parkinson’s disease. However, a non-invasive approach has not been established in the earliest or pre-symptomatic phases. He
Autor:
Shinji Saiki, Norihiko Furuya, Wado Akamatsu, Yukiko Sasazawa, Yoko Imamichi, Kengo Miyamoto, Motoki Fujimaki, Sanae Souma, Nobutaka Hattori, Akihiro Yamaguchi, Kazuoki Hirano, Hideyuki Saya, Kei-Ichi Ishikawa, Daisuke Yamada
Publikováno v:
Biochemical and biophysical research communications. 518(1)
Introduction Chemical intervention of autophagy has been investigated in clinical trials for various age-related conditions such as sarcopenia and neurodegeneration. However, at present, no autophagy inducer has been established as a disease-modifyin
Iron is an essential nutrient for mitochondrial metabolic processes, including mitochondrial respiration. Ferritin complexes store excess iron and protect cells from iron toxicity. Therefore, iron stored in the ferritin complex might be utilized unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c10212736340928c538f39700e6c16
https://europepmc.org/articles/PMC6597882/
https://europepmc.org/articles/PMC6597882/
Autor:
Shinji Saiki, Naoko Kaga, Taku Hatano, Akio Mori, Manabu Funayama, Yoshiki Miura, Takashi Ueno, Yoko Imamichi, Koji Kamagata, Yuanzhe Li, Motoki Fujimaki, Yukiko Sasazawa, Sanae Souma, Shigeki Aoki, Hikari Taka, Norihiko Furuya, Shuko Nojiri, Yutaka Oji, Nobutaka Hattori, Shin-Ichi Ueno
Publikováno v:
Annals of Neurology
Objective Aging is the highest risk factor for Parkinson disease (PD). Under physiological conditions, spermidine and spermine experimentally enhance longevity via autophagy induction. Accordingly, we evaluated the ability of each polyamine metabolit
Autor:
Saiko Kazuno, Norihiko Furuya, Maya Ando, Shinji Saiki, Katsuhiko Sumiyoshi, Risa Nonaka, Soichiro Kakuta, Ayami Suzuki, Nobutaka Hattori
Publikováno v:
EMBO reports. 19
Parkin‐mediated mitophagy is a quality control pathway that selectively removes damaged mitochondria via the autophagic machinery. Autophagic receptors, which interact with ubiquitin and Atg8 family proteins, contribute to the recognition of damage