Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Norihide Higuchi"'
Autor:
Tomoaki Kurosaki, Takashi Kitahara, Shintaro Fumoto, Koyo Nishida, Kayo Yamamoto, Hiroo Nakagawa, Yukinobu Kodama, Norihide Higuchi, Tadahiro Nakamura, Hitoshi Sasaki
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 13, Iss 3 (2010)
Purpose. In this study, we developed various ternary complexes of encapsulated polyplexes and lipoplexes using chondroitin sulfate (CS) and investigated their universal usefulness for gene delivery. Methods. To prepare the cationic complexes, pDNA wa
Externí odkaz:
https://doaj.org/article/32c25b7db4a64fc5bf2ef82528e31d41
Autor:
Soshi Hayashida, Yoshihiro Mori, Shinichi Sadoh, Naoya Iwamura, Masamitsu Ichinose, Hideki Tsusima, Norihide Higuchi
Publikováno v:
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 48:136-142
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed5ef4185cd9294a0e1adb33ff467797
https://doi.org/10.5649/jjphcs.48.136
https://doi.org/10.5649/jjphcs.48.136
Autor:
Takashi Kitahara, Norihide Higuchi, Akira Tsujino, Hayato Akamatsu, Hitoshi Sasaki, Nobutaka Horie, Yohei Tateishi, Tsuyoshi Izumo
Publikováno v:
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 42:168-173
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5e58205b53f4f205c9103a905e95f46
https://doi.org/10.5649/jjphcs.42.168
https://doi.org/10.5649/jjphcs.42.168
Autor:
Hiroo Nakagawa, Kanoko Egashira, Hitoshi Sasaki, Mikiro Nakashima, Yukinobu Kodama, Takashi Kitahara, Yuiko Yatsugi, Norihide Higuchi, Tadahiro Nakamura, Takahiro Muro, Tomoaki Kurosaki
Publikováno v:
Journal of Pharmaceutical Sciences. 104(4):1470-1477
We developed a modified complex of pDNA and poly-l-lysine (PLL) by the addition of poly-l-histidine (PLH) and γ-polyglutamic acid (γ-PGA) to enhance its pH-buffering effect and suppress cytotoxicity. The binary and ternary complexes of pDNA with PL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8232725a60c735febbe776571b5a76
http://hdl.handle.net/10069/35263
http://hdl.handle.net/10069/35263
Autor:
Norihide Higuchi, Tadahiro Nakamura, Hitoshi Sasaki, Hiroo Nakagawa, Chihiro Nakasone, Kanoko Egashira, Yukinobu Kodama, Tomoaki Kurosaki, Hitomi Harasawa, Takashi Kitahara, Takahiro Muro
Publikováno v:
Biological and Pharmaceutical Bulletin. 38:23-29
The recognition of phosphatidylserine on the erythrocyte membrane mediates erythrophagocytosis by resident spleen macrophages. The application of phosphatidylserine to a gene vector may be a novel approach for splenic drug delivery. Therefore, we cho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37558249e46f77053150467ce2b06b6
https://doi.org/10.1248/bpb.b14-00478
https://doi.org/10.1248/bpb.b14-00478
Autor:
Kayoko Sato, Norihide Higuchi, Shintaro Fumoto, Kanoko Egashira, Tomoaki Kurosaki, Chikako Ohkubo, Takashi Kitahara, Hitoshi Sasaki, Yukinobu Kodama, Koyo Nishida, Tadahiro Nakamura
Publikováno v:
Journal of Drug Targeting. 23(1):43-51
Polynucleotides are anionic macromolecules which are expected to transfer into the targeted cells through specific uptake mechanisms. So, we developed polynucleotides coating complexes of plasmid DNA (pDNA) and polyethylenimine (PEI) for a secure and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce11e2f6be7334b57918042a0b1763b
http://hdl.handle.net/10069/35033
http://hdl.handle.net/10069/35033
Autor:
Masami Kuriyama, Norihide Higuchi, Takeshi Ishikawa, Satoshi Mizuta, Mihoko N. Nakashima, Kaname Ohyama, Mikiro Nakashima, Hiroki Otaki, Osamu Onomura
Publikováno v:
Drug metabolism and pharmacokinetics. 32(4)
The efficacy of the antiepileptic drug VPA is decreased by co-administered carbapenems (CBPMs). The mechanism of CBPM selective inhibition of acylpeptide hydrolase (APEH) hydrolysis of VPA-glucuronide (VPA-G) to VPA is unclear due to the lack of APEH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829246472dbd1412aecf14a3ba34e64d
https://pubmed.ncbi.nlm.nih.gov/28734645
https://pubmed.ncbi.nlm.nih.gov/28734645
Autor:
Kanoko Egashira, Tomoaki Kurosaki, Takashi Kitahara, Toyoharu Mine, Hitoshi Sasaki, Takahiro Muro, Yukinobu Kodama, Tadahiro Nakamura, Norihide Higuchi, Hiroo Nakagawa
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 87:472-479
We developed novel gene vectors composed of dendrigraft poly-l-lysine (DGL). The transgene expression efficiency of the pDNA/DGL complexes (DGL complexes) was markedly higher than that of the control pDNA/poly-l-lysine complex. However, the DGL compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3428f413110c221809ddaede888a73e2
https://doi.org/10.1016/j.ejpb.2014.04.013
https://doi.org/10.1016/j.ejpb.2014.04.013
Autor:
Kosuke Kanda, Takashi Kitahara, Yukinobu Kodama, Hitoshi Sasaki, Hiroo Nakagawa, Masanobu Imamura, Takahiro Muro, Tadahiro Nakamura, Norihide Higuchi
Publikováno v:
Biological and Pharmaceutical Bulletin. 37(4):552-559
The purpose of this study was to develop a ternary complex of plasmid DNA (pDNA) electrostatically assembled with polyamidoamine (PAMAM) dendrimer and chondroitin sulfate (CS) for effective and secure gene delivery. PAMAM dendrimers are new cationic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8134cb6c65849ada85a41c11be437a49
http://hdl.handle.net/10069/34434
http://hdl.handle.net/10069/34434
Autor:
Keisei Aki, Tomoaki Kurosaki, Yumi Shiokawa, Tadahiro Nakamura, Hiroo Nakagawa, Takahiro Muro, Hitoshi Sasaki, Yukinobu Kodama, Norihide Higuchi, Takashi Kitahara
Publikováno v:
Biological and Pharmaceutical Bulletin. 37:1274-1281
We developed a novel small interfering RNA (siRNA) delivery system using a ternary complex with polyethyleneimine (PEI) and γ-polyglutamic acid (γ-PGA), which showed silencing effect and no cytotoxicity. The binary complexes of siRNA with PEI were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19675acf37439b3f1d833211674f0ab7
https://doi.org/10.1248/bpb.b14-00058
https://doi.org/10.1248/bpb.b14-00058