Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Norihide, Yokoi"'
Autor:
Quan Yingyue, Kenji Sugawara, Harumi Takahashi, Norihide Yokoi, Kento Ohbayashi, Yusaku Iwasaki, Susumu Seino, Wataru Ogawa
Publikováno v:
Journal of Diabetes Investigation, Vol 14, Iss 6, Pp 746-755 (2023)
ABSTRACT Aims/Introduction Imeglimin is a new antidiabetic drug structurally related to metformin. Despite this structural similarity, only imeglimin augments glucose‐stimulated insulin secretion (GSIS), with the mechanism underlying this effect re
Externí odkaz:
https://doaj.org/article/912c73cff87a4997a1cfa1af12cf59fa
Autor:
Guirong Han, Harumi Takahashi, Naoya Murao, Ghupurjan Gheni, Norihide Yokoi, Yoshiyuki Hamamoto, Shun‐ichiro Asahara, Yutaka Seino, Yoshiaki Kido, Susumu Seino
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 6, Pp 920-930 (2021)
Abstract Aims/Introduction Glutamine is the most abundant amino acid in the circulation. In this study, we investigated cell signaling in the amplification of insulin secretion by glutamine. Materials and Methods Clonal pancreatic β‐cells MIN6‐K
Externí odkaz:
https://doaj.org/article/5f31d8d422264d359df183cf9bac2a7e
Autor:
Tomohide Hayami, Norihide Yokoi, Takuro Yamaguchi, Kohei Honda, Naoya Murao, Harumi Takahashi, Shujie Wang, Yusuke Seino, Hideki Kamiya, Daisuke Yabe, Ian R Sweet, Akira Mizoguchi, Jiro Nakamura, Susumu Seino
Publikováno v:
Journal of Diabetes Investigation, Vol 11, Iss 6, Pp 1434-1447 (2020)
Abstract Aims/Introduction Pancreatic islets are heterogenous. To clarify the relationship between islet heterogeneity and incretin action in the islets, we studied gene expression and metabolic profiles of non‐large and enlarged islets of the Zuck
Externí odkaz:
https://doaj.org/article/5890f1d6c1da4df0a98ae5c4ae59e065
Autor:
Naoya Murao, Norihide Yokoi, Harumi Takahashi, Tomohide Hayami, Yasuhiro Minami, Susumu Seino
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101414- (2022)
Objective: Age is a risk factor for type 2 diabetes (T2D). We aimed to elucidate whether β-cell glucose metabolism is altered with aging and contributes to T2D. Methods: We used senescence-accelerated mice (SAM), C57BL/6J (B6) mice, and ob/ob mice a
Externí odkaz:
https://doaj.org/article/a3936d5cd61f4706a23b2a895c3b8b0d
Autor:
Masatoshi Murase, Yusuke Seino, Ryuya Maekawa, Atsushi Iida, Kaori Hosokawa, Tomohide Hayami, Shin Tsunekawa, Yoji Hamada, Norihide Yokoi, Susumu Seino, Yoshitaka Hayashi, Hiroshi Arima
Publikováno v:
Journal of Diabetes Investigation, Vol 10, Iss 2, Pp 238-250 (2019)
Abstract Aims/Introduction A high‐carbohydrate diet is known to increase insulin secretion and induce obesity. However, whether or not a high‐carbohydrate diet affects β‐cell mass (BCM) has been little investigated. Materials and Methods Both
Externí odkaz:
https://doaj.org/article/a2e1437fe32748a49166a16dd0b6e4e0
Autor:
Mai Yoshida, Norihide Yokoi, Harumi Takahashi, Naoya Hatano, Tomohide Hayami, Wataru Ogawa, Susumu Seino
Publikováno v:
Biochemical and Biophysical Research Communications. 605:90-96
Patients with type 2 diabetes often exhibit impairments in both glucose-induced insulin secretion (GIIS) and incretin-induced insulin secretion (IIIS). These phenotypes are associated with altered glucose metabolism in pancreatic β-cells, although t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca02eb690704d271ad32361b49e779bc
https://doi.org/10.1016/j.bbrc.2022.03.036
https://doi.org/10.1016/j.bbrc.2022.03.036
Autor:
Tamio, Ohno, Yuki, Miyasaka, Kanta, Yoshida, Misato, Kobayashi, Fumihiko, Horio, Norihide, Yokoi, Masashi, Mizuno, Hiroshi, Ikegami
Publikováno v:
Experimental Animals. 71:510-518
Various mouse models of type 2 diabetes have been established, but few of these show early onset and persistent hyperglycemia. We have established a congenic mouse strain (NSY.B6-Tyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ee47d447851109c4bf39eac06edc28
https://doi.org/10.1538/expanim.22-0061
https://doi.org/10.1538/expanim.22-0061
Autor:
Ghupurjan Gheni, Guirong Han, Susumu Seino, Yutaka Seino, Naoya Murao, Shun-ichiro Asahara, Norihide Yokoi, Yoshiyuki Hamamoto, Yoshiaki Kido, Harumi Takahashi
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 6, Pp 920-930 (2021)
Journal of Diabetes Investigation
Journal of Diabetes Investigation
Aims/Introduction Glutamine is the most abundant amino acid in the circulation. In this study, we investigated cell signaling in the amplification of insulin secretion by glutamine. Materials and Methods Clonal pancreatic β‐cells MIN6‐K8, wild
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b9e66f0b4621036ac6801e3f3f3cbf
http://www.lib.kobe-u.ac.jp/handle_kernel/90008394
http://www.lib.kobe-u.ac.jp/handle_kernel/90008394
Autor:
Naoya Murao, Norihide Yokoi, Kohei Honda, Guirong Han, Tomohide Hayami, Ghupurjan Gheni, Harumi Takahashi, Kohtaro Minami, Susumu Seino
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187213 (2017)
Incretins (GLP-1 and GIP) potentiate insulin secretion through cAMP signaling in pancreatic β-cells in a glucose-dependent manner. We recently proposed a mechanistic model of incretin-induced insulin secretion (IIIS) that requires two critical proce
Externí odkaz:
https://doaj.org/article/0d5dfbcc99b7490f811aac96ca1a34db
Autor:
Ghupurjan Gheni, Masahito Ogura, Masahiro Iwasaki, Norihide Yokoi, Kohtaro Minami, Yasumune Nakayama, Kazuo Harada, Benoit Hastoy, Xichen Wu, Harumi Takahashi, Kazushi Kimura, Toshiya Matsubara, Ritsuko Hoshikawa, Naoya Hatano, Kenji Sugawara, Tadao Shibasaki, Nobuya Inagaki, Takeshi Bamba, Akira Mizoguchi, Eiichiro Fukusaki, Patrik Rorsman, Susumu Seino
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 661-673 (2014)
Incretins, hormones released by the gut after meal ingestion, are essential for maintaining systemic glucose homeostasis by stimulating insulin secretion. The effect of incretins on insulin secretion occurs only at elevated glucose concentrations and
Externí odkaz:
https://doaj.org/article/63c84696f9bd4fb8a77b9baf72fed23b