Výsledky vyhledávání - "Norifumi Sakai"

Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver

Autor: Norifumi Sakai, Masatomo Goto, Hiroshi Yamazaki, Hiroshi Iwata, Hiroshi Suemizu

Publikováno v: Xenobiotica. 49:1311-1322

1. In order to investigate the pharmacokinetics of diisononyl phthalate (DINP) in humans, we administered [phenyl-U-14C]DINP at a dose of 50.0 mg/kg orally to chimeric mice (humanized-liver...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91968a9d80d9a53ac799135ece54a5c4
https://doi.org/10.1080/00498254.2018.1564087

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Human urinary concentrations of monoisononyl phthalate estimated using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in humanized-liver mice orally administered with diisononyl phthalate

Autor: Masatomo Goto, Hiroshi Suemizu, Tomonori Miura, Hiroshi Iwata, Makiko Shimizu, Hiroshi Yamazaki, Norifumi Sakai

Publikováno v: Xenobiotica. 49:513-520

Diisononyl phthalate (DINP) used as a plasticizer is a mixture of compounds consisting of isononyl esters of phthalic acid. There are concerns about the bioaccumulation of such esters in humans. A [phenyl-U-14C]DINP mixture was synthesized and orally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395fca5b6d9e643513d2ede429a2ff59
https://doi.org/10.1080/00498254.2018.1471753

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Impact of Intestinal Glucuronidation on the Pharmacokinetics of Raloxifene

Autor: Yuya Endo, Naomi Takeba, Keigo Kosaka, Minoru Tsuda-Tsukimoto, Toshiyuki Kume, Tomohiko Tanimoto, Norifumi Sakai, Masakatsu Takahashi, Ichiro Kino, Tatsuyuki Ohtsuka, Yuga Fukuhara

Publikováno v: Drug Metabolism and Disposition. 39:1495-1502

Raloxifene is extensively glucuronidated in humans, effectively reducing its oral bioavailability (2%). It was also reported to be glucuronidated in preclinical animals, but its effects on the oral bioavailability have not been fully elucidated. In t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5d0774ec2b1f1eb66e1904f6e10242
https://doi.org/10.1124/dmd.111.040030

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Structural and ligand‐binding properties of serum albumin species interacting with a biomembrane interface

Autor: Naoko Yonemura, Masaki Otagiri, Toru Maruyama, Koji Nishi, Ayaka Suenaga, Norifumi Sakai, Takamitsu Kosa, Hiroshi Watanabe

Publikováno v: Journal of Pharmaceutical Sciences. 96:3117-3124

In the process of drug development, preclinical testing using experimental animals is an important aspect, for verification of the efficacy and safety of a drug. Serum albumin is a major binding protein for endogenous and exogenous ligands and regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c89a3848337341644303d0b9af4e28a
https://doi.org/10.1002/jps.20887

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Absorption and metabolism of glycosidic sweeteners of stevia mixture and their aglycone, steviol, in rats and humans

Autor: Kunio Kakegawa, Osamu Izawa, Michio Ui, Eriko Koyama, Akiharu Fujino, Yuji Ohori, Norifumi Sakai, Ken Kitazawa

Publikováno v: Food and Chemical Toxicology. 41:875-883

Stevia mixture, sweeteners extracted from the leaves of Stevia rebaudiana Bertoni, consists mainly of the glycosides of the diterpene derivative steviol. The aims of this study were to investigate the absorption (in rats) and the hepatic metabolism (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa2986682474188c9214c883c4efbb6
https://doi.org/10.1016/s0278-6915(03)00039-5

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Structural and drug-binding properties of α1-acid glycoprotein in reverse micelles

Autor: Yoshio Komine, Toru Maruyama, Masaki Otagiri, Koji Nishi, H. Brian Halsall, Norifumi Sakai

Publikováno v: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1601:185-191

Alpha(1)-acid glycoprotein (AGP) is a glycoprotein that consists of 183 amino acid residues and five carbohydrate chains and binds to neutral and basic drugs. We examined the structural properties and ligand-binding capacity of AGP in interactions wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd7c310470c825b856dd34a38603bfd
https://doi.org/10.1016/s1570-9639(02)00465-x

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[Untitled]

Autor: Takamitsu Kosa, Norifumi Sakai, Shoji Yahara, Toru Maruyama, Masaki Otagiri, Naoko Yonemura

Publikováno v: Pharmaceutical Research. 15:592-598

Purpose. The aim of this study was to investigate the characteristics of the structural transitions and changes in ligand binding properties of different albumins during the pH-dependent structural transition, often referred to as the N-B transition.

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https://doi.org/10.1023/a:1011986028529

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Cooperative effect of hydrophobic and electrostatic forces on alcohol-induced alpha-helix formation of alpha1-acid glycoprotein

Autor: Masaki Otagiri, Yoshio Komine, Koji Nishi, Toru Maruyama, Norifumi Sakai

Publikováno v: FEBS letters. 579(17)

Alpha1-acid glycoprotein (AGP) is a serum glycoprotein that mainly binds basic drugs. Previous reports have shown that AGP converts from a beta-sheet to an alpha-helix upon interaction with biomembranes. In the current studies, we found that alkanols

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd475ad20de0251783f34888cc94bc4
https://pubmed.ncbi.nlm.nih.gov/15963986

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