Výsledky vyhledávání - "Norifumi, Morikawa"

Akademický článek

Pharmacokinetic/pharmacodynamic evaluation of teicoplanin against Staphylococcus aureus in a murine thigh infection model

Autor: Erika Watanabe, Kazuaki Matsumoto, Kazuro Ikawa, Yuta Yokoyama, Akari Shigemi, Yuki Enoki, Yasuhiro Umezaki, Koyo Nakamura, Keiichiro Ueno, Hideyuki Terazono, Norifumi Morikawa, Yasuo Takeda

Publikováno v: Journal of Global Antimicrobial Resistance, Vol 24, Iss , Pp 83-87 (2021)

Objectives: Pharmacokinetic/pharmacodynamic (PK/PD) analysis using murine infection models is a well-established methodology for optimising antimicrobial therapy. Therefore, we investigated the PK/PD indices of teicoplanin againstStaphylococcus aureu

Externí odkaz: https://doaj.org/article/074a031110824a18ab1ea363f3b857a3

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Akademický článek

Pulmonary Pharmacokinetic and Pharmacodynamic Evaluation of Ampicillin/Sulbactam Regimens for Pneumonia Caused by Various Bacteria, including Acinetobacter baumannii

Autor: Tetsushu Onita, Kazuro Ikawa, Noriyuki Ishihara, Hiroki Tamaki, Takahisa Yano, Kohji Naora, Norifumi Morikawa

Publikováno v: Antibiotics, Vol 12, Iss 2, p 303 (2023)

This study aimed to assess the dosing regimens of ampicillin/sulbactam for pneumonia based on pulmonary pharmacokinetic (PK)/pharmacodynamic (PD) target attainment. Using the literature data, we developed pulmonary PK models and estimated the probabi

Externí odkaz: https://doaj.org/article/0d79a52d3dbd4783b3b902d59a8418b7

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Akademický článek

Concentration-Dependent Activity of Pazufloxacin against Pseudomonas aeruginosa: An In Vivo Pharmacokinetic/Pharmacodynamic Study

Autor: Yasuhiro Umezaki, Kazuaki Matsumoto, Kazuro Ikawa, Yuta Yokoyama, Yuki Enoki, Akari Shigemi, Erika Watanabe, Koyo Nakamura, Keiichiro Ueno, Hideyuki Terazono, Norifumi Morikawa, Yasuo Takeda

Publikováno v: Antibiotics, Vol 11, Iss 7, p 982 (2022)

The bacterium Pseudomonas aeruginosa is known to be associated with nosocomial infections around the world. Pazufloxacin, a potent DNA gyrase inhibitor, is known to be an effective drug candidate. However, it has not been clarified whether the pharma

Externí odkaz: https://doaj.org/article/e687c3b1dc6a46fab35f201068aa9fb1

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Ceftolozane–Tazobactam Pharmacokinetics in the Abdominal Tissue of Patients Undergoing Lower Gastrointestinal Surgery: Dosing Considerations Based on Site-Specific Pharmacodynamic Target Attainment

Autor: Kosuke Yoshimura, Hiroki Ohge, Kazuro Ikawa, Shinnosuke Uegami, Yusuke Watadani, Norifumi Shigemoto, Toshinori Hirano, Hiroki Kitagawa, Yuki Kaiki, Norifumi Morikawa, Shinya Takahashi

Publikováno v: Infectious Diseases and Therapy. 12:193-207

Recently, complicated intra-abdominal infections (cIAI) have been caused not only by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Pseudomonas aeruginosa, but also by extended-spectrum β-lactamase-producing Enterobacterales memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b569b1b91a75977a348de91598986f
https://doi.org/10.1007/s40121-022-00720-x

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Pharmacodynamic Evaluation of Ampicillin-sulbactam in Pediatric Patients Using Plasma and Urine Data

Autor: Tetsushu Onita, Kazuro Ikawa, Noriyuki Ishihara, Hiroki Tamaki, Takahisa Yano, Kohji Naora, Norifumi Morikawa

Publikováno v: Pediatric Infectious Disease Journal. 41:411-416

We aimed to develop population pharmacokinetic (PK) models of ampicillin and sulbactam using pooled data analysis and to optimize dosing regimens of ampicillin-sulbactam (combination ratio of 2:1) in pediatric patients.Population PK models of ampicil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7d9db2025023f19a121a023ca117ba
https://doi.org/10.1097/inf.0000000000003496

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Akademický článek

Population Pharmacokinetic Modeling and Pharmacodynamic Target Attainment Simulation of Piperacillin/Tazobactam for Dosing Optimization in Late Elderly Patients with Pneumonia

Autor: Noriyuki Ishihara, Nobuhiro Nishimura, Kazuro Ikawa, Fumi Karino, Kiyotaka Miura, Hiroki Tamaki, Takahisa Yano, Takeshi Isobe, Norifumi Morikawa, Kohji Naora

Publikováno v: Antibiotics, Vol 9, Iss 3, p 113 (2020)

The aim of this study was to develop a population pharmacokinetic model for piperacillin (PIPC)/tazobactam (TAZ) in late elderly patients with pneumonia and to optimize the administration planning by applying pharmacokinetic/pharmacodynamic (PK/PD) c

Externí odkaz: https://doaj.org/article/474fde183f65439c94434d4bcc2f6ad8

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Pharmacokinetics of cefmetazole in plasma, peritoneal fluid, peritoneum, and subcutaneous adipose tissue of patients scheduled for lower gastrointestinal surgery: Dosing considerations based on site-specific pharmacodynamic target attainment

Autor: Yuki Kaiki, Hiroki Ohge, Kazuro Ikawa, Shinnosuke Uegami, Yusuke Watadani, Norifumi Shigemoto, Toshinori Hirano, Kosuke Yoshimura, Hiroki Kitagawa, Norifumi Morikawa, Shinya Takahashi

Publikováno v: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

Cefmetazole (CMZ) has gained interest as a carbapenem-sparing alternative to the epidemic of extended-spectrum β-lactamase (ESBL)-producing Enterobacterales (ESBL-E). In this study, we investigated the pharmacokinetics (PK) of CMZ in plasma, periton

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ec66b9a539cfc97997464b68b91f3d
https://pubmed.ncbi.nlm.nih.gov/36549644

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Pharmacokinetics of flomoxef in plasma, peritoneal fluid, peritoneum, and subcutaneous adipose tissue of patients undergoing lower gastrointestinal surgery: Dosing considerations based on site-specific pharmacodynamic target attainment

Autor: Toshinori Hirano, Hiroki Ohge, Kazuro Ikawa, Shinnosuke Uegami, Yusuke Watadani, Norifumi Shigemoto, Kosuke Yoshimura, Hiroki Kitagawa, Yuki Kaiki, Norifumi Morikawa, Shinya Takahashi

Publikováno v: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

Flomoxef is generally used to treat abdominal infections and as antibiotic prophylaxis during lower gastrointestinal surgery. It is reportedly effective against extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae and an increasingly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8196fdd42af1d60e9bd1fc5f5577a9
https://pubmed.ncbi.nlm.nih.gov/36341996

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Dosing Optimization of Ampicillin-Sulbactam Based on Cystatin C in Elderly Patients with Pneumonia

Autor: Yuta Yokoyama, Yasuo Takeda, Norifumi Morikawa, Akari Shigemi, Tamao Ohshige, Kazuaki Matsumoto, Erika Watanabe, Kazuro Ikawa, Hideyuki Terazono, Yuki Enoki, Kayoko Matsubara

Publikováno v: Biological and Pharmaceutical Bulletin. 44:732-736

Ampicillin-sulbactam is a first-line therapy for pneumonia and is mainly excreted by the kidney. It is important to optimize the dose and dosing interval of ampicillin-sulbactam because in patients with decreased renal function and low skeletal muscl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e0d2cecec3d07a177b281485665698
https://doi.org/10.1248/bpb.b20-00781

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