Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Noriatsu Shigemura"'
Autor:
Ayaka Hirayama, Shusuke Iwata, Asami Oike, Yuko Kawabata, Yuki Nagasato, Shingo Takai, Keisuke Sanematsu, Ichiro Takahashi, Noriatsu Shigemura
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Drug-induced taste disorders are a serious problem in an aging society. This study investigated the mechanisms underlying taste disturbances induced by diclofenac, a non-steroidal anti-inflammatory drug that reduces pain and inflammation by inhibitin
Externí odkaz:
https://doaj.org/article/a3b86b1bb01c4e74b6cbfd49c7018883
Autor:
Keisuke Sanematsu, Masato Yamamoto, Yuki Nagasato, Yuko Kawabata, Yu Watanabe, Shusuke Iwata, Shingo Takai, Kiyoshi Toko, Toshiro Matsui, Naohisa Wada, Noriatsu Shigemura
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Molecular dynamics simulations and functional assays of the transmembrane domain of the sweet taste receptor subunit, TAS1R3 reveal mechanisms on the allostery of sweet receptor activation or inactivation and pH-dependent sensitivity to saccharin.
Externí odkaz:
https://doaj.org/article/46650d6086da41119a00c18ee33b4864
Autor:
Asami Oike, Shusuke Iwata, Ayaka Hirayama, Yurika Ono, Yuki Nagasato, Yuko Kawabata, Shingo Takai, Keisuke Sanematsu, Naohisa Wada, Noriatsu Shigemura
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Little is known about the molecular mechanisms underlying drug-induced taste disorders, which can cause malnutrition and reduce quality of life. One of taste disorders is known adverse effects of bisphosphonates, which are administered as an
Externí odkaz:
https://doaj.org/article/748b2fb374f84d76a2607013d773d604
Autor:
Yuna Lee, Akihiro Nakano, Saya Nakamura, Kenta Sakai, Mitsuru Tanaka, Keisuke Sanematsu, Noriatsu Shigemura, Toshiro Matsui
Publikováno v:
npj Science of Food, Vol 5, Iss 1, Pp 1-10 (2021)
Abstract The aim of this study is to develop a dipeptide showing an adiponectin receptor 1 (AdipoR1) agonistic effect in skeletal muscle L6 myotubes. Based on the structure of the AdipoR1 agonist, AdipoRon, 15 synthetic dipeptides were targeted to pr
Externí odkaz:
https://doaj.org/article/d6a6f6a590ac47a8ae6ba0208904792b
Autor:
Shusuke Iwata, Ryusuke Yoshida, Shingo Takai, Keisuke Sanematsu, Noriatsu Shigemura, Yuzo Ninomiya
Publikováno v:
Nutrients, Vol 15, Iss 13, p 2941 (2023)
On the tongue, the T1R-independent pathway (comprising glucose transporters, including sodium–glucose cotransporter (SGLT1) and the KATP channel) detects only sugars, whereas the T1R-dependent (T1R2/T1R3) pathway can broadly sense various sweetener
Externí odkaz:
https://doaj.org/article/d0a0866b88c94a1d96f903006ca98219
Autor:
Joan Serrano, Jaroslava Seflova, Jihye Park, Marsha Pribadi, Keisuke Sanematsu, Noriatsu Shigemura, Vanida Serna, Fanchao Yi, Andrea Mari, Erik Procko, Richard E. Pratley, Seth L. Robia, George A. Kyriazis
Publikováno v:
Molecular Metabolism, Vol 54, Iss , Pp 101339- (2021)
Objective: Sweet taste receptors (STR) are expressed in the gut and other extra-oral tissues, suggesting that STR-mediated nutrient sensing may contribute to human physiology beyond taste. A common variant (Ile191Val) in the TAS1R2 gene of STR is ass
Externí odkaz:
https://doaj.org/article/1acbd0e244fc4d53855f831ccf780d78
Autor:
Shingo Takai, Yu Watanabe, Keisuke Sanematsu, Ryusuke Yoshida, Robert F Margolskee, Peihua Jiang, Ikiru Atsuta, Kiyoshi Koyano, Yuzo Ninomiya, Noriatsu Shigemura
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225190 (2019)
Expression of insulin and its receptor (IR) in rodent taste cells has been proposed, but exactly which types of taste cells express IR and the function of insulin signaling in taste organ have yet to be determined. In this study, we analyzed expressi
Externí odkaz:
https://doaj.org/article/867b31370ad047b8845f279eb24b0d8f
Autor:
Ayana Osaki, Keisuke Sanematsu, Junichi Yamazoe, Fumie Hirose, Yu Watanabe, Yuko Kawabata, Asami Oike, Ayaka Hirayama, Yu Yamada, Shusuke Iwata, Shingo Takai, Naohisa Wada, Noriatsu Shigemura
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 8958 (2020)
Taste disorders are common adverse effects of cancer chemotherapy that can reduce quality of life and impair nutritional status. However, the molecular mechanisms underlying chemotherapy-induced taste disorders remain largely unknown. Furthermore, th
Externí odkaz:
https://doaj.org/article/1781fa4dd60745da8559a0d9d8bc6921
Autor:
Noriatsu Shigemura, DDS, PhD
Publikováno v:
Japanese Dental Science Review, Vol 51, Iss 2, Pp 51-58 (2015)
The sense of taste plays a major role in evaluating the quality of food components in the oral cavity. Sweet, salty, umami, sour and bitter taste are generally accepted as five basic taste qualities. Among them, salty taste is attractive to animals a
Externí odkaz:
https://doaj.org/article/ba114e507ebe4ba1ab69cd8274364edf
Autor:
Ryusuke Yoshida, Misa Shin, Keiko Yasumatsu, Shingo Takai, Mayuko Inoue, Noriatsu Shigemura, Soichi Takiguchi, Seiji Nakamura, Yuzo Ninomiya
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Cholecystokinin (CCK) is a gut hormone released from enteroendocrine cells. CCK functions as an anorexigenic factor by acting on CCK receptors expressed on the vagal afferent nerve and hypothalamus with a synergistic interaction between leptin. In th
Externí odkaz:
https://doaj.org/article/e3ab94e991514983b8cf90180fddeef6