Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Norelle C. Wildburger"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Cumulative evidence collected in recent decades suggests that lysosomal dysfunction contributes to neurodegenerative diseases, especially if amyloid proteins are involved. Among these, alpha-synuclein (aSyn) that progressively accumulates and aggrega
Externí odkaz:
https://doaj.org/article/7e43dc0e4925496c812d2e5c718fb29b
Autor:
Federico Scala, Miroslav N. Nenov, Elizabeth J. Crofton, Aditya K. Singh, Oluwarotimi Folorunso, Yafang Zhang, Brent C. Chesson, Norelle C. Wildburger, Thomas F. James, Musaad A. Alshammari, Tahani K. Alshammari, Hannah Elfrink, Claudio Grassi, James M. Kasper, Ashley E. Smith, Jonathan D. Hommel, Cheryl F. Lichti, Jai S. Rudra, Marcello D’Ascenzo, Thomas A. Green, Fernanda Laezza
Publikováno v:
Cell Reports, Vol 23, Iss 2, Pp 555-567 (2018)
Summary: Resilience and vulnerability to neuropsychiatric disorders are linked to molecular changes underlying excitability that are still poorly understood. Here, we identify glycogen-synthase kinase 3β (GSK3β) and voltage-gated Na+ channel Nav1.6
Externí odkaz:
https://doaj.org/article/dc94cfdd1eef4764a9b23adba0a07db4
Autor:
Norelle C. Wildburger, Frank Gyngard, Christelle Guillermier, Bruce W. Patterson, Donald Elbert, Kwasi G. Mawuenyega, Theresa Schneider, Karen Green, Robyn Roth, Robert E. Schmidt, Nigel J. Cairns, Tammie L. S. Benzinger, Matthew L. Steinhauser, Randall J. Bateman
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Alzheimer’s disease (AD) is a neurodegenerative disorder with clinical manifestations of progressive memory decline and loss of executive function and language. AD affects an estimated 5.3 million Americans alone and is the most common form of age-
Externí odkaz:
https://doaj.org/article/e8889b5e11ca4547a4690367b0f4d955
Autor:
Norelle C. Wildburger, Cheryl F. Lichti, Richard D. LeDuc, Mary Schmidt, Roger A. Kroes, Joseph R. Moskal, Carol L. Nilsson
Publikováno v:
EuPA Open Proteomics, Vol 8, Iss C, Pp 94-103 (2015)
Bone marrow-derived human mesenchymal stem cells (BM-hMSCs) show promise as cell-based delivery vehicles for anti-glioma therapeutics, due to innate tropism for gliomas. However, in clinically relevant human-in-mouse glioma stem cell xenograft models
Externí odkaz:
https://doaj.org/article/1246121ec9ef4c82972fd2a1cebfd6f9
Autor:
Cheryl F. Lichti, Norelle C. Wildburger, Alexander S. Shavkunov, Ekaterina Mostovenko, Huiling Liu, Erik P. Sulman, Carol L. Nilsson
Publikováno v:
EuPA Open Proteomics, Vol 8, Iss C, Pp 85-93 (2015)
Glioma stem-like cells (GSCs) are hypothesized to provide a repository of cells in tumors that can self-replicate and are radio- and chemo-resistant. GSC lines, representing several glioma subtypes, have been isolated and characterized at the transcr
Externí odkaz:
https://doaj.org/article/e4ebd1550ff149ed96ff743523da31fa
Autor:
Randall J. Bateman, Nicolas R. Barthélemy, Audrey Gabelle, Tim West, Henrik Zetterberg, Kevin E. Yarasheski, Bruce W. Patterson, Selina Wray, Nick C. Fox, Jonathan D. Rohrer, Donald L. Elbert, Timothy M. Miller, Norelle C. Wildburger, Sylvain Lehmann, Claire A Leckey, Chihiro Sato, Jonathan M. Schott, Brendan P. Lucey, Christophe Hirtz, Ross W. Paterson, Celeste M. Karch
Publikováno v:
Nature Reviews Neurology
Nature Reviews Neurology, Nature Publishing Group, 2019, 15 (7), pp.419-427. ⟨10.1038/s41582-019-0222-0⟩
Nature Reviews Neurology, Nature Publishing Group, 2019, 15 (7), pp.419-427. ⟨10.1038/s41582-019-0222-0⟩
Alzheimer disease (AD) is one of several neurodegenerative diseases characterized by dysregulation, misfolding and accumulation of specific proteins in the CNS. The stable isotope labelling kinetics (SILK) technique is based on generating amino acids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3191148ca7b2f56dd7cb3be5e2db8615
https://doi.org/10.1038/s41582-019-0222-0
https://doi.org/10.1038/s41582-019-0222-0
Autor:
Sam Hughes, Nicolas L. Young, David Clarke, Frank Sobott, Anja Resemann, Kristina Srzentić, Kim F. Haselmann, Detlev Suckau, Dina L. Bai, Young Ah Goo, Christian Malosse, Mathieu Dupré, Sylvester M. Greer, Neil R. Quebbemann, Ziqing Lin, Jared B. Shaw, Alain Beck, Yury O. Tsybin, Stuart Pengelley, Timothy K. Toby, Lidong He, Paul O. Danis, Henrique S. Seckler, Robert Anthony D’Ippolito, Natalia Gasilova, Jeffrey N. Agar, Donald F. Hunt, Jennifer S. Brodbelt, Matthew V. Holt, Simone Nicolardi, Joseph A. Loo, Yuri E. M. van der Burgt, Nicholas D. Schmitt, Laure Menin, Robert J. Millikin, Ljiljana Paša-Tolić, David R. Goodlett, Mowei Zhou, Joshua D. Hinkle, Michael R. Shortreed, Christopher L. Hendrickson, Wendy Sandoval, Richa Sarin, Jeffrey Shabanowitz, Alan G. Marshall, Anton N. Kozhinov, Neil L. Kelleher, Chad R. Weisbrod, Lissa C. Anderson, Julia Chamot-Rooke, Yunqiu Chen, John R. Yates, Luca Fornelli, Konstantin O. Nagornov, Lloyd M. Smith, Sneha Chatterjee, Ying Ge, Sung Hwan Yoon, Jolene K. Diedrich, Norelle C. Wildburger
Publikováno v:
Journal of The American Society for Mass Spectrometry
Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2020, 31 (9), pp.1783-1802. ⟨10.1021/jasms.0c00036⟩
Journal of the American Society for Mass Spectrometry
Journal of the American Society for Mass Spectrometry, vol 31, iss 9
Journal of The American Society for Mass Spectrometry, 31(9), 1783-1802. AMER CHEMICAL SOC
J Am Soc Mass Spectrom
Journal of The American Society for Mass Spectrometry, 2020, 31 (9), pp.1783-1802. ⟨10.1021/jasms.0c00036⟩
Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2020, 31 (9), pp.1783-1802. ⟨10.1021/jasms.0c00036⟩
Journal of the American Society for Mass Spectrometry
Journal of the American Society for Mass Spectrometry, vol 31, iss 9
Journal of The American Society for Mass Spectrometry, 31(9), 1783-1802. AMER CHEMICAL SOC
J Am Soc Mass Spectrom
Journal of The American Society for Mass Spectrometry, 2020, 31 (9), pp.1783-1802. ⟨10.1021/jasms.0c00036⟩
International audience; The Consortium for Top-Down Proteomics (www.topdownproteomics.org) launched the present study to assess the current state of top-down mass spectrometry (TD MS) and middle-down mass spectrometry (MD MS) for characterizing monoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce93ac618ef03bef2381fe00d09bf9cf
https://hdl.handle.net/1887/3182316
https://hdl.handle.net/1887/3182316
Autor:
Musaad A. Alshammari, Cheryl F. Lichti, Aditya K. Singh, Marcello D'Ascenzo, Miroslav N. Nenov, Tahani K. Alshammari, Brent C. Chesson, Jonathan D. Hommel, Ashley E. Smith, Elizabeth J. Crofton, Jai S. Rudra, Thomas F. James, Thomas A. Green, James M. Kasper, Claudio Grassi, Norelle C. Wildburger, Hannah Elfrink, Oluwarotimi Folorunso, Yafang Zhang, Federico Scala, Fernanda Laezza
Publikováno v:
Cell reports
Cell Reports, Vol 23, Iss 2, Pp 555-567 (2018)
Cell Reports, Vol 23, Iss 2, Pp 555-567 (2018)
SUMMARY Resilience and vulnerability to neuropsychiatric disorders are linked to molecular changes underlying excitability that are still poorly understood. Here, we identify glycogen-synthase kinase 3β (GSK3β) and voltage-gated Na+ channel Nav1.6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e19825dc2cd7ff27f924588bda8da2
https://doi.org/10.1016/j.celrep.2018.03.062
https://doi.org/10.1016/j.celrep.2018.03.062
Autor:
Norelle C. Wildburger, Randall J. Bateman, Robert E. Schmidt, Melissa Sullivan, Wendy Sigurdson, Greg S. Day, Amanda Peters
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f22acd0a57751b6ec0300e087b28c623
https://doi.org/10.1016/j.jalz.2018.06.1427
https://doi.org/10.1016/j.jalz.2018.06.1427
Publikováno v:
Brain
The primary structure of canonical amyloid-β-protein was elucidated more than 30 years ago, yet the forms of amyloid-β that play a role in Alzheimer's disease pathogenesis remain poorly defined. Studies of Alzheimer's disease brain extracts suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccecef805e188e03f530d5a38d0a187
https://doi.org/10.1093/brain/awz082
https://doi.org/10.1093/brain/awz082