Výsledky vyhledávání - "Noreen Sheehy"

The ESCRT-0 Protein HRS Interacts with the Human T Cell Leukemia Virus Type 2 Antisense Protein APH-2 and Suppresses Viral Replication

Autor: Fanny Martini, William W. Hall, Coline Arone, Noreen Sheehy, Amy Hasset

Publikováno v: J Virol

The divergent clinical outcomes of human T cell leukemia virus type 1 (HTLV-1) and HTLV-2 infections have been attributed to functional differences in their antisense proteins. In contrast to HTLV-1 bZIP factor (HBZ), the role of the antisense protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae3744c9f02b84854b96610e04487bb
https://pubmed.ncbi.nlm.nih.gov/31597781

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Novel Interactions between the Human T-Cell Leukemia Virus Type 1 Antisense Protein HBZ and the SWI/SNF Chromatin Remodeling Family: Implications for Viral Life Cycle

Autor: William W. Hall, Noreen Sheehy, Alasiri A, Abboud Guerr J

The human T-cell leukemia virus type 1 (HTLV-1) regulatory proteins Tax and HBZ play indispensable roles in regulating viral and cellular gene expression. BRG1, the ATPase subunit of the SWI/SNF chromatin remodeling complex, has been demonstrated to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e736c5ce288e2d30259e3d5c7c786a2
https://europepmc.org/articles/PMC6675893/

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Novel interactions between the HTLV antisense proteins HBZ and APH-2 and the NFAR protein family: Implications for the HTLV lifecycles

Autor: Noreen Sheehy, William W. Hall, Jane L Murphy, Lee Ratner

Publikováno v: Virology. 494:129-142

The human T-cell leukaemia virus type 1 and type 2 (HTLV-1/HTLV-2) antisense proteins HBZ and APH-2 play key roles in the HTLV lifecycles and persistence in the host. Nuclear Factors Associated with double-stranded RNA (NFAR) proteins NF90/110 functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab9875c1f6343a828af5f8db69ec81e
https://doi.org/10.1016/j.virol.2016.04.012

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Anchorage-dependent multicellular aggregate formation induces CD44 high cancer stem cell-like ATL cells in an NF-κB- and vimentin-dependent manner

Autor: William W. Hall, Masanori Kasahara, Yukiko Miyatake, Noreen Sheehy, Shunji Ikeshita

Publikováno v: Cancer Letters. 357:355-363

Adult T-cell leukemia/lymphoma (ATL) is an intractable T-cell malignancy accompanied by massive invasion of lymphoma cells into various tissues. We demonstrate here that ATL cells cultured on a layer of epithelial-like feeder cells form anchorage-dep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6667dd1ec7ef65dec121e310c6bf0ac
https://doi.org/10.1016/j.canlet.2014.11.055

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Positive and Negative Regulation of Type I Interferons by the Human T Cell Leukemia Virus Antisense Protein HBZ

Autor: Lucie Charmier, William W. Hall, Manraj Singh Narulla, Stephen Noonan, David Conroy, Noreen Sheehy, Ahlam Alsairi

Publikováno v: Journal of virology. 91(20)

The pathogenesis of human T cell leukemia virus type 1 (HTLV-1) is strongly linked to the viral regulatory proteins Tax1 and HBZ, whose opposing functions contribute to the clinical outcome of infection. Type I interferons alpha and beta (IFN-α and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c8b833d022825656ec6f3a7873ab54
https://pubmed.ncbi.nlm.nih.gov/29295960

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EGF Uptake and Degradation Assay to Determine the Effect of HTLV Regulatory Proteins on the ESCRT-Dependent MVB Pathway

Autor: Colin, Murphy, Noreen, Sheehy

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1582

The endosomal sorting complex required for transport (ESCRT) pathway plays key roles in multivesicular bodies (MVBs) formation and lysosomal degradation of membrane receptors, viral budding, and midbody abscission during cytokinesis. The epidermal gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee7a9396f3837d58a85857ededc636ba
https://pubmed.ncbi.nlm.nih.gov/28357665

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The Four and a Half LIM Family Members Are Novel Interactants of the Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein

Autor: Áine McCabe, Kenichi Hashimoto, William W. Hall, Noreen Sheehy

Publikováno v: Journal of Virology. 87:7435-7444

Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia (ATL). The viral regulatory protein Tax1 plays a pivotal role in T-cell transformation and ATL development. Previous studies in our laboratory, using the yeas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e999ab8b81ebd8e6c6117dfa5995f3
https://doi.org/10.1128/jvi.00070-13

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Tax 1-Independent Induction of Vascular Endothelial Growth Factor in Adult T-Cell Leukemia Caused by Human T-Cell Leukemia Virus Type 1

Autor: William W. Hall, Virginie Gautier, Noreen Sheehy, Jonathan Dean, Karen M. Watters

Publikováno v: Journal of Virology. 84:5222-5228

Adult T-cell leukemia (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1). Elevated expression of vascular endothelial growth factor (VEGF) in ATL patients is associated with leukemic cell invasion and infiltration in different organs. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df42d5551a251a22ac6fb9893e4f1bd
https://doi.org/10.1128/jvi.02166-09

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