Výsledky vyhledávání - "Noreen Sabir"

Five Most Common Prognostically Important Fusion Oncogenes are Detected in the Majority of Pakistani Pediatric Acute Lymphoblastic Leukemia Patients and are Strongly Associated with Disease Biology and Treatment Outcome

Publikováno v: Europe PubMed Central

BACKGROUND AND OBJECTIVES: Acute lymphoblastic leukemia (ALL) is a complex genetic disease involving many fusion oncogenes (FO) having prognostic significance. The frequency of various FO can vary in different ethnic groups, with important implicatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77882820e5dfc7e6454f646959c209cf
https://doi.org/10.7314/apjcp.2012.13.11.5469

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Prognostically Significant Fusion Oncogenes in Pakistani Patients with Adult Acute Lymphoblastic Leukemia and their Association with Disease Biology and Outcome

Publikováno v: Europe PubMed Central

Background and objectives: Chromosomal abnormalities play an important role in genesis of acute lymphoblastic leukemia (ALL) and have prognostic implications. Five major risk stratifying fusion genes in ALL are BCR-ABL, MLL-AF4, ETV6-RUNX11, E2A-PBX1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de27eec05bcf3255235465b87426d0d
https://doi.org/10.7314/apjcp.2012.13.7.3349

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High frequency and poor prognosis of late childhood BCR-ABL-positive and MLL-AF4-positive ALL define the need for advanced molecular diagnostics and improved therapeutic strategies in pediatric B-ALL in Pakistan

Publikováno v: Molecular diagnosistherapy. 19(5)

BACKGROUND: Fusion oncogenes (FOs) resulting from chromosomal abnormalities have an important role in leukemogenesis in pediatric B cell acute lymphoblastic leukemia (ALL). The most common FOs are BCR-ABL, MLL-AF4, ETV6-RUNX1, and TCF3-PBX1, all of w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3faf2720c7e19a4645c173d74024d945
https://pubmed.ncbi.nlm.nih.gov/26266519

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Abstract 564: Favorable prognostic features at diagnosis along with young age, early remission, high relapse rate and poor survival of TCF3-PBX1 positive adult ALL necessitates the need for differential genetic diagnosis and treatment using pediatric ALL protocols

Autor: Zafar Iqbal, Noreen Sabir, Tanveer Akhtar, Aamer Aleem, Mudassar Iqbal, Ahmad Mukhtar Khalid, Tashfeen Khalid Awan, Mahmood Rasool, Salman Basit

Publikováno v: Cancer Research. 74:564-564

Introduction: ALL involves many genetic abnormalities, many of which lead to formation of fusion oncogenes (FGs) causing leukemogenesis1. Role of FGs in prognosis and drug selection is established in pediatric ALL but is unclear in adult AL 2 except

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d937b0103e3ae6da0bb6ca28a8efd8f
https://doi.org/10.1158/1538-7445.am2014-564

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High Frequency Of BCR-ABL/t(22;9) Translocation As Detected By RT-PCR and Interphase FISH In Pediatric B-Cell ALL Patients Identifies The Need For Immediate Inclusion Of Tyrosine Kinase Inhibitors In Pediatric ALL Treatment Protocols

Autor: Akhtar Hussain, Ahmad Mukhtar Khalid, Noreen Sabir, Muhammad Absar, Iqbal Mudassar, Mahmood Rasool, Tashfin Awan, Tanveer Akhtar, Zafar Iqbal, Giuseppe Saglio, Aleem Aamer

Publikováno v: Blood. 122:3908-3908

Introduction Fusion oncogenes (FGs) resulted due to chromosomal abnormalities are directly responsible for leukemogenesis in pediatric B-cell acute lymphoblastic leukemia (ALL) 1. The most common FGs in pediatric B-cell ALL are BCR-ABL, MLL-AF4, ETV6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7507c7f6f0f53f6ee65b6ef9ecc5a505
https://doi.org/10.1182/blood.v122.21.3908.3908

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High frequency of BCR-ABL oncogene in pediatric acute lymphoblastic leukemia (ALL) patients as revealed by RT-PCR and interphase FISH: Association with disease biology and treatment outcome

Autor: Ammara H Tahir, Sumrin Sahar, Noreen Sabir, Tanveer Akhtar, Tashfin Awan, Zafar Iqbal, Aamer Aleem, Sultan Asad, Mohammad Hasan Siddique, Mudassar Iqbal

Publikováno v: Journal of Clinical Oncology. 30:6612-6612

6612 Background: ALL is a complex genetic disease involving many fusion oncogenes (FGs)1 frequency of which can vary in different ethnic groups2,3 thus having implication in differential diagnosis, prognosis and treatment. Methods: We studied FGs in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d86fc7333b2964b28db6371d6919790
https://doi.org/10.1200/jco.2012.30.15_suppl.6612

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Akademický článek

Detection of Five Common Fusion Oncogenes in Pakistani Children with Acute Lymphoblastic Leukemia and Their Association with Clinical Pattern and Treatment Outcome

Autor: Iqbal, Zafar ^*, Noreen, Sabir ^*, Aamer, Aleem ^*, Tashfeen, Awan ^*, Naeem, Tahir ^*, Sultan, Asad ^*, Tahir, Ammara H ^*, Absar, Muhammad ^*, Chishti, Muhammad Azhar ^*, Faiyaz-ul-Haque, Muhammad ^*, Khalid, Ahmed Mukhtar ^*, Sabar, Muhammad Farooq ^*, Rasool, Mahmood ^*, Ali, Agha Shabbir ^*, Mahmood, Amer ^*, Akram, Muhammad ^*, Saeed, Tariq ^*, Arsalan, Saleem ^*, Mohsin, Danish ^*, Shah, Ijaz Husssain ^*, Khalid, Muhammad ^*, Asif, Muhammad ^*, Iqbal, Mudassar ^*, Akhtar, Tanveer ^*

Publikováno v: In Blood 16 November 2012 120(21):5124-5124

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Akademický článek

Characterization of Common Fusion Oncogenes As Prognostic Molecular Identities in Adult Acute Lymphoblastic Leukemia Identifies the Need for Genetic Testing At Presentation, Molecular Prognostication and Differential Treatment

Autor: Iqbal, Zafar ^*, Noreen, Sabir ^*, Aamer, Aleem ^*, Tashfeen, Awan ^*, Naeem, Tahir ^*, Sultan, Asad ^*, Tahir, Ammara H ^*, Absar, Muhammad ^*, Chishti, Muhammad Azhar ^*, -ul-Haque, Muhammad Faiyaz ^*, Khalid, Ahmed Mukhtar ^*, Sabar, Muhammad Farooq ^*, Rasool, Mahmood ^*, Ali, Agha Shabbir ^*, Mahmood, Amer ^*, Akram, Muhammad ^*, Saeed, Tariq ^*, Arsalan, Saleem ^*, Mohsin, Danish ^*, Shah, Ijaz Husssain ^*, Khalid, Muhammad ^*, Asif, Muhammad ^*, Iqbal, Mudassar ^*, Akhtar, Tanveer ^*

Publikováno v: In Blood 16 November 2012 120(21):5115-5115

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