Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Noreen Naiman"'
Publikováno v:
Journal of Medicinal Chemistry. 35:4473-4478
The exceptionally good MAO-B substrate properties of several 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) derivatives have prompted studies to evaluate the corresponding properties of tetrahydropyridines bearing heteroatom-linked groups at C-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e59f340357bad605b24340e88307eda
https://doi.org/10.1021/jm00101a026
https://doi.org/10.1021/jm00101a026
Publikováno v:
Chemical Research in Toxicology. 3:133-138
Previous reports indicate that 4-benzyl-1-methyl-1,2,3,6-tetrahydropyridine (BMTP), the benzyl analogue of the Parkinsonian inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), is not neurotoxic in the C-57 black mouse even when a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456ef9a262eb3fef15585e75cbb72ff9
https://doi.org/10.1021/tx00014a008
https://doi.org/10.1021/tx00014a008
Autor:
Milt Titeler, J. L. Herndon, Richard A. Glennon, M E Pierson, Robert A. Lyon, B. Misenheimer, Noreen Naiman
Publikováno v:
Drug Development Research. 16:335-343
Arylpiperazines have been demonstrated to bind both at 5-HT1A and 5-HT1B serotonin receptors. In an attempt to design novel 5-HT1A agonists and antagonists, based on an arylpiperazine nucleus, we investigated the stimulus properties of a series of su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b2965f16c21b3441c2f5a2fbddc061c
https://doi.org/10.1002/ddr.430160227
https://doi.org/10.1002/ddr.430160227
Autor:
Abd M. Ismaiel, Noreen Naiman, Richard A. Glennon, J D Smith, Milt Titeler, Robert A. Lyon, M E Pierson
Publikováno v:
Journal of Medicinal Chemistry. 32:1921-1926
Several classes of agents are known to bind at central 5-HT1A serotonin sites In order to challenge the hypothesis that these agents bind in a relatively similar manner (i.e., share common aryl and terminal amine sites), we prepared N-(phthalimidobut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40fcc67c6102dad3bcd97bff38c55553
https://doi.org/10.1021/jm00128a039
https://doi.org/10.1021/jm00128a039
Publikováno v:
Pharmacology Biochemistry and Behavior. 26:547-551
The purpose of the present investigation was to examine the effect of N-monomethylation of phenylisopropylamine derivatives on amphetamine-like activity. In tests of stimulus generalization using rats trained to discriminate 1.0 mg/kg of (+)-amphetam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249515259d63f38c0adeef440b818fb1
https://doi.org/10.1016/0091-3057(87)90164-x
https://doi.org/10.1016/0091-3057(87)90164-x
Publikováno v:
Journal of Medicinal Chemistry. 31:1968-1971
Although simple arylpiperazines are commonly considered to be moderately selective for 5-HT1B serotonin binding sites, N4-substitution of such compounds can enhance their affinity for 5-HT1A sites and/or decrease their affinity for 5-HT1B sites. A sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b978d0dafafd275bc908880175501e9
https://doi.org/10.1021/jm00118a018
https://doi.org/10.1021/jm00118a018
Autor:
Milt Titeler, Richard A. Glennon, Ellen Weisberg, Robert A. Lyon, M. Edward Pierson, Noreen Naiman
Publikováno v:
European Journal of Pharmacology. 154:339-341
In order to determine whether NAN 190 might serve as a 5-HT 1A antagonist, it was evaluated in rats trained to discriminate 8-OH-DPAT HBr from saline in a 2-lever operant procedure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416a2ac6f23d49764e5d636e295340ee
https://doi.org/10.1016/0014-2999(88)90212-9
https://doi.org/10.1016/0014-2999(88)90212-9
Autor:
Amy E. Bullock, Richard A. Glennon, Noreen Naiman, Milt Titeler, Laura T. Rydelek, Robert A. Lyon
Publikováno v:
Journal of medicinal chemistry. 32(1)
8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) is a selective 5-HT1A serotonin agonist. Derivatives of 8-OH-DPAT with amine substituents larger or more bulky than n-propyl appear to be inactive in a presynaptic biochemical assay measuring agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234a6502bc9a0d1455d21d4e04b11921
https://pubmed.ncbi.nlm.nih.gov/2521252
https://pubmed.ncbi.nlm.nih.gov/2521252