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Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex

Autor: Roberto Cadeddu, Laura J. Mosher, Peter Nordkild, Nilesh Gaikwad, Gian Michele Ratto, Simona Scheggi, Marco Bortolato

Publikováno v: Neurobiology of Stress, Vol 21, Iss , Pp 100489- (2022)

Ample evidence indicates that environmental stress impairs information processing, yet the underlying mechanisms remain partially elusive. We showed that, in several rodent models of psychopathology, the neurosteroid allopregnanolone (AP) reduces the

Externí odkaz: https://doaj.org/article/7e1fbafd22394e87911b45dfff50ad67

Human β-Defensin 2 Mutations Are Associated With Asthma and Atopy in Children and Its Application Prevents Atopic Asthma in a Mouse Model

Autor: Natascha S. Borchers, Elisangela Santos-Valente, Antoaneta A. Toncheva, Jan Wehkamp, Andre Franke, Vincent D. Gaertner, Peter Nordkild, Jon Genuneit, Benjamin A. H. Jensen, Michael Kabesch

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Asthma and allergies are complex, chronic inflammatory diseases in which genetic and environmental factors are crucial. Protection against asthma and allergy development in the context of farming environment is established by early animal contact, un

Externí odkaz: https://doaj.org/article/ca341c6fe14e480a99d58a2818523d74

Prefrontal allopregnanolone synergizes with D 1 receptor activation to disrupt sensorimotor gating in male Sprague-Dawley rats.

Autor: Frau R; Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy. roberto.frau@unica.it.; Guy Everett Laboratory, University of Cagliari, Cagliari, Italy. roberto.frau@unica.it., Traccis F; Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy., Concas L; Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy., Cadeddu R; Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, Utah, USA., Mosher LJ; Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, Utah, USA., Nordkild P; Asarina Pharma, Copenhagen, Denmark., Gaikwad NW; Gaikwad Steroidomics, Davis, California, USA., Bortolato M; Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, Utah, USA. marco.bortolato@utah.edu.

Publikováno v: Psychopharmacology [Psychopharmacology (Berl)] 2023 Jun; Vol. 240 (6), pp. 1359-1372. Date of Electronic Publication: 2023 May 02.

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