A Direct Organocatalytic Enantioselective Route to Functionalized trans-Diels–Alder Products Having the Norcarane Scaffold

Autor: Karl Anker Jørgensen, Niklas Lawaetz Østergaard, Casper L. Barløse, Marc V. Iversen, René Slot Bitsch

Publikováno v: Barløse, C L, Østergaard, N L, Bitsch, R S, Iversen, M V & Jørgensen, K A 2021, ' A Direct Organocatalytic Enantioselective Route to Functionalized trans-Diels–Alder Products Having the Norcarane Scaffold ', Angewandte Chemie-International Edition, vol. 60, no. 33, pp. 18318-18327 . https://doi.org/10.1002/anie.202106598

An enantioselective methodology to construct trans-Diels–Alder scaffolds by organocatalysis with excellent selectivity, high yield and up to five contiguous stereocenters is presented. The reaction concept integrates the halogen effect and a novel

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https://pure.au.dk/portal/da/publications/a-direct-organocatalytic-enantioselective-route-to-functionalized-transdielsalder-products-having-the-norcarane-scaffold(1e357129-a6fc-44ca-b833-2be270153bb2).html

Synthetic Methods for the Preparation of Norcarane Scaffolds. A Review

Autor: Andrés López Radcenco, Guillermo Moyna, Florencia Parpal, Macarena Eugui

Publikováno v: Organic Preparations and Procedures International. 50:260-287

The bicyclo[4.1.0]heptane, or norcarane, fused ring system is present in a vast number of natural products, including the conifer sesquiterpenes thujopsene and hinokiic acid,1 the marasmanes isovel...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee5c53887eac4834ec3278ba8d2a34d4
https://doi.org/10.1080/00304948.2018.1462048

Use of cycloaddition reactions and photochemical transformations in the preparation of norcarane derivatives

Autor: Andrés López Radcenco, Guillermo Moyna, Carlos Tabarez

Publikováno v: Tetrahedron Letters. 57:1515-1517

We detail a strategy for the preparation of bicyclo[4.1.0]heptanes, or norcaranes, based on Diels–Alder reactions and photochemical transformations. As the latter step of the process proceeds with unique regio and stereochemistries, the regio and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f8d4611e564ee86015b4b3010145073
https://doi.org/10.1016/j.tetlet.2016.02.087

Selective hydroxylation of alkanes by an extracellular fungal peroxygenase

Autor: Matthias Kinne, René Ullrich, Gernot Kayser, Sebastian Peter, Xiaoshi Wang, Martin Hofrichter, John T. Groves

Publikováno v: FEBS Journal. 278:3667-3675

Fungal peroxygenases are novel extracellular heme-thiolate biocatalysts that are capable of catalyzing the selective monooxygenation of diverse organic compounds, using only H2O2 as a cosubstrate. Little is known about the physiological role or the c

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https://doi.org/10.1111/j.1742-4658.2011.08285.x

Profiling Mechanisms of Alkane Hydroxylase Activity In Vivo Using the Diagnostic Substrate Norcarane

Autor: Marselle Alexander-Ozinskas, Rachel N. Austin, Gerben J. Zylstra, Jong Chan Chae, Elena A. Rozhkova-Novosad, John T. Groves, Jan B. van Beilen, Luke A. Moe, Erin M. Bertrand, Michael Danahy, Dayi Deng

Publikováno v: Chemistry & Biology. 14(2):165-172

SummaryMechanistically informative chemical probes are used to characterize the activity of functional alkane hydroxylases in whole cells. Norcarane is a substrate used to reveal the lifetime of radical intermediates formed during alkane oxidation. R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf80cf32824fb18e3572ef9d0a9f877