Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Norbert Verbeke"'
Publikováno v:
In International Journal of Pharmaceutics 2002 238(1):247-256
Publikováno v:
Peptides. 25:563-569
The objective of this study was to investigate absorption enhancing approaches for systemic delivery of methionine enkephalin via the nose. Absorption promotion of methionine enkephalin in the presence of protease inhibitors (bestatin, puromycin) and
Autor:
Remigius U. Agu, Tom Willems, Renaat Kinget, Johan Van Lint, Jackie V. Vandenheede, Sandy Vandoninck, Hoang Vu Dang, Norbert Verbeke, Mark Jorissen
Publikováno v:
Pharmaceutical Research. 20:1125-1132
Purpose. The purpose of this study was to provide functional and molecular evidence to support the existence of large neutral amino acid transporters in human nasal epithelium using nasal primary cell culture model.
Publikováno v:
European Journal of Pharmaceutical Sciences. 9:213-219
Purpose: The purpose of this study was to investigate both the in vitro and in vivo release of apomorphine from mucoadhesive powder formulations of Carbopol 971P and polycarbophil. Methods: The in vitro drug release from the mucoadhesive formulations
Autor:
P. Augustijns, Mohammad Mahiuddin Talukdar, Norbert Verbeke, G. Van den Mooter, Renaat Kinget, T. Tjandra-Maga
Publikováno v:
International Journal of Pharmaceutics. 169:105-113
The controlled-release (CR) properties of xanthan gum (XG) matrix tablets were investigated in vivo. Indomethacin and the sodium salt of indomethacin were selected as model drugs to examine the properties of formulations of a very poorly soluble and
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 23:137-142
Salicylate hydroxylation using hydroxyl free radicals results into formation of 2,3-dihydroxybenzoic acid, 2,5-dihydroxybenzoic acid and catechol. Inspire of the fact that in vitro experiments have shown that catechol is a minor product, we have sho
Autor:
A. D'Hulst, S. Arens, S. Colson, Norbert Verbeke, L. Van Parijs, R. Kinget, Patrick Augustijns
Publikováno v:
Journal of Chromatographic Science. 34:276-281
A capillary electrophoretic method with low ultraviolet (185 nm) detection is presented for the analysis of both artesunate, a hemisuccinate ester analogue of artemisinin, and succinic acid without prior derivatization. Artesunate is easily separated
Autor:
Norbert Verbeke, A DHulst
Publikováno v:
Journal of Chromatography A. 735:283-293
A low-dextrose-equivalent maltodextrin was investigated for application as an enantioselective electrolyte modifier in direct chiral capillary electrophoresis. A wide range of basic racemic drug substances belonging to different pharmacological group
Autor:
Norbert Verbeke, E. Sam
Publikováno v:
Journal of Neural Transmission - Parkinson's Disease and Dementia Section. 10:115-127
The influence of R(-) apomorphine, S(+) apomorphine and dopamine on the oxidation kinetics of two polyunsaturated fatty acids (PUFA) (cholesteryl linoleate (CL) and Trilinolein (TL)) was investigated. The oxidation was initiated by free radicals gene
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 658:311-317
Dilute solutions (50 ng/ml) of apomorphine in plasma are unstable at 37 degrees C and pH 7.4. The chemical half-life is only 39 min. Mercaptoethanol (0.01%) is effective in stabilizing these samples while sodium metabisulphite (1%), which is generall