Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Norbert Schmees"'
Autor:
Rienk Offringa, Ralf Lesche, Iris Oezen, Michael Platten, Daniel Baumann, Christiane A Opitz, Ahmed Sadik, Catherine Olesch, Frederik Cichon, Norbert Schmees, Ulrike Roehn, Florian Prinz, Detlef Stoeckigt, Katharina Sahm, Nirmeen Elmadany, Christina Kober, Julian Roewe, Lars Roese, Benjamin Bader, Mátyás Gorjánácz, Helge Gottfried Roider, Gabriele Leder, Horst Irlbacher, Julien Lefranc, Mine Oezcan-Wahlbrink, Ankita Sati Batra, Rafael Carretero, Hilmar Weinmann, Ingo V Hartung, Bertolt Kreft, Ilona Gutcher
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background The metabolism of tryptophan to kynurenines (KYN) by indoleamine-2,3-dioxygenase or tryptophan-2,3-dioxygenase is a key pathway of constitutive and adaptive tumor immune resistance. The immunosuppressive effects of KYN in the tumor microen
Externí odkaz:
https://doaj.org/article/bc1e59d7b2b148a6869f255df5b9d454
Autor:
Rienk Offringa, Catherine Olesch, Frederik Cichon, Mareike Grees, Norbert Schmees, Ulrike Roehn, Florian Prinz, Detlef Stoeckigt, Michael Erkelenz, Thi Thanh Uyen Nguyen, Ulf Boemer, Judith Günther, Marc Kunze, Kirstin Petersen, Dennis Kirchhoff
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/07ab2b5c8fd7488eb234fe061e205932
Autor:
Fabian Göricke, Victoria Vu, Leanna Smith, Ulrike Scheib, Raphael Böhm, Namik Akkilic, Gerd Wohlfahrt, Jörg Weiske, Ulf Bömer, Krzysztof Brzezinka, Niels Lindner, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J. Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Norbert Schmees, Kirstin Petersen
Publikováno v:
Journal of Medicinal Chemistry. 66:3431-3447
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d87f1f7a2f8fb4f1f0646d10e1712b2
https://doi.org/10.1021/acs.jmedchem.2c01933
https://doi.org/10.1021/acs.jmedchem.2c01933
Autor:
Ingo Hartung, Masoud Vedadi, Magda Szewczyk, Volker Badock, Carlo Stresemann, Holger Steuber, Dalia Barsyte-Lovejoy, Shawna Organ, Norbert Schmees, Clara D. Christ, Detlef Stoeckigt, Steven Kennedy, Stefan Gradl, Cheryl H. Arrowsmith, Megha Abbey, Stephan Siegel, Andrea Haegebarth, Manfred Husemann, Fengling Li, Marcus Bauser, Joerg Weiske, Irene Chau, Viacheslav V. Trush, Peter Brown
Publikováno v:
SLAS Discovery. 26:947-960
SMYD3 (SET and MYND domain-containing protein 3) is a protein lysine methyltransferase that was initially described as an H3K4 methyltransferase involved in transcriptional regulation. SMYD3 has been reported to methylate and regulate several nonhist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31088aa45c9fd48a4764afae98765927
https://doi.org/10.1177/24725552211019409
https://doi.org/10.1177/24725552211019409
Autor:
Eckhard Bender, Olaf Prien, Reinhard Nubbemeyer, Stefan Bäurle, Norbert Schmees, Wilhelm Bone, Andreas Steinmeyer, Gernot Langer, Olaf Panknin, Thomas Mueller, Thomas M. Zollner, Katrin Nowak-Reppel, Martina Schäfer, Andrea Wagenfeld, Sven Ring, Amaury Ernesto Fernandez-Montalvan, Christian Friedrich
Publikováno v:
Journal of medicinal chemistry. 63(20)
The growth of uterine fibroids is sex hormone-dependent and commonly associated with highly incapacitating symptoms. Most treatment options consist of the control of these hormonal effects, ultimately blocking proliferative estrogen signaling (i.e.,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426db565493e565bf916243aff255067
https://pubmed.ncbi.nlm.nih.gov/32960053
https://pubmed.ncbi.nlm.nih.gov/32960053
Autor:
Filippo Spriano, Chiara Tarantelli, Ivo Kwee, Eugenio Gaudio, Stephan Siegel, Afua Adjeiwaa Mensah, Emanuele Zucca, Francesco Bertoni, Pascale Lejeune, Norbert Schmees, Andrea Rinaldi, Elena Bernasconi, Elaine Chung, Anastasios Stathis, Matthias Ocker, Bernard Haendler, Luciano Cascione
Publikováno v:
British journal of haematology. 178(6)
Summary The epigenome is often deregulated in cancer and treatment with inhibitors of bromodomain and extra-terminal proteins, the readers of epigenetic acetylation marks, represents a novel therapeutic approach. Here, we have characterized the anti-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1644414a587b2b12897450b22e00b138
https://pubmed.ncbi.nlm.nih.gov/28653353
https://pubmed.ncbi.nlm.nih.gov/28653353
Autor:
Benjamin Bader, Ilona Gutcher, Ludiwg Zorn, Lars Roese, Hilmar Weinmann, Christina Kober, Michael Platten, Ulrike Roehn, Bertolt Kreft, Iris Oezen, Horst Irlbacher, Detlef Stoeckigt, Rafael Carretero, Norbert Schmees, Ingo Hartung
Publikováno v:
Cancer Research. 79:4454-4454
Re-constitution of anti-tumor T-cell responses by clinically-approved immune checkpoint inhibitors (ICIs) targeting CTLA4 or PD-1/PD-L1 represents a breakthrough cancer therapy. Nevertheless, a substantial number of patients do not benefit from these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b5018e1ced8aa35387f8677f5fb5b87
https://doi.org/10.1158/1538-7445.am2019-4454
https://doi.org/10.1158/1538-7445.am2019-4454
Autor:
Julian Roewe, Horst Irlbacher, Florian Prinz, Mátyás Gorjánácz, Lars Roese, Ulrike Roehn, Bertolt Kreft, Norbert Schmees, Katharina Sahm, Michael Platten, Benjamin Bader, Hilmar Weinmann, Christina Kober, Rafael Carretero, Ingo Hartung, Iris Oezen, Ilona Gutcher, Detlef Stoeckigt
Publikováno v:
Cancer Research. 79:1288-1288
Tumor cells co-opt multiple pathways in order to evade attack by infiltrating immune cells. One such mechanism is the upregulation of indole-2,3-dioxygenase (IDO1) and/or tryptophan-2,3-dioxygenase (TDO2), both of which are first-step, rate-limiting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eb4fa5d5c5885eaf1f788ce23b46a4b
https://doi.org/10.1158/1538-7445.am2019-1288
https://doi.org/10.1158/1538-7445.am2019-1288
Autor:
Lisa Wissler, Stefan Jaroch, Norbert Schmees, Andreas Reichel, Heike Schäcke, Hartmut Rehwinkel, Markus Berger, Karl Edman
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(3)
We report on the discovery of two new lead series for the development of glucocorticoid receptor agonists. Firstly, the discovery of tetrahydronaphthalenes led to metabolically stable and dissociated compounds. Their binding mode to the glucocorticoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d376ae470ffd5041091493be2417d76a
https://pubmed.ncbi.nlm.nih.gov/28043796
https://pubmed.ncbi.nlm.nih.gov/28043796
Autor:
Manfred Husemann, Fengling Li, Volker Badock, Viacheslav V. Trush, Detlef Stoeckigt, Cheryl H. Arrowsmith, Jörg Weiske, Shawna Organ, Stephan Siegel, Stefan Gradl, Amaury Ernesto Fernandez-Montalvan, Norbert Schmees, Magdalena M. Szewczyk, Holger Steuber, Masoud Vedadi, Steven Kennedy, Clara D. Christ, Marcus Bauser, Dalia Barsyte-Lovejoy, Andrea Haegebarth, Ingo Hartung, Carlo Stresemann, Peter Brown
Publikováno v:
Cancer Research. 78:1646-1646
SMYD3 (SET and MYND domain-containing protein 3) is a protein lysine methyltransferase (PKMT) which was initially described as H3K4 methyltransferase involved in transcriptional regulation. SMYD3 has recently been reported to methylate and regulate s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51143612007dd573d01cbe81426aa209
https://doi.org/10.1158/1538-7445.am2018-1646
https://doi.org/10.1158/1538-7445.am2018-1646