Zobrazeno 1 - 10 of 69 pro vyhledávání: '"Norbert Schaschke"'
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Treatment of rat thyrocytes in vitro with cathepsin B and L inhibitors results in disruption of primary cilia leading to redistribution of the trace amine associated receptor 1 to the endoplasmic reticulum
Autor: Klaudia Brix, Matthew Bogyo, Joanna Szumska, Norbert Schaschke, Vladislav Skripnik, Alaa Al-Hashimi, Vaishnavi Venugopalan, Zaina Batool
Publikováno v: Biochimie. 166
Taar1 is a G protein-coupled receptor (GPCR) confined to primary cilia of rodent thyroid epithelial cells. Taar1-deficient mouse thyroid follicles feature luminal accumulation of thyroglobulin suggesting that Taar1 acts as a regulator of extra- and p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546011595e80580e3adc0ebcc58fb97a
https://pubmed.ncbi.nlm.nih.gov/31302164
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9
Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis
Autor: Daniel S. John, Matthias Sendler, Julia Mayerle, Markus M. Lerch, F. Ulrich Weiss, Sandrina Maertin, Walter Halangk, Maria Persike, Preshit R. Wagh, Thomas Wartmann, Norbert Schaschke, Burkhard Krüger
Publikováno v: Journal of Biological Chemistry. 291:14717-14731
Pancreatitis is associated with premature activation of digestive proteases in the pancreas. The lysosomal hydrolase cathepsin B (CTSB) is a known activator of trypsinogen, and its deletion reduces disease severity in experimental pancreatitis. Here
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826ac90a5da156c61e6958daaa449ccf
https://doi.org/10.1074/jbc.m116.718999
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Plný text Recenzováno Digitální knihovna AV ČR
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