Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Norbert Moldovan"'
Autor:
Birgit M. M. Wever, Mirte Schaafsma, Maaike C. G. Bleeker, Yara van den Burgt, Rianne van den Helder, Christianne A. R. Lok, Frederike Dijk, Ymke van der Pol, Florent Mouliere, Norbert Moldovan, Nienke E. van Trommel, Renske D. M. Steenbergen
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-9 (2024)
Abstract Background High ovarian cancer mortality rates motivate the development of effective and patient-friendly diagnostics. Here, we explored the potential of molecular testing in patient-friendly samples for ovarian cancer detection. Methods Hom
Externí odkaz:
https://doaj.org/article/b37f463903654b47a5643f0aee14b3e7
Autor:
Norbert Moldovan, Sandra Verkuijlen, Ymke van der Pol, Leontien Bosch, Jan R.T. van Weering, Idris Bahce, D. Michiel Pegtel, Florent Mouliere
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110742- (2024)
Summary: Blood contains multiple analytes that can be used as liquid biopsy to analyze cancer. Mutations have been detected in DNA associated with small extracellular vesicles (sEVs). The genome-wide composition and structure of sEV DNA remains poorl
Externí odkaz:
https://doaj.org/article/5f34ee0e26cb412d835d0c29a2af68ee
Autor:
Ymke van der Pol, Norbert Moldovan, Jip Ramaker, Sanne Bootsma, Kristiaan J. Lenos, Louis Vermeulen, Shahneen Sandhu, Idris Bahce, D. Michiel Pegtel, Stephen Q. Wong, Sarah-Jane Dawson, Dineika Chandrananda, Florent Mouliere
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Existing methods to detect tumor signal in liquid biopsy have focused on the analysis of nuclear cell-free DNA (cfDNA). However, non-nuclear cfDNA and in particular mitochondrial DNA (mtDNA) has been understudied. We hypothesize t
Externí odkaz:
https://doaj.org/article/f391dac559774ebc9fe41ed580f121ff
Autor:
Ymke van derPol, Normastuti Adhini Tantyo, Nils Evander, Anouk E Hentschel, Birgit MM Wever, Jip Ramaker, Sanne Bootsma, Marieke F Fransen, Kristiaan J Lenos, Louis Vermeulen, Famke L Schneiders, Idris Bahce, Jakko A Nieuwenhuijzen, Renske DM Steenbergen, D Michiel Pegtel, Norbert Moldovan, Florent Mouliere
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp n/a-n/a (2023)
Abstract Cell‐free DNA (cfDNA) can be isolated and sequenced from blood and/or urine of cancer patients. Conventional short‐read sequencing lacks deployability and speed and can be biased for short cfDNA fragments. Here, we demonstrate that with
Externí odkaz:
https://doaj.org/article/b680ea20f07b4e7887161c9b62d150f1
Autor:
Ymke van der Pol, Steven Wang, Norbert Moldovan, A.Vera de Jonge, Esther E.E. Drees, Margaretha Roemer, Bauke Ylstra, Marcel Nijland, Marjolein W.M. Van Der Poel, Koen de Heer, Clara Klerk, Rozemarijn van Rijn, Rob Fijnheer, Vibeke K.J. Vergote, Aart Beeker, Laurens Nieuwenhuizen, Rogier Mous, Joost S.P. Vermaat, D. Michiel Pegtel, Martine E.D. Chamuleau, Florent Mouliere
Publikováno v:
Blood. 140:3529-3531
Autor:
Ymke van der Pol, Normastuti Adhini Tantyo, Nils Evander, Anouk E. Hentschel, Jip Ramaker, Idris Bahce, Jakko A. Nieuwenhuijzen, Renske D.M. Steenbergen, D. Michiel Pegtel, Norbert Moldovan, Florent Mouliere
Cell-free DNA (cfDNA) can be isolated from blood and/or urine of cancer patients and analyzed with sequencing. Unfortunately, most conventional short-read sequencing methods are technically challenging, labor intensive and time consuming, requiring s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::565f438f1953a910c9a0b03dd84064f3
https://doi.org/10.1101/2022.08.11.22278674
https://doi.org/10.1101/2022.08.11.22278674
Autor:
Norbert Moldovan, Sandra Verkuijlen, Ymke van der Pol, Leontien Bosch, Jan R.T. van Weering, Idris Bahce, D. Michiel Pegtel, Florent Mouliere
Liquid biopsies contain multiple analytes that can be mined to improve the detection and management of cancer. Beyond cell-free DNA (cfDNA), mutations have been detected in DNA associated with extracellular vesicles (EV-DNA). The genome-wide composit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06faf938a77ec1860b461cc8b9fb3993
https://doi.org/10.1101/2022.07.22.501161
https://doi.org/10.1101/2022.07.22.501161
Autor:
Ymke van der Pol, Norbert Moldovan, Sandra Verkuijlen, Jip Ramaker, Dries Boers, Wendy Onstenk, Johan de Rooij, Idris Bahce, D Michiel Pegtel, Florent Mouliere
Publikováno v:
van der Pol, Y, Moldovan, N, Verkuijlen, S, Ramaker, J, Boers, D, Onstenk, W, de Rooij, J, Bahce, I, Pegtel, D M & Mouliere, F 2022, ' The Effect of Preanalytical and Physiological Variables on Cell-Free DNA Fragmentation ', Clinical Chemistry, vol. 68, no. 6, pp. 803-813 . https://doi.org/10.1093/clinchem/hvac029
Clinical Chemistry, 68(6), 803-813
Clinical Chemistry, 68(6), 803-813
BackgroundAssays that account for the biological properties and fragmentation of cell-free DNA (cfDNA) can improve the performance of liquid biopsy. However, preanalytic and physiological differences between individuals on fragmentomic analysis are p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32ce0551ecead9265eb222612986c06
https://research.vumc.nl/en/publications/6586d772-4522-4a1d-af1d-7028808e23db
https://research.vumc.nl/en/publications/6586d772-4522-4a1d-af1d-7028808e23db
Autor:
Tom van den Ende, Steven C. Kuijper, Yousif Widaatalla, Wyanne A. Noortman, Floris H.P. van Velden, Henry C. Woodruff, Ymke van der Pol, Norbert Moldovan, D. Michiel Pegtel, Sarah Derks, Maarten F. Bijlsma, Florent Moulière, Lioe-Fee de Geus-Oei, Philippe Lambin, Hanneke W.M. Van Laarhoven
Publikováno v:
Journal of Clinical Oncology. 41:423-423
423 Background: Despite the advent of precision medicine, prediction of survival outcome of esophageal cancer patients remains a challenge. Here we aim to investigate the value of prediction models integrating multi-signal data including radiomics an
Autor:
Ymke van der Pol, Norbert Moldovan, Sandra Verkuijlen, Jip Ramaker, Dries Boers, Wendy Onstenk, Johan de Rooij, Idris Bahce, D. Michiel Pegtel, Florent Mouliere
Assays that account for the biological properties and fragmentation of cell-free DNA (cfDNA) can improve the performance of liquid biopsy. However, pre-analytic and physiological differences between individuals on fragmentomic analysis are poorly def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7dcd3509f0c009e1207ea5eb7e31d44
https://doi.org/10.1101/2021.09.17.460828
https://doi.org/10.1101/2021.09.17.460828