Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Norbert Krug"'
Autor:
Valentyna Yasinska, Cristina Gómez, Johan Kolmert, Magnus Ericsson, Anton Pohanka, Anna James, Lars I. Andersson, Maria Sparreman-Mikus, Ana R. Sousa, John H. Riley, Stewart Bates, Per S. Bakke, Nazanin Zounemat Kermani, Massimo Caruso, Pascal Chanez, Stephen J. Fowler, Thomas Geiser, Peter H. Howarth, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Annelie Behndig, Dominick E. Shaw, Richard G. Knowles, Barbro Dahlén, Anke-Hilse Maitland-van der Zee, Peter J. Sterk, Ratko Djukanovic, Ian M. Adcock, Kian Fan Chung, Craig E. Wheelock, Sven-Erik Dahlén, Eva Wikström Jonsson, H. Ahmed
Publikováno v:
ERJ Open Research, Vol 9, Iss 5 (2023)
Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) suppression in asthma has not p
Externí odkaz:
https://doaj.org/article/a7fc69aad4384962865d87d94aff46ed
Autor:
Uruj Hoda, Stelios Pavlidis, Aruna T. Bansal, Kentaro Takahashi, Sile Hu, Francois Ng Kee Kwong, Christos Rossios, Kai Sun, Pankaj Bhavsar, Matthew Loza, Frederic Baribaud, Pascal Chanez, Stephen J. Fowler, Ildiko Horvath, Paolo Montuschi, Florian Singer, Jacek Musial, Barbro Dahlen, Norbert Krug, Thomas Sandstrom, Dominic E. Shaw, Rene Lutter, Louise J. Fleming, Peter H. Howarth, Massimo Caruso, Ana R. Sousa, Julie Corfield, Charles Auffray, Bertrand De Meulder, Diane Lefaudeux, Sven‐Erik Dahlen, Ratko Djukanovic, Peter J. Sterk, Yike Guo, Ian M. Adcock, Kian Fan Chung, the U‐BIOPRED study group
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 4, Pp n/a-n/a (2022)
Abstract Background Exacerbation‐prone asthma is a feature of severe disease. However, the basis for its persistency remains unclear. Objectives To determine the clinical and transcriptomic features of frequent exacerbators (FEs) and persistent FEs
Externí odkaz:
https://doaj.org/article/472cffbdc9ba4c16ac2d4d6cd89330da
Autor:
Vlad A Bratu, Veit J Erpenbeck, Antonia Fehrenbach, Tanja Rausch, Susanne Rittinghausen, Norbert Krug, Jens M Hohlfeld, Heinz Fehrenbach
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92510 (2014)
QUESTION: Inflammatory cell numbers are important endpoints in clinical studies relying on endobronchial biopsies. Assumption-based bidimensional (2D) counting methods are widely used, although theoretically design-based stereologic three-dimensional
Externí odkaz:
https://doaj.org/article/15fa48ef16694a089cacc1af155b50e2
Autor:
Stefan Röpcke, Olaf Holz, Gereon Lauer, Meike Müller, Susanne Rittinghausen, Peter Ernst, Gezim Lahu, Martin Elmlinger, Norbert Krug, Jens M Hohlfeld
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46207 (2012)
Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory disease, primarily affecting the airways. Stable biomarkers characterizing the inflammatory phenotype of the disease, relevant for disease activity and suited to predict disease p
Externí odkaz:
https://doaj.org/article/08ee681f45314d08b95fa3da8fa61590
Autor:
Jens Tank, Heike Biller, Karsten Heusser, Olaf Holz, André Diedrich, Theodor Framke, Armin Koch, Anika Grosshennig, Wolfgang Koch, Norbert Krug, Jens Jordan, Jens M Hohlfeld
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18737 (2011)
BACKGROUND: Ozone concentrations in ambient air are related to cardiopulmonary perturbations in the aging population. Increased central sympathetic nerve activity induced by local airway inflammation may be one possible mechanism. METHODOLOGY/PRINCIP
Externí odkaz:
https://doaj.org/article/a488879650cb42de85ce50a62152161e
Autor:
P. J. Sterk, John H. Riley, Thomas Sandström, Anna Selby, Laurie Pahus, C. Auffray, Ioannis Pandis, Julie Corfield, R. Djukanovic, K. Sun, Massimo Caruso, Jørgen Vestbo, Matthew J. Loza, Andrew J. Simpson, Dominic Burg, I.M. Adcock, S. Bates, Scott Wagers, Ana R. Sousa, J. Corfield, Ariane H. Wagener, René Lutter, Barbro Dahlén, Ratko Djukanovic, G. Praticò, I. Pandis, N. Mores, G. Hedlin, Navin Rao, I. Horváth, Alexander Mazein, B. De Meulder, Richard G. Knowles, John-Olof Thörngren, Wolfgang Seibold, P H Howarth, Victoria M. Goss, Cristina Gómez, Clare S. Murray, Paul Brinkman, Ildiko Horvath, Anthony D. Postle, M. Caruso, Martina Gahlemann, M. Puig Valls, F.K. Chung, P. Montuschi, Dominick E. Shaw, Kai Sun, Aruna T. Bansal, Fahad Alahmadi, Amphun Chaiboonchoe, Graham Roberts, Kian Fan Chung, Yike Guo, H. Ahmed, Thomas Geiser, Klaus Bønnelykke, M. Miralpeix, Simone Hashimoto, Diane Lefaudeux, S.S. Wagers, D. Erzen, B. Thornton, Florian Singer, Louise Fleming, Stephen J. Fowler, Neil Fitch, P. Bakke, Craig E. Wheelock, Nadja Hawwa Vissing, Tim Higenbottam, Jamie Matthews, F. Singer, S.E. Dahlén, Sarah Masefield, Roelinde Middelveld, Jens M. Hohlfeld, Anthony V. D'Amico, Paul Skipp, W.M.C. van Aalderen, Alan J. Knox, Sven-Erik Dahlén, Andrew Bush, A.T. Bansal, Pieter-Paul Hekking, Joost Brandsma, Stewart Bates, L.J. Fleming, Norbert Krug, N. Krug, Magnus Ericsson, J. Riley, P. Powel, Jacek Musiał, Amanda Roberts, Peter J. Sterk, Ian M. Adcock, Pascal Chanez, Cecile T.J. Holweg, F. Baribaud, Stelios Pavlidis, Veit J. Erpenbeck, Z. Weiszhart, C.E. Wheelock, Ralf Sigmund, James P.R. Schofield, Alexander Manta, Andrea Meiser, Susan J. Wilson, Jeanette Bigler, G. Roberts, M. van Geest, Hans Bisgaard, Urs Frey, Michael Boedigheimer, Per Bakke, Chris Compton, Enrica Bucchioni, Paolo Montuschi, David Myles, E.H.D. Bel, Anna James, Elena Formaggio, Anthony Rowe, Dominic E. Shaw, J. Haughney, P. Chanez, A.R. Sousa, S.J. Fowler, K. Fichtner, B. Dahlèn
Publikováno v:
U-BIOPRED Study Group 2021, ' Medication adherence in patients with severe asthma prescribed oral corticosteroids in the U-BIOPRED cohort ', Chest . https://doi.org/10.1016/j.chest.2021.02.023
Alahmadi, Fahad H; Simpson, Andrew J; Gomez, Cristina; Ericsson, Magnus; Thörngren, John-Olof; Wheelock, Craig; Shaw, Dominic E; Fleming, Louise J; Roberts, Graham; Riley, John; Bates, Stewart; Sousa, Ana R; Knowles, Richard; Bansal, Aruna T; Corfield, Julie; Pandis, Ioannis; Sun, Kai; Bakke, Per S; Caruso, Massimo; Chanez, Pascal; ... (2021). Medication Adherence in Patients With Severe Asthma Prescribed Oral Corticosteroids in the U-BIOPRED Cohort. Chest, 160(1), pp. 53-64. Elsevier 10.1016/j.chest.2021.02.023
Chest
Chest, 2021, 160 (1), pp.53-64. ⟨10.1016/j.chest.2021.02.023⟩
Chest, 160(1), 53-64. American College of Chest Physicians
Alahmadi, Fahad H; Simpson, Andrew J; Gomez, Cristina; Ericsson, Magnus; Thörngren, John-Olof; Wheelock, Craig; Shaw, Dominic E; Fleming, Louise J; Roberts, Graham; Riley, John; Bates, Stewart; Sousa, Ana R; Knowles, Richard; Bansal, Aruna T; Corfield, Julie; Pandis, Ioannis; Sun, Kai; Bakke, Per S; Caruso, Massimo; Chanez, Pascal; ... (2021). Medication Adherence in Patients With Severe Asthma Prescribed Oral Corticosteroids in the U-BIOPRED Cohort. Chest, 160(1), pp. 53-64. Elsevier 10.1016/j.chest.2021.02.023
Chest
Chest, 2021, 160 (1), pp.53-64. ⟨10.1016/j.chest.2021.02.023⟩
Chest, 160(1), 53-64. American College of Chest Physicians
Background: Although estimates of suboptimal adherence to oral corticosteroids in asthma range from 30% to 50%, no ideal method for measurement exists; the impact of poor adherence in severe asthma is likely to be particularly high. Research Question
Autor:
Norbert Krug, Tibor Z. Veres, Armin Braun, Thomas Tschernig, Susanne Rittinghausen, Katherina Sewald, Frauke Prenzler, Jens M. Hohlfeld
Publikováno v:
Allergy. 76:2907-2910
Autor:
Ana B. Pavel, Norbert Krug, Dominick E. Shaw, Florian Singer, Peter H. Howarth, Stewart Bates, SE Dahlen, Louise Fleming, Johan Kolmert, Kian Fan Chung, Nazanin Zounemat Kermani, John H. Riley, Stephen J. Fowler, Craig E. Wheelock, Yusef Badi, Stelios Pavlidis, Massimo Caruso, Yike Guo, Anke H. Maitland-van der Zee, Kjell Alving, Ildiko Horvath, Peter J. Sterk, Ian M. Adcock, Pascal Chanez, Sally Worsley, Marek Sanak, Ratko Djukanovic, Per Bakke, Paolo Montuschi, Emma Guttman-Yassky, Richard G. Knowles, Urs Frey, Annelie F. Behndig, Mohib Uddin, Graham T. Roberts
Publikováno v:
Journal of allergy and clinical immunology, 149(1), 89-101. Mosby Inc.
Badi, Yusef Eamon; Pavel, Ana B; Pavlidis, Stelios; Riley, John H; Bates, Stewart; Kermani, Nazanin Zounemat; Knowles, Richard; Kolmert, Johan; Wheelock, Craig E; Worsley, Sally; Uddin, Mohib; Alving, Kjell; Bakke, Per S; Behndig, Annelie; Caruso, Massimo; Chanez, Pascal; Fleming, Louise J; Fowler, Stephen J; Frey, Urs; Howarth, Peter; ... (2022). Mapping atopic dermatitis and anti-IL-22 response signatures to Type 2-low severe neutrophilic asthma. Journal of allergy and clinical immunology, 149(1), pp. 89-101. Elsevier 10.1016/j.jaci.2021.04.010
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, 2022, 149 (1), pp.89-101. ⟨10.1016/j.jaci.2021.04.010⟩
U-BIOPRED Study Group 2021, ' Mapping atopic dermatitis and anti-IL-22 response signatures to type 2-low severe neutrophilic asthma ', The Journal of allergy and clinical immunology . https://doi.org/10.1016/j.jaci.2021.04.010
Badi, Yusef Eamon; Pavel, Ana B; Pavlidis, Stelios; Riley, John H; Bates, Stewart; Kermani, Nazanin Zounemat; Knowles, Richard; Kolmert, Johan; Wheelock, Craig E; Worsley, Sally; Uddin, Mohib; Alving, Kjell; Bakke, Per S; Behndig, Annelie; Caruso, Massimo; Chanez, Pascal; Fleming, Louise J; Fowler, Stephen J; Frey, Urs; Howarth, Peter; ... (2022). Mapping atopic dermatitis and anti-IL-22 response signatures to Type 2-low severe neutrophilic asthma. Journal of allergy and clinical immunology, 149(1), pp. 89-101. Elsevier 10.1016/j.jaci.2021.04.010
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, 2022, 149 (1), pp.89-101. ⟨10.1016/j.jaci.2021.04.010⟩
U-BIOPRED Study Group 2021, ' Mapping atopic dermatitis and anti-IL-22 response signatures to type 2-low severe neutrophilic asthma ', The Journal of allergy and clinical immunology . https://doi.org/10.1016/j.jaci.2021.04.010
Background: Transcriptomic changes in patients who respond clinically to biological therapies may identify responses in other tissues or diseases. Objective: We sought to determine whether a disease signature identified in atopic dermatitis (AD) is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6225f583d12c38900493ddc19f22a0f
https://pure.amc.nl/en/publications/mapping-atopic-dermatitis-and-antiil22-response-signatures-to-type-2low-severe-neutrophilic-asthma(2ad79baf-37e4-4dc7-9c5b-d6d4cd3eab27).html
https://pure.amc.nl/en/publications/mapping-atopic-dermatitis-and-antiil22-response-signatures-to-type-2low-severe-neutrophilic-asthma(2ad79baf-37e4-4dc7-9c5b-d6d4cd3eab27).html
Autor:
Angelica Tiotiu, Yusef Badi, Nazanin Zounemat Kermani, Marek Sanak, Johan Kolmert, Craig E. Wheelock, Philip M. Hansbro, Sven-Erik Dahlén, Peter J. Sterk, Ratko Djukanovic, Yike Guo, Sharon Mumby, Ian M. Adcock, Kian Fan Chung, Uruj Hoda, Christos Rossios, Elisabeth Bel, Navin Rao, David Myles, Chris Compton, Marleen Van Geest, Peter Howarth, Graham Roberts, Diane Lefaudeux, Bertrand De Meulder, Aruna T. Bansal, Richard Knowles, Damijn Erzen, Scott Wagers, Norbert Krug, Tim Higenbottam, John Matthews, Veit Erpenbeek, Leon Carayannopoulos, Amanda Roberts, David Supple, Pim deBoer, Massimo Caruso, Pascal Chanez, Ildikó Horváth, Jacek Musial, Thomas Sandström
Publikováno v:
U-BIOPRED Consortium Project Team 2022, ' Association of Differential Mast Cell Activation with Granulocytic Inflammation in Severe Asthma ', American Journal of Respiratory and Critical Care Medicine, vol. 205, no. 4, pp. 397-411 . https://doi.org/10.1164/rccm.202102-0355OC
American journal of respiratory and critical care medicine, 205(4), 397-411. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine, 205(4), 397-411. American Thoracic Society
American journal of respiratory and critical care medicine, 205(4), 397-411. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine, 205(4), 397-411. American Thoracic Society
Rationale: Mast cells (MCs) play a role in inflammation and both innate and adaptive immunity, but their involvement in severe asthma (SA) remains undefined. Objectives: We investigated the phenotypic characteristics of the U-BIOPRED (Unbiased Biomar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0769f3396c2d0e280947dd7c7b135cf2
https://ruj.uj.edu.pl/xmlui/handle/item/290001
https://ruj.uj.edu.pl/xmlui/handle/item/290001
Autor:
Peter J. Sterk, Nazanin Zounemat Kermani, Ian M. Adcock, Pascal Chanez, Florian Singer, Stewart Bates, Magnus Ericsson, John H. Riley, Jessica Lasky-Su, Romanas Chaleckis, Ildiko Horvath, Hector Gallart-Ayala, Stephen J. Fowler, Craig E. Wheelock, Norbert Krug, Henric Olsson, Stacey N. Reinke, Jacek Musiał, Peter H. Howarth, Matthew J. Loza, Kian Fan Chung, Barbro Dahlén, Thomas Geiser, Massimo Caruso, David I. Broadhurst, Cristina Gómez, Dominick E. Shaw, Johan Kolmert, Per Bakke, Angelica Tiotiu, Paolo Montuschi, Sile Hu, Ratko Djukanovic, Ana R. Sousa, Sven-Erik Dahlén, Frédéric Baribaud, James Scholfield, Shama Naz, Åsa M. Wheelock, Anders Lundqvist, Annelie F. Behndig, Marika Ström
Publikováno v:
European Respiratory Journal
Reinke, Stacey N; Naz, Shama; Chaleckis, Romanas; Gallart-Ayala, Hector; Kolmert, Johan; Kermani, Nazanin Z; Tiotiu, Angelica; Broadhurst, David I; Lundqvist, Anders; Olsson, Henric; Ström, Marika; Wheelock, Åsa M; Gómez, Cristina; Ericsson, Magnus; Sousa, Ana R; Riley, John H; Bates, Stewart; Scholfield, James; Loza, Matthew; Baribaud, Frédéric; ... (2022). Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study. European respiratory journal, 59(6) European Respiratory Society 10.1183/13993003.01733-2021
Reinke, S N, Naz, S, Chaleckis, R, Gallart-Ayala, H, Kolmert, J, Kermani, N Z, Tiotiu, A, Broadhurst, D I, Lundqvist, A, Olsson, H, Ström, M, Wheelock, Å M, Gómez, C, Ericsson, M, Sousa, A R, Riley, J H, Bates, S, Scholfield, J, Loza, M, Baribaud, F, Bakke, P S, Caruso, M, Chanez, P, Fowler, S J, Geiser, T, Howarth, P, Horváth, I, Krug, N, Montuschi, P, Behndig, A, Singer, F, Musial, J, Shaw, D E, Dahlén, B, Hu, S, Lasky-Su, J, Sterk, P J, Chung, K F, Djukanovic, R, Dahlén, S-E, Adcock, I M & Wheelock, C E 2021, ' Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study ', The European respiratory journal . https://doi.org/10.1183/13993003.01733-2021
European respiratory journal, 59(6):01733. European Respiratory Society
European Respiratory Journal, 2021, pp.2101733. ⟨10.1183/13993003.01733-2021⟩
Reinke, Stacey N; Naz, Shama; Chaleckis, Romanas; Gallart-Ayala, Hector; Kolmert, Johan; Kermani, Nazanin Z; Tiotiu, Angelica; Broadhurst, David I; Lundqvist, Anders; Olsson, Henric; Ström, Marika; Wheelock, Åsa M; Gómez, Cristina; Ericsson, Magnus; Sousa, Ana R; Riley, John H; Bates, Stewart; Scholfield, James; Loza, Matthew; Baribaud, Frédéric; ... (2022). Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study. European respiratory journal, 59(6) European Respiratory Society 10.1183/13993003.01733-2021
Reinke, S N, Naz, S, Chaleckis, R, Gallart-Ayala, H, Kolmert, J, Kermani, N Z, Tiotiu, A, Broadhurst, D I, Lundqvist, A, Olsson, H, Ström, M, Wheelock, Å M, Gómez, C, Ericsson, M, Sousa, A R, Riley, J H, Bates, S, Scholfield, J, Loza, M, Baribaud, F, Bakke, P S, Caruso, M, Chanez, P, Fowler, S J, Geiser, T, Howarth, P, Horváth, I, Krug, N, Montuschi, P, Behndig, A, Singer, F, Musial, J, Shaw, D E, Dahlén, B, Hu, S, Lasky-Su, J, Sterk, P J, Chung, K F, Djukanovic, R, Dahlén, S-E, Adcock, I M & Wheelock, C E 2021, ' Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study ', The European respiratory journal . https://doi.org/10.1183/13993003.01733-2021
European respiratory journal, 59(6):01733. European Respiratory Society
European Respiratory Journal, 2021, pp.2101733. ⟨10.1183/13993003.01733-2021⟩
IntroductionAsthma is a heterogeneous disease with poorly defined phenotypes. Patients with severe asthma often receive multiple treatments including oral corticosteroids (OCS). Treatment may modify the observed metabotype, rendering it challenging t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e44649ee35b8f7c945ee381b8be1f1
https://hdl.handle.net/11250/3025378
https://hdl.handle.net/11250/3025378