Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Norbert Knebel"'
Publikováno v:
Archiv der Pharmazie. 324:779-784
Durch Umsetzung von K2P1CI4 mit den 2-Aminomethylpyridinliganden 9, 14 und 22 sind die entspr. Dichloroplatin(II)-Komplexe 3-5 erhaltlich. Die Verbindungen 3 und 22 zeigen beachtliche Bindungsaffinitaten zum Estrogenrezeptor. Gegen den hormonunabhang
Autor:
Carl Johan Sennbro, Sirpa Laakso, Dietmar Schmidt, Josep Maria Jansat, Achim Freisleben, Hans Mulder, Marcel de Zwart, Pierre Boulanger, Michael P. Andersen, Elizabeth Thomas, Stephanie Fischmann, Nathalie Mokrzycki-Issartel, Dirk Kasel, Morten A. Kall, Philip Timmerman, Richard Hucker, Fernando Romero, Stephen White, Berthold Lausecker, Susanne Globig, Silke Luedtke, Ben Gordon, Norbert Knebel, Peter van Amsterdam, Magnus Knutsson, Richard Abbott, Margarete Brudny-Kloeppel
Publikováno v:
Bioanalysis. 1:1049-1056
Following intensive discussions, review, alignment of procedures and multiple surveys among their member companies, the European Bioanalysis Forum (EBF) is providing a recommendation on how to integrate incurred sample reproducibility (ISR) in the bi
Autor:
Michael Zschiesche, Norbert Knebel, Jack Bergman, Godfrey H. Redhi, Christine Tober, Carol A. Paronis, Sevil Yasar, Patrik Munzar
Publikováno v:
European Journal of Pharmacology. 465:257-265
AWD 131-138 [1-(4-chlorophenyl)-4-morpholino-imidazolin-2-one], a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models, was studied in squirrel monkeys trained to discriminate
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
A high throughput bioanalytical method based on semi-automated liquid extraction and liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed for the sensitive quantification of roflumilast and its metabolite roflumilast N-oxide,
Publikováno v:
ChemInform. 22
A number of 1-(omega-aminoalkyl)-5-hydroxy-2-(4-hydroxyphenyl)indoles were synthesized and studied for their binding affinities for the calf uterine estrogen receptor and estrogen antagonistic activities. Highest binding affinities were found with de
Publikováno v:
Xenobiotica. 22:1157-1164
1. (R)-(+)-Pulegone is a monoterpene that is oxidized by cytochromes P-450 to reactive metabolites that initiate events in the pathogenesis of hepatotoxicity in mice, rats and humans. 2. Selective labelling of (R)-(+)-pulegone with deuterium revealed
Publikováno v:
Chemical Research in Toxicology. 5:123-130
Menthofuran, a naturally occurring hepatotoxin, is metabolically activated to chemically reactive intermediates that are capable of covalent binding to cellular proteins. Studies in vivo and in vitro with inhibitors and inducers of hepatic cytochrome
Publikováno v:
Journal of Medicinal Chemistry. 33:2635-2640
A number of 1-(omega-aminoalkyl)-5-hydroxy-2-(4-hydroxyphenyl)indoles were synthesized and studied for their binding affinities for the calf uterine estrogen receptor and estrogen antagonistic activities. Highest binding affinities were found with de
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 793(2)
Enantioselective separation methods and the enantioselective determination of the anti-allergic drug azelastine and of three of its main phase I metabolites in a biological matrix underwent chromatographic and electrophoretic investigations. An enant
Autor:
Richard Fruncillo, Steven M. Troy, Lyette S Richards, Geraldine M. Ferron, John Getsy, Jeffrey Paul, Norbert Knebel
Publikováno v:
Journal of clinical pharmacology. 42(2)
Retigabine, a first-in-class selective M-current potassium channel opener, is a novel antiepileptic compound currently in clinical development. The purpose of this randomized placebo-controlled study was to assess retigabine oral safety and pharmacok