Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Norbert Klesel"'
Autor:
Norbert Klesel, Limbert M, Dieter Isert, A. Bauernfeind, Gerhard Seibert, Markus Astrid, E. Eberlein, F Adam, Elmar Dr Schrinner, R. Jungwirth
Publikováno v:
The Journal of Antibiotics. 45:505-520
The aminothiazolyl-cephalosporin RU 29 246 is the active metabolite of the prodrug-pivaloyl-oxyethyl-ester HR 916. RU 29 246 in vitro activity includes a wide range of clinically relevant bacterial pathogens. Against methicillin-sensitive Staphylococ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee01c72c36851b7e3a695a8f47173a80
https://doi.org/10.7164/antibiotics.45.505
https://doi.org/10.7164/antibiotics.45.505
Autor:
Gerhard Seibert, Markus Astrid, Norbert Klesel, Elmar Dr Schrinner, F Adam, Limbert M, Dieter Isert
Publikováno v:
The Journal of Antibiotics. 45:922-931
The pharmacokinetics of the broad spectrum cephem RU 29 246 and its prodrug-ester HR 916 B were investigated in mice, rats and dogs and compared to those of cefpodoxime proxetil, cefuroxime axetil and cefixime. HR 916 B is well absorbed following ora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8700e52a13afa593c18a264bb604de36
https://doi.org/10.7164/antibiotics.45.922
https://doi.org/10.7164/antibiotics.45.922
Autor:
Michael Limbert, Jani Rajendra Kumar Hariprasad, B. N. Ganguli, Norbert Klesel, Dipak Kumar Chatterjee, Gerhard Seibert, J. Blumbach, Sukumar Chatterjee
Publikováno v:
The Journal of Antibiotics. 45:839-845
Mersacidin is a new peptide antibiotic of the proposed lantibiotic family. It is active in vitro and in vivo against Gram-positive bacteria including the methicillin-resistant Staphylococci. Its in vitro activity is less than those of vancomycin and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b06f50f1f8327a800021c0952569f63
https://doi.org/10.7164/antibiotics.45.839
https://doi.org/10.7164/antibiotics.45.839
Publikováno v:
The Journal of Antibiotics. 43:100-106
In systemic and local infections, the therapeutic efficacy of cefpirome was compared to that of imipenem and cefotaxime. Murine septicemia induced with methicillin-sensitive and methicillin-resistant Staphylococcus aureus strains responded well to ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03eb6f9a7f0e81bf2a0ff748df81f22
https://doi.org/10.7164/antibiotics.43.100
https://doi.org/10.7164/antibiotics.43.100
Autor:
Limbert M, Markus Astrid, Elmar Dr Schrinner, R. Jungwirth, T. Wollmann, Norbert Klesel, R. Hakenbeck, Gerhard Seibert, Dieter Isert, R. Wilhelm, A. Bauernfeind
Publikováno v:
The Journal of antibiotics. 45(4)
The aminothiazolyl-cephalosporin RU 29 246, the active metabolite of the prodrug-ester HR 916, is active against strains producing the widespread plasmid-encoded TEM-1, TEM-2 and SHV-1 beta-lactamases. Except for TEM-7 the activity of RU 29 246 again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8ea2e0e952af18f2750bf6e1107680
https://pubmed.ncbi.nlm.nih.gov/1592684
https://pubmed.ncbi.nlm.nih.gov/1592684
Publikováno v:
The Journal of Antibiotics. 37:1712-1718
The activity of the aminothiazolyliminomethoxy cephalosporin cefodizime (HR 221) was compared to that of cefotaxime, cefuroxime and cefazolin in experimental pneumonia caused by Klebsiella pneumoniae DT-S in mice. Cefodizime exhibited high and long-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b85877351735eb30cfff164b0e083b4
https://doi.org/10.7164/antibiotics.37.1712
https://doi.org/10.7164/antibiotics.37.1712
Autor:
Walter Dr. Dürckheimer, Manfred Worm, Gerhard Seibert, Norbert Klesel, Jurgen Blumbach, Jürgen Reden, Karl Heinz Scheunemann, Michael Limbert, Elmar Dr Schrinner, Klaus Fleischmann, Eberhard Ehlers, Manfred Wieduwilt, Mencke Burkhard
Publikováno v:
The Journal of Antibiotics. 40:29-42
The synthesis as well as in vitro antibacterial activity and pharmacokinetic behavior of cefodizime (HR 221, 1a), its analogs and derivatives is described. In this comparison, cefodizime stands out for its balance between its high antibacterial activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1bfd32d8369e895dfa3a6e3b25cf5a
https://doi.org/10.7164/antibiotics.40.29
https://doi.org/10.7164/antibiotics.40.29
Publikováno v:
The Journal of Antibiotics. 40:1762-1767
Cefotaxime (CTX) and HRE 664 (a novel penem antibiotic) possess complementary in vitro properties. Differences can be observed in their antibacterial spectra, their beta-lactamase stability and -inhibition, and their affinity to penicillin-binding pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baced5a67fd1f5c0effa72a3ef63f481
https://doi.org/10.7164/antibiotics.40.1762
https://doi.org/10.7164/antibiotics.40.1762
Publikováno v:
The Journal of antibiotics. 40(8)
The pharmacokinetic and chemotherapeutic properties of the new penem antibiotic HRE 664 (Fig. 1) were evaluated in experimental animals. High and sustained blood and serum levels were achieved following parenteral injection in mice, rats, dogs and mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef1c2a492e17f302183b4b19e3a6a64
https://pubmed.ncbi.nlm.nih.gov/3680029
https://pubmed.ncbi.nlm.nih.gov/3680029
Publikováno v:
The Journal of antibiotics. 37(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5026cc417f97ccf9a7859cf6f15fc761
https://pubmed.ncbi.nlm.nih.gov/6480508
https://pubmed.ncbi.nlm.nih.gov/6480508