The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder

Autor: Cees J. Weeland, Selina Kasprzak, Niels T. de Joode, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Alan Anticevic, Paul D. Arnold, Srinivas Balachander, Nerisa Banaj, Nuria Bargallo, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Vilde Brecke, Silvia Brem, Carolina Cappi, Yuqi Cheng, Kang Ik K. Cho, Daniel L. C. Costa, Sara Dallaspezia, Damiaan Denys, Goi Khia Eng, Sónia Ferreira, Jamie D. Feusner, Martine Fontaine, Jean-Paul Fouche, Rachael G. Grazioplene, Patricia Gruner, Mengxin He, Yoshiyuki Hirano, Marcelo Q. Hoexter, Chaim Huyser, Hao Hu, Fern Jaspers-Fayer, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lazaro, Chiang-shan R. Li, Christine Lochner, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, Jose M. Menchón, Luciano Minnuzi, Pedro Silva Moreira, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Ana E. Ortiz, Jose C. Pariente, John Piacentini, Maria Picó-Pérez, Fabrizio Piras, Federica Piras, Christopher Pittenger, Y. C. Janardhan Reddy, Daniela Rodriguez-Manrique, Yuki Sakai, Eiji Shimizu, Venkataram Shivakumar, Helen Blair Simpson, Noam Soreni, Carles Soriano-Mas, Nuno Sousa, Gianfranco Spalletta, Emily R. Stern, Michael C. Stevens, S. Evelyn Stewart, Philip R. Szeszko, Jumpei Takahashi, Tais Tanamatis, Jinsong Tang, Anders Lillevik Thorsen, David Tolin, Ysbrand D. van der Werf, Hein van Marle, Guido A. van Wingen, Daniela Vecchio, G. Venkatasubramanian, Susanne Walitza, Jicai Wang, Zhen Wang, Anri Watanabe, Lidewij H. Wolters, Xiufeng Xu, Je-Yeon Yun, Qing Zhao, ENIGMA OCD Working Group, Tonya White, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Chris Vriend

Publikováno v: Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD wo

Externí odkaz: https://doaj.org/article/bb65486e4fcd4be1bdc3f13601d6f34a

Polygenic risk for obsessive-compulsive disorder (OCD) predicts brain response during working memory task in OCD, unaffected relatives, and healthy controls

Autor: Stephan Heinzel, Christian Kaufmann, Rosa Grützmann, Julia Klawohn, Anja Riesel, Katharina Bey, Stefanie Heilmann-Heimbach, Leonie Weinhold, Alfredo Ramirez, Michael Wagner, Norbert Kathmann

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Alterations in frontal and parietal neural activations during working memory task performance have been suggested as a candidate endophenotype of obsessive-compulsive disorder (OCD) in studies involving first-degree relatives. However, the d

Externí odkaz: https://doaj.org/article/19edda6e47d94e4e8d34ab02204182a9

Non-invasive brain stimulation modulates neural correlates of performance monitoring in patients with obsessive-compulsive disorder

Autor: Luisa Balzus, Julia Klawohn, Björn Elsner, Sein Schmidt, Stephan A. Brandt, Norbert Kathmann

Publikováno v: NeuroImage: Clinical, Vol 35, Iss , Pp 103113- (2022)

Overactive performance monitoring, as reflected by enhanced neural responses to errors (the error-related negativity, ERN), is considered a biomarker for obsessive-compulsive disorder (OCD) and may be a promising target for novel treatment approaches

Externí odkaz: https://doaj.org/article/59581da1d6aa4605a173365b303f9c02

Spatial working memory performance in people with obsessive–compulsive disorder, their unaffected first-degree relatives and healthy controls

Autor: Stephan Heinzel, Katharina Bey, Rosa Grützmann, Julia Klawohn, Christian Kaufmann, Leonhard Lennertz, Michael Wagner, Norbert Kathmann, Anja Riesel

Publikováno v: BJPsych Open, Vol 7 (2021)

Studies have shown that people with obsessive–compulsive disorder (OCD) have impairments in spatial working memory (SWM) performance. However, it remains unclear whether this deficit represents a cognitive endophenotype preceding symptoms or a corr

Externí odkaz: https://doaj.org/article/008dc87f9cba467dba56cebb26e29bd9

Neural correlates of working memory deficits and associations to response inhibition in obsessive compulsive disorder

Autor: Stephan Heinzel, Christian Kaufmann, Rosa Grützmann, Robert Hummel, Julia Klawohn, Anja Riesel, Katharina Bey, Leonhard Lennertz, Michael Wagner, Norbert Kathmann

Publikováno v: NeuroImage: Clinical, Vol 17, Iss , Pp 426-434 (2018)

Previous research in patients with obsessive-compulsive disorder (OCD) has indicated performance decrements in working memory (WM) and response inhibition. However, underlying neural mechanisms of WM deficits are not well understood to date, and empi

Externí odkaz: https://doaj.org/article/94e0f370ace341499a76af45cfd5b0ab