Antiviral therapy for recurrent hepatitis C after liver transplantation: sustained virologic response is related to genotype 2/3 and response at week 12

Autor: Florian Loehe, Manfred Thiel, Bijan Raziorrouh, Helmut M. Diepolder, Malte H.J. Heeg, Reinhart Zachoval, Carl Albrecht Schirren, Hans Nitschko, Norbert H. Gruener, Maria-Christina Jung, Axel Ulsenheimer

Publikováno v: European Journal of Gastroenterology & Hepatology. 20:778-783

Recurrent hepatitis C virus (HCV) infection after liver transplantation (LT) is a major cause of transplant failure in HCV-positive patients. We retrospectively assessed the efficacy and safety of antiviral therapy and determined the factors influenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb723e1c5b0cb6231a388e29d36af48b
https://doi.org/10.1097/meg.0b013e3282f762f8

Antiviral treatment of recurrent hepatitis C virus (HCV) infection after liver transplantation: association of a strong, multispecific, and long-lasting CD4+ T cell response with HCV-elimination

Autor: Carl Albrecht Schirren, Horst-Guenter Rau, Joern Tilman Gerlach, Gustavo Baretton, Gerd R. Pape, Axel Ulsenheimer, Reinhart Zachoval, Norbert H. Gruener, W. Schraut, Maria-Christina Jung, Hans Nitschko, Helmut M. Diepolder

Publikováno v: Journal of Hepatology. 39:397-404

Patients with recurrent hepatitis C virus (HCV)-infection after liver transplantation (OLTx) could develop an early, multispecific, preferentially intrahepatic CD4+ T cell response. We asked now whether there is a correlation between the HCV-specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76fd37b59985e4b09cd00d4e196b1333
https://doi.org/10.1016/s0168-8278(03)00266-6

Detection of functionally altered hepatitis C virus-specific CD4+ T cells in acute and chronic hepatitis C

Autor: Gerd R. Pape, C.A. Schirren, Helmut M. Diepolder, J. Tilman Gerlach, Axel Ulsenheimer, Reinhart Zachoval, Norbert H. Gruener, W. Schraut, Maria-Christina Jung

Publikováno v: Hepatology. 37:1189-1198

Chronic hepatitis C is characterized by a weak or absent hepatitis C virus (HCV)-specific CD4(+) T-cell response in terms of antigen-specific proliferation or interferon gamma (IFN-gamma) secretion. To clarify whether this is due to the absence or fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b65adb28e5df49e403b0277fb5903d
https://doi.org/10.1053/jhep.2003.50194

Dysfunctional CD8(+) T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction

Autor: Jürgen Haas, Helmut M. Diepolder, Peter Kurktschiev, Michael Spannagl, Markus Backmund, Clemens-Martin Wendtner, Gerald Denk, Norbert H. Gruener, W. Schraut, Maria-Christina Jung, Robert Thimme, Martin Wächtler, Andrea Dick, Bertram Bengsch, Bijan Raziorrouh, Reinhart Zachoval

Publikováno v: Kurktschiev, P D, Raziorrouh, B, Schraut, W, Backmund, M, Waechtler, M, Wendtner, C-M, Bengsch, B, Thimme, R, Denk, G, Zachoval, R, Dick, A, Spannagl, M, Haas, J, Diepolder, H M, Jung, M-C & Gruener, N H 2014, ' Dysfunctional CD8(+) T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction ', Journal of Experimental Medicine, vol. 211, no. 10, pp. 2047-2059 . https://doi.org/10.1084/jem.20131333

The transcription factor T-bet regulates the production of interferon-gamma and cytotoxic molecules in effector CD8 T cells, and its expression correlates with improved control of chronic viral infections. However, the role of T-bet in infections wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096358962e633c69f5d92057a5fe7a22
https://www.pure.ed.ac.uk/ws/files/17909593/Dysfunctional_CD8_T_cells_in_hepatitis_B_and_C_are_characterized_by_a_lack_of_antigen_specific_T_bet_induction.pdf

Cytokine profile of liver- and blood-derived nonspecific T cells after liver transplantation: T helper cells type 1/0 lymphokines dominate in recurrent hepatitis C virus infection and rejection

Autor: Gerd R. Pape, Gustavo Baretton, Maxim Mamin, Helmut M. Diepolder, Norbert H. Gruener, J.T. Gerlach, Maria-Christina Jung, C.A. Schirren, Thomas Worzfeld, Reinhart Zachoval

Publikováno v: Liver Transplantation. 6:222-228

Orthotopic liver transplantation (OLT) is a successful treatment in patients with hepatitis C virus (HCV)-associated end-stage liver disease worldwide. T lymphocytes and their cytokines are believed to have a pivotal role in the defense against HCV a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a684559a2d09aac2a8f9b466360835
https://doi.org/10.1002/lt.500060204