Výsledky vyhledávání - "Norbert G. Knebel"

Pharmacokinetic interaction between retigabine and lamotrigine in healthy subjects

Autor: Robert Hermann, Juergen Borlak, Mathias Locher, Georg Niebch, Norbert G. Knebel, Lyette S Richards

Publikováno v: European Journal of Clinical Pharmacology. 58:795-802

The antiepileptic drugs (AEDs) retigabine (RGB) and lamotrigine (LTG) undergo predominantly N-glucuronidation and renal excretion. This study was performed to evaluate potential pharmacokinetic interactions between both AEDs.Twenty-nine healthy male

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca5a5186c22b800a528fa5fe3485ba9
https://doi.org/10.1007/s00228-003-0558-6

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Effects of age and sex on the disposition of retigabine

Autor: Jeffrey Paul, Norbert G. Knebel, Katharina Erb, Lyette S Richards, Hans‐Peter Cnota, Robert Hermann, Geraldine M. Ferron, Peter Ruus, Steven M. Troy

Publikováno v: Clinical Pharmacology & Therapeutics. 73:61-70

Background The novel antiepileptic drug retigabine is the first selective M-current potassium channel opener for KCNQ2/3 and KCNQ3/5 channels. Retigabine undergoes phase II metabolism (N-glucuronidation, acetylation) exclusively and renal excretion.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f7e9c08dbe3bef91828792b989d4e7
https://doi.org/10.1067/mcp.2003.12

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Effects of miltefosine on various biochemical parameters in a panel of tumor cell lines with different sensitivities 2 2Abbreviations: D-21266, octadecyl-(N,N-dimethyl-piperidino-4-yl)-phosphate; HeLa-WT, HeLa wild-type cells, HeLa-MDR1-G185, HeLa-WT cells transfected with a wild-type MDR1 gene containing glycine in position 185; HeLa-MDR1-V185, HeLa wild-type cells transfected with a mutant MDR1 gene containing valine in position 185; HL-60, human promyelocytic leukemia cells; MDR1, multidrug resistance gene 1; MRP1, multidrug resistance-associated protein; miltefosine, hexadecylphosphocholine; PGP, P-170-glycoprotein; and TMA-DPH, trimethylamino-diphenylhexatriene

Autor: Hans Grunicke, Maria Rybczynska, Johann Hofmann, Martin Spitaler, Günther Boeck, Norbert G Knebel

Publikováno v: Biochemical Pharmacology. 62:765-772

We investigated endocytosis activity, uptake of miltefosine (hexadecylphosphocholine), phospholipid and cholesterol content, the cell cycle, and apoptosis in 13 tumor cell lines (MCF7, MCF7/ADR, KB-3-1, KB-8-5, KB-C1, HeLa, HeLa-MDR1-G185, HeLa-MDR1-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2963ed3a618dd09e1eac48be70c7e25e
https://doi.org/10.1016/s0006-2952(01)00715-8

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Variable disposition kinetics and electrocardiographic effects of flecainide during repeated dosing in humans: Contribution of genetic factors, dose-dependent clearance, and interaction with amiodarone

Autor: Heyo K. Kroemer, Christian Funck-Brentano, Michel Eichelbaum, Patrice Jaillon, Norbert G. Knebel, Kerstin Bühl, Laurent Becquemont

Publikováno v: Clinical Pharmacology and Therapeutics. 55:256-269

We studied the influence of cytochrome P450 2D6 (CYP2D6) on the steady-state disposition kinetics and the electrocardiographic effects of flecainide at two doses and during combination with amiodarone. Seven extensive and five poor metabolizers of de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d666bea6a6bb5519697129934927c0f
https://doi.org/10.1038/clpt.1994.26

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