A high-resolution anatomical atlas of the transcriptome in the mouse embryo.

Autor: Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R Davidson, Pascal Dollé, Stylianos E Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A Baldock, Gregor Eichele, Andrea Ballabio

Publikováno v: PLoS Biology, Vol 9, Iss 1, p e1000582 (2011)

Ascertaining when and where genes are expressed is of crucial importance to understanding or predicting the physiological role of genes and proteins and how they interact to form the complex networks that underlie organ development and function. It i

Externí odkaz: https://doaj.org/article/53f4f9a3fc1a40e48974380ea4a8229d

In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation

Autor: Darío G. Lupiáñez, Acemel Rd, Anania C, Francisca M. Real, Jedamzick J, Kühn R, Adriano Bolondi, Lars Wittler, Norbert Brieske, Giulia Cova

Vertebrate genomes organize into topologically associating domains (TADs), delimited by boundaries that insulate regulatory elements from non-target genes. However, how boundary function is established is not well understood. Here, we combine genome-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d55a854c996585b7fc154c6c905b3e2e
https://doi.org/10.1101/2021.04.14.439779

Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog)

Autor: Wing Lee Chan, Giulia Cova, Marco Osterwalder, Lars Wittler, Norbert Brieske, Martin Vingron, Eva Klopocki, Darío G. Lupiáñez, Jean-Pierre de Villartay, Verena Heinrich, Axel Visel, Stefan Mundlos, Anja J. Will

Publikováno v: Will, AJ; Cova, G; Osterwalder, M; Chan, WL; Wittler, L; Brieske, N; et al.(2017). Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog). Nature Genetics, 49(10), 1539-1545. doi: 10.1038/ng.3939. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/13p9x09q
Nature genetics, vol 49, iss 10
Nature genetics
Nature Genetics

© 2017 Nature America, Inc., part of Springer Nature. All rights reserved. Copy number variations (CNVs) often include noncoding sequences and putative enhancers, but how these rearrangements induce disease is poorly understood. Here we investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d3c6a2e2bcd23749c298ab4f350d96
http://www.escholarship.org/uc/item/13p9x09q

Cloning and expression pattern of chickenRor2and functional characterization of truncating mutations in Brachydactyly type B and Robinow syndrome

Autor: Sigmar Stricker, Norbert Brieske, Kathrin Seidel, Florian Witte, Nicole Verhey van Wijk, Stefan Mundlos

Publikováno v: Developmental Dynamics. 235:3456-3465

Ror2 is a receptor tyrosine kinase mutated in the human syndromes Brachydactyly type B (BDB) and recessive Robinow syndrome (RS). In this study, we used the chick as a model to investigate the role of Ror2 in skeletogenesis and to elucidate the funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a3edc3057db36d13d1201169319d95
https://doi.org/10.1002/dvdy.20993

Human antibody responses to A and C capsular polysaccharides, IgA1 protease and transferrin–binding protein complex stimulated by infection with Neisseria meningitidis of subgroup IV-1 or ET-37 complex

Autor: Thomas Schnibbe, Martin Schenker, Marie-José Quentin-Millet, Norbert Brieske, Mark Achtman

Publikováno v: Vaccine. 17:731-744

The protein sequences of the IgA1 protease, TbpA and TbpB proteins diAer between meningococci representative of serogroup A, subgroup IV-1 from epidemic disease in The Gambia and serogroup C, ET-37 complex from endemic disease in Mali. The uniformity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2fc6252ff663c0ea9916d9fa07e411
https://doi.org/10.1016/s0264-410x(98)00257-6