Nephron deficit is not required for progressive proteinuria development in the Munich Wistar Frömter rat

Autor: Maria Schlesener, Norbert Wendt, Matthias Huber, Kristina Kuhn, Reinhold Kreutz, Peter Kossmehl, Jens R. Nyengaard, Angela Schulz, Jonna Hänsch

Publikováno v: Schulz, A, Hänsch, J, Kuhn, K, Schlesener, M, Kossmehl, P, Nyengaard, J R, Wendt, N, Huber, M & Kreutz, R 2008, ' Nephron deficit is not required for progressive proteinuria development in the Munich Wistar Frömter rat ', Physiological Genomics, vol. 35, no. 1, pp. 30-5 . https://doi.org/10.1152/physiolgenomics.90270.2008

The Munich Wistar Frömter (MWF) rat represents a genetic model with an inherited nephron deficit and exhibits mild hypertension and progressive albuminuria, which is more pronounced in males than females. Previously, we demonstrated in a consomic st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6e22be01bdc4d1542f37031b35e92f
https://doi.org/10.1152/physiolgenomics.90270.2008

Impact of N-Terminal Domains for Corticotropin-Releasing Factor (CRF) Receptor−Ligand Interactions

Autor: Eberhard Krause, Klaus Fechner, Norbert Wendt, Sven Rothemund, Bienert M, Rainer Rudolph, Michael Beyermann, Jana Klose

Publikováno v: Biochemistry. 44:1614-1623

The large extracellular N-terminal domains (NTs) of class B G protein-coupled receptors serve as major ligand binding sites. However, little is known about the ligand requirements for interactions with these receptor domains. Recently, we have shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37844a4a3151fe7aba49a52360217bb0
https://doi.org/10.1021/bi049022e

Protective effect of female gender on the development of albuminuria in a polygenetic rat model is enhanced further by replacement of a major autosomal QTL

Autor: Roland Vetter, Jonna Hänsch, Daniela Grimm, Judith Weiss, Peter Kossmehl, Maria Schlesener, Norbert Wendt, Reinhold Kreutz, Angela Schulz

Publikováno v: Schulz, A, Schlesener, M, Weiss, J, Hänsch, J, Wendt, N, Kossmehl, P, Grimm, D, Vetter, R & Kreutz, R 2008, ' Protective effect of female gender on the development of albuminuria in a polygenetic rat model is enhanced further by replacement of a major autosomal QTL ', Clinical Science, vol. 114, no. 4, pp. 305-11 . https://doi.org/10.1042/CS20070300

Clinical and experimental studies indicate that the progression of renal disease is faster in males than females. These observations are corroborated by a sexual dimorphism observed in the polygenetic MWF (Munich Wistar Frömter) rat model. The age-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4aa0022831e3236242df424c15432e8
https://pure.au.dk/portal/da/publications/protective-effect-of-female-gender-on-the-development-of-albuminuria-in-a-polygenetic-rat-model-is-enhanced-further-by-replacement-of-a-major-autosomal-qtl(fe4d5770-ed24-11dd-8f9a-000ea68e967b).html

Rat chromosome 19 transfer from SHR ameliorates hypertension, salt-sensitivity, cardiovascular and renal organ damage in salt-sensitive Dahl rats

Autor: Anja-Kristin Siegel, Peter Kossmehl, Reinhold Kreutz, Markus Wehland, Judith Weiss, Daniela Grimm, Norbert Wendt, Monika Stoll, Anika Sietmann, Angela Schulz

Publikováno v: Journal of hypertension. 25(1)

Objectives Unlike Dahl salt-sensitive (SS) rats, some strains of spontaneously hypertensive (SHR) rats develop only minor organ damage even when exposed to high-salt diet. In previous linkage studies, we identified quantitative trait loci on rat chro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164ccffe8b9f0eeb4ac8ef18af10bfbc
https://pubmed.ncbi.nlm.nih.gov/17143179

Protective effect of female gender on the development of albuminuria in a polygenetic rat model is enhanced further by replacement of a major autosomal QTL.

Autor: Angela Schulz, Maria Schlesener, Judith Weiss, Jonna Hänsch, Norbert Wendt, Peter Kossmehl, Daniela Grimm, Roland Vetter, Reinhold Kreutz

Publikováno v: Clinical Science; 2008, Vol. 114 Issue 4, p305-311, 7p