Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Norbert Sträter"'
Autor:
Mianling Yang, Myoung Kyu Lee, Shenghua Gao, Letian Song, Hye‐Yeon Jang, Inseong Jo, Chun‐Chiao Yang, Katharina Sylvester, Chunkyu Ko, Shuo Wang, Bing Ye, Kai Tang, Junyi Li, Manyu Gu, Christa E. Müller, Norbert Sträter, Xinyong Liu, Meehyein Kim, Peng Zhan
Publikováno v:
Advanced Science, Vol 11, Iss 43, Pp n/a-n/a (2024)
Abstract The COVID‐19 pandemic has required an expeditious advancement of innovative antiviral drugs. In this study, focused compound libraries are synthesized in 96‐ well plates utilizing modular click chemistry to rapidly discover potent inhibi
Externí odkaz:
https://doaj.org/article/fd9f31fdf8a745a5876e0cf269c69430
Autor:
Rabea Voget, Julian Breidenbach, Tobias Claff, Alexandra Hingst, Katharina Sylvester, Christian Steinebach, Lan Phuong Vu, Renato H. Weiße, Ulrike Bartz, Norbert Sträter, Christa E. Müller, Michael Gütschow
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 5, Pp 2349-2357 (2024)
A titrant for the SARS-CoV-2 main protease (Mpro) was developed that enables, for the first time, the exact determination of the concentration of the enzymatically active Mpro by active-site titration. The covalent binding mode of the tetrapeptidic t
Externí odkaz:
https://doaj.org/article/58da7d67bdec41a39ad53783d3a36b34
Autor:
Tobias Claff, Jonathan G. Schlegel, Jan H. Voss, Victoria J. Vaaßen, Renato H. Weiße, Robert K. Y. Cheng, Sandra Markovic-Mueller, Denis Bucher, Norbert Sträter, Christa E. Müller
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract The Gs protein-coupled adenosine A2A receptor (A2AAR) represents an emerging drug target for cancer immunotherapy. The clinical candidate Etrumadenant was developed as an A2AAR antagonist with ancillary blockade of the A2BAR subtype. It cons
Externí odkaz:
https://doaj.org/article/be5089b2d60c4f06bb110f0f415664ab
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 640 (2024)
Bisphenol A (BPA) and bisphenol B (BPB) are widely used in the production of plastics, and their potential adverse health effects, particularly on endocrine disruption and metabolic health, have raised concern. Peroxisome proliferator-activated recep
Externí odkaz:
https://doaj.org/article/2b301ee2276d4abf82a6c1c87ece2e79
Autor:
P. Konstantin Richter, Paula Blázquez-Sánchez, Ziyue Zhao, Felipe Engelberger, Christian Wiebeler, Georg Künze, Ronny Frank, Dana Krinke, Emanuele Frezzotti, Yuliia Lihanova, Patricia Falkenstein, Jörg Matysik, Wolfgang Zimmermann, Norbert Sträter, Christian Sonnendecker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
The authors describe the cocrystal structure of the highly efficient polyethylene terephthalate-degrading hydrolase PHL7 with its product terephthalic acid and elucidate the role of residues in subsites I and II for its thermal stability and of resid
Externí odkaz:
https://doaj.org/article/8726b0e7f1d64ef0b66aaf1890b28828
Autor:
Joshua D. Frenster, Hediye Erdjument-Bromage, Gabriele Stephan, Niklas Ravn-Boess, Shuai Wang, Wenke Liu, Devin Bready, Jordan Wilcox, Björn Kieslich, Manuel Jankovic, Caroline Wilde, Susanne Horn, Norbert Sträter, Ines Liebscher, Torsten Schöneberg, David Fenyo, Thomas A. Neubert, Dimitris G. Placantonakis
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112679- (2023)
Summary: The adhesion G-protein-coupled receptor GPR133 (ADGRD1) supports growth of the brain malignancy glioblastoma. How the extracellular interactome of GPR133 in glioblastoma modulates signaling remains unknown. Here, we use affinity proteomics t
Externí odkaz:
https://doaj.org/article/a9a9721bc5484f82b98d01af4ebdccdd
Publikováno v:
Environment International, Vol 173, Iss , Pp 107822- (2023)
Di-2-ethylhexyl phthalate (DEHP) and its substitute 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) are widely used as plasticizers but may have adverse health effects. Via hydrolysis of one of the two ester bonds in the human body, DEHP a
Externí odkaz:
https://doaj.org/article/036166b4be46496d9ed0607bb7b3f3cc
Autor:
Elisabeth Jäger, Supriya Murthy, Caroline Schmidt, Magdalena Hahn, Sarah Strobel, Anna Peters, Claudia Stäubert, Pelin Sungur, Tom Venus, Mandy Geisler, Veselina Radusheva, Stefanie Raps, Kathrin Rothe, Roger Scholz, Sebastian Jung, Sylke Wagner, Matthias Pierer, Olga Seifert, Wenhan Chang, Irina Estrela-Lopis, Nora Raulien, Knut Krohn, Norbert Sträter, Stephanie Hoeppener, Torsten Schöneberg, Manuela Rossol, Ulf Wagner
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
How extracellular calcium can trigger Nlrp3 inflammasome activation has been somewhat controversial and unclear. Here the authors show calciprotein particles are taken up by myeloid cells via calcium-sensing receptor-dependent macropinocytosis in res
Externí odkaz:
https://doaj.org/article/13285a5fc1104c3ea401a9b5df22ded9
Autor:
Shenghua Gao, Letian Song, Tobias Claff, Molly Woodson, Katharina Sylvester, Lanlan Jing, Renato H. Weiße, Yusen Cheng, Norbert Sträter, Laura Schäkel, Michael Gütschow, Bing Ye, Mianling Yang, Tao Zhang, Dongwei Kang, Karoly Toth, John Tavis, Ann E. Tollefson, Christa E. Müller, Peng Zhan, Xinyong Liu
Publikováno v:
Journal of Medicinal Chemistry. 65:16902-16917
The spread of SARS-CoV-2 keeps threatening human life and health, and small-molecule antivirals are in demand. The main protease (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271ca8882f9f7b9c5ad53b93c3b5bbee
https://doi.org/10.1021/acs.jmedchem.2c01716
https://doi.org/10.1021/acs.jmedchem.2c01716
Autor:
Laura Heiligenthal, Marie van der Loh, Matthias Polack, Maximilian E. Blaha, Susanne Moschütz, Antje Keim, Norbert Sträter, Detlev Belder
Publikováno v:
Analytical and Bioanalytical Chemistry. 414:6977-6987
Microfluidic double-emulsion droplets allow the realization and study of biphasic chemical processes such as chemical reactions or extractions on the nanoliter scale. Double emulsions of the rare type (o1/w/o2) are used here to realize a lipase-catal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54f90bba12e5220db7d7cdc7d2b54cf
https://doi.org/10.1007/s00216-022-04266-2
https://doi.org/10.1007/s00216-022-04266-2