Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Norbert, Szentandrássy"'
Autor:
Balázs Horváth, Zsigmond Kovács, Csaba Dienes, Zalán Barta, József Óvári, Norbert Szentandrássy, János Magyar, Tamás Bányász, Péter P. Nánási
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Current density, the membrane current value divided by membrane capacitance (Cm), is widely used in cellular electrophysiology. Comparing current densities obtained in different cell populations assume that Cm and ion current magnitudes are
Externí odkaz:
https://doaj.org/article/8371437791444a409019823d2d96291b
Autor:
Zsigmond Máté Kovács, József Óvári, Csaba Dienes, János Magyar, Tamás Bányász, Péter P. Nánási, Balázs Horváth, Adam Feher, Zoltan Varga, Norbert Szentandrássy
Publikováno v:
Pharmaceuticals, Vol 17, Iss 9, p 1137 (2024)
Text Correction [...]
Externí odkaz:
https://doaj.org/article/a16bc3d92c6e4da99b9481e5b95c5636
Autor:
Arnold Péter Ráduly, Attila Tóth, Fruzsina Sárkány, Balázs Horváth, Norbert Szentandrássy, Péter P. Nánási, Zoltán Csanádi, István Édes, Zoltán Papp, Attila Borbély
Publikováno v:
ESC Heart Failure, Vol 10, Iss 2, Pp 1326-1335 (2023)
Abstract Aims Heart failure with reduced ejection fraction (HFrEF) is a disease with high mortality and morbidity. Recent positive inotropic drug developments focused on cardiac myofilaments, that is, direct activators of the myosin molecule and Ca2+
Externí odkaz:
https://doaj.org/article/884f94be9dcb4a8dbf784c50e3b45f24
Autor:
Muhammad Naveed, Aiman Saleh A. Mohammed, Leila Topal, Zsigmond Máté Kovács, Csaba Dienes, József Ovári, Norbert Szentandrássy, János Magyar, Tamás Bányász, János Prorok, Norbert Jost, László Virág, István Baczkó, András Varró, Péter P. Nánási, Balázs Horváth
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2383 (2023)
The present study was designed to test the hypothesis that the selectivity of blocking the late Na+ current (INaL) over the peak Na+ current (INaP) is related to the fast offset kinetics of the Na+ channel inhibitor. Therefore, the effects of 1 µM G
Externí odkaz:
https://doaj.org/article/4d6e1b0b3ba44596a4eb96b73ed834ff
Autor:
Tamás Hézső, Muhammad Naveed, Csaba Dienes, Dénes Kiss, János Prorok, Tamás Árpádffy-Lovas, Richárd Varga, Erika Fujii, Tanju Mercan, Leila Topal, Kornél Kistamás, Norbert Szentandrássy, János Almássy, Norbert Jost, János Magyar, Tamás Bányász, István Baczkó, András Varró, Péter P. Nánási, László Virág, Balázs Horváth
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Enhancement of the late Na+ current (INaL) increases arrhythmia propensity in the heart, while suppression of the current is antiarrhythmic. GS967 is an agent considered as a selective blocker of INaL. In the present study, effects of GS967
Externí odkaz:
https://doaj.org/article/73d50e33846d4bc7818bb17c0e8b0687
Autor:
Balázs Horváth, Zsigmond M. Kovács, Csaba Dienes, József Óvári, Norbert Szentandrássy, János Magyar, Tamás Bányász, András Varró, Péter P. Nánási
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 560 (2023)
Late sodium current (INa,late) is an important inward current contributing to the plateau phase of the action potential (AP) in the mammalian heart. Although INa,late is considered as a possible target for antiarrhythmic agents, several aspects of th
Externí odkaz:
https://doaj.org/article/9adbb159c8874d7fbddaf3d9033c1e89
Autor:
Zsigmond Máté Kovács, József Óvári, Csaba Dienes, János Magyar, Tamás Bányász, Péter P. Nánási, Balázs Horváth, Adam Feher, Zoltan Varga, Norbert Szentandrássy
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 488 (2023)
ABT-333 (dasabuvir) is an antiviral agent used in hepatitis C treatment. The molecule, similarly to some inhibitors of hERG channels, responsible for the delayed rectifier potassium current (IKr), contains the methanesulfonamide group. Reduced IKr cu
Externí odkaz:
https://doaj.org/article/4969770aed67445f99b626397d6c0a4b
Autor:
Balázs Horváth, Norbert Szentandrássy, Csaba Dienes, Zsigmond M. Kovács, Péter P. Nánási, Ye Chen-Izu, Leighton T. Izu, Tamas Banyasz
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The patch clamp technique underwent continual advancement and developed numerous variants in cardiac electrophysiology since its introduction in the late 1970s. In the beginning, the capability of the technique was limited to recording one single cur
Externí odkaz:
https://doaj.org/article/5a6d3cd79aa44352a76be3308cc0e474
Autor:
Arnold Péter Ráduly, Fruzsina Sárkány, Máté Balázs Kovács, Brigitta Bernát, Béla Juhász, Zoltán Szilvássy, Róbert Porszász, Balázs Horváth, Norbert Szentandrássy, Péter Nánási, Zoltán Csanádi, István Édes, Attila Tóth, Zoltán Papp, Dániel Priksz, Attila Borbély
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 446 (2022)
Recent cardiotropic drug developments have focused on cardiac myofilaments. Danicamtiv, the second direct myosin activator, has achieved encouraging results in preclinical and clinical studies, thus implicating its potential applicability in the trea
Externí odkaz:
https://doaj.org/article/4b2de420989c4ff5b80e581d50e817b3
Autor:
Norbert Szentandrássy, Zsuzsanna É. Magyar, Judit Hevesi, Tamás Bányász, Péter P. Nánási, János Almássy
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 8, p 4435 (2022)
Cardiac diseases are the leading causes of death, with a growing number of cases worldwide, posing a challenge for both healthcare and research. Therefore, the most relevant aim of cardiac research is to unravel the molecular pathomechanisms and iden
Externí odkaz:
https://doaj.org/article/7d4bb3896bbb48febaf920a71135b3af