Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Norbert, Redemann"'
Autor:
Holger Fuchs, Birgit Stierstorfer, Remko A. Bakker, Carina M. Weigelt, Tanja Schönberger, Norbert Redemann, Thomas Ciossek, Benjamin Strobel, Thorsten Lamla
Publikováno v:
Translational Vision Science & Technology
Purpose Retinopathies display complex pathologies, including vasculopathies, inflammation, and fibrosis, leading ultimately to visual impairment. However, animal models accurately reflecting these pathologies are lacking. In this study, we evaluate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a293ad7e4a08311a0277c46b5b4a924
https://doi.org/10.1167/tvst.10.11.15
https://doi.org/10.1167/tvst.10.11.15
Autor:
Carola Kleiner, Frank H. Büttner, Martin Winter, Tom Bretschneider, Norbert Redemann, Daniel Bischoff, Robert Ries, Andreas H. Luippold, Jörg P Hehn
Publikováno v:
SLAS discovery : advancing life sciences RD. 23(6)
Label-free, mass spectrometric (MS) detection is an emerging technology in the field of drug discovery. Unbiased deciphering of enzymatic reactions is a proficient advantage over conventional label-based readouts suffering from compound interference
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76468e6e9a7c91b23bd6e5a45c8e23a
https://pubmed.ncbi.nlm.nih.gov/29466676
https://pubmed.ncbi.nlm.nih.gov/29466676
Autor:
Elisabeth Kulenkampff, Heike Neubauer, Carla Rudigier, Norbert Redemann, Gerd Luippold, Christian Wolfrum, Aliki Perdikari
Publikováno v:
Science signaling. 10(466)
Brown adipose tissue (BAT) is responsible for thermogenesis that is not associated with shivering through the process of converting chemical energy into heat through uncoupling protein 1 (UCP1) in the mitochondria. Thus, expanding or activating BAT c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96dbb2cb7cb6e97090e3c8bd3a98f12
https://pubmed.ncbi.nlm.nih.gov/28196906
https://pubmed.ncbi.nlm.nih.gov/28196906
Publikováno v:
Journal of Molecular Biology. 426:843-852
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is associated with autosomal dominant hypercholesterolemia, a state of elevated levels of LDL (low-density lipoprotein) cholesterol. Autosomal dominant hypercholesterolemia can result in severe im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1dcbb2f412d0289a1537b31d1d3ee7
https://doi.org/10.1016/j.jmb.2013.11.011
https://doi.org/10.1016/j.jmb.2013.11.011
Publikováno v:
FEBS Letters. 581:5885-5890
Inhibition of the lipid phosphatase SH2-domain containing inositol phosphatase 2 (SHIP2) in L6-C10 muscle cells, in 3T3-L1 adipocytes and in the liver of db/db mice has been shown to ameliorate insulin signal transduction and established SHIP2 as a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df5a9a3ae15de01fe4517a36af5b75e
https://doi.org/10.1016/j.febslet.2007.11.066
https://doi.org/10.1016/j.febslet.2007.11.066
Autor:
Corinna Schoelch, Norbert Redemann, Darya Zibrova, Joerg F. Rippmann, Rolf Grempler, André van Marle
Publikováno v:
Diabetes. 56:2235-2241
Type 2 diabetes is characterized by a progressive resistance of peripheral tissues to insulin. Recent data have established the lipid phosphatase SH2 domain–containing inositol phosphatase 2 (SHIP2) as a critical negative regulator of insulin signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6df33d52e4721745af7f844bb7fa3235
https://doi.org/10.2337/db06-1660
https://doi.org/10.2337/db06-1660
Publikováno v:
Oncogene. 20:4198-4208
Hematopoietic cytokines are critically required for survival and cell proliferation of myeloid and erythroid progenitors. It is poorly understood how the apoptotic machinery of progenitor cells senses the absence of specific cytokines. Here we show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82537a7b11db5dc7a9357dd6b639689c
https://doi.org/10.1038/sj.onc.1204550
https://doi.org/10.1038/sj.onc.1204550
Publikováno v:
ChemInform. 43
Based on a high-throughput screening, cyclopentanecarboxanilides (I) are identified as a new chemotype of non-covalent inhibitors of type 1 fatty acid synthase (FAS).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab9bab4068aefe0d5f2380263dc8e8be
https://doi.org/10.1002/chin.201208219
https://doi.org/10.1002/chin.201208219
Publikováno v:
Bioorganic & Medicinal Chemistry Letters.
Based on a high-throughput screen, cyclopentanecarboxanilides were identified as a new chemotype of non-covalent inhibitors of type I fatty acid synthase (FAS). Starting from initial hits we aimed at generating a tool compound suitable for the in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8a43e15ab3ee3dde46ee6871fa7ff4
https://doi.org/10.1016/j.bmcl.2011.07.083
https://doi.org/10.1016/j.bmcl.2011.07.083
Autor:
Rolf, Grempler, Darya, Zibrova, Corinna, Schoelch, André, van Marle, Joerg F, Rippmann, Norbert, Redemann
Publikováno v:
Diabetes. 56(9)
Type 2 diabetes is characterized by a progressive resistance of peripheral tissues to insulin. Recent data have established the lipid phosphatase SH2 domain-containing inositol phosphatase 2 (SHIP2) as a critical negative regulator of insulin signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bfc85771a685eaf1793705a940ba221e
https://pubmed.ncbi.nlm.nih.gov/17596404
https://pubmed.ncbi.nlm.nih.gov/17596404