Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Norah M. E. Fogarty"'
Autor:
Liani Devito, Afshan N. Malik, Preeti Khurana, Nikola Kolundzic, Vladimir M. Jovanović, Norah M. E. Fogarty, Dusko Ilic, Russell A. Foulk, Shirin Elizabeth Khorsandi, Hannah S. Rosa, Kathy K. Niakan, Gnanaratnam Giritharan, Caroline Mackie Ogilvie, Mohammad Saleh Ardawi, Laila Noli, Nigel Heaton, Patrick F. Chinnery, Angela Pyle, Yacoub Khalaf, Aleksandra Cvoro, Antonio Capalbo
Publikováno v:
Stem Cells (Dayton, Ohio)
Thyroid hormones are regarded as the major controllers of metabolic rate and oxygen consumption in mammals. Although it has been demonstrated that thyroid hormone supplementation improves bovine embryo development in vitro, the cellular mechanisms un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e660a3bd86eab1311bd44bf6f8832b
https://doi.org/10.1002/stem.3129
https://doi.org/10.1002/stem.3129
Autor:
Leila Christie, Phil Snell, Alice E. Chen, Paul Blakeley, Rabi Odia, Kathy K. Niakan, Kay Elder, Mahesh Sangrithi, Prabhakaran Munusamy, Ahmed Abdelbaki, Paul Serhal, Norah M. E. Fogarty, Liani G. Devito, Afshan McCarthy
During the first week of development, human embryos form a blastocyst comprised of an inner cell mass and trophectoderm (TE) cells, the latter of which are progenitors of placental trophoblast. Here we investigated the expression of transcripts in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e18df636cea561abfa01e07ed3978a74
https://doi.org/10.1101/2021.08.18.456785
https://doi.org/10.1101/2021.08.18.456785
Autor:
Afshan McCarthy, Kathy K. Niakan, Gregorio Alanis-Lobato, Dagan Wells, Jasmin Zohren, Maria Greco, Emily Hardman, James M. A. Turner, Norah M. E. Fogarty, N Kubikova
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences
CRISPR-Cas9 genome editing is a promising technique for clinical applications, such as the correction of disease-associated alleles in somatic cells. The use of this approach has also been discussed in the context of heritable editing of the human ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e76a506d5ade59622fead1f539df2f5
https://europepmc.org/articles/PMC8179174/
https://europepmc.org/articles/PMC8179174/
Autor:
Claudia Gerri, Norah M. E. Fogarty, Alexandre Bruneau, Afshan McCarthy, Kathy K. Niakan, Phil Snell, Laurent David, Andrej Demtschenko, Daniel Hampshire, Leila Christie, Sophie Loubersac, Gregorio Alanis-Lobato, Ali A. Fouladi-Nashta, Kay Elder, Hilde Van De Velde
Publikováno v:
Nature
Current understandings of cell specification in early mammalian pre-implantation development are based mainly on mouse studies. The first lineage differentiation event occurs at the morula stage, with outer cells initiating a trophectoderm (TE) place
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf10137eb1af7c8f17a20c6a96e8391
https://europepmc.org/articles/PMC7116563/
https://europepmc.org/articles/PMC7116563/
Autor:
Maria Greco, James M. A. Turner, Afshan McCarthy, Dagan Wells, Gregorio Alanis-Lobato, Kathy K. Niakan, N Kubikova, Norah M. E. Fogarty, Jasmin Zohren, Emily Hardman
CRISPR-Cas9 genome editing is a promising technique for clinical applications, such as the correction of disease-associated alleles in somatic cells. The use of this approach has also been discussed in the context of heritable editing of the human ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0432b7c163e274cee215c820b2d9a7b5
https://doi.org/10.1101/2020.06.05.135913
https://doi.org/10.1101/2020.06.05.135913
Autor:
Benjamin E. Powell, Jens Kleinjung, Rebecca A. Lea, James M. A. Turner, Alessandro Bertero, Kay Elder, Paul Blakeley, Ludovic Vallier, Kathy K. Niakan, Dagan Wells, Kirsten E. Snijders, N Kubikova, Daesik Kim, Valdone Maciulyte, Afshan McCarthy, Norah M. E. Fogarty, Sissy E. Wamaitha, Jin-Soo Kim
Publikováno v:
Fogarty, N M E, McCarthy, A, Snijders, K E, Powell, B E, Kubikova, N, Blakeley, P, Lea, R, Elder, K, Wamaitha, S E, Kim, D, Maciulyte, V, Kleinjung, J, Kim, J S, Wells, D, Vallier, L, Bertero, A, Turner, J M A & Niakan, K K 2017, ' Genome editing reveals a role for OCT4 in human embryogenesis ', Nature, vol. 550, no. 7674, pp. 67-73 . https://doi.org/10.1038/nature24033
Despite their fundamental biological and clinical importance, the molecular mechanisms that regulate the first cell fate decisions in the human embryo are not well understood. Here we use CRISPR-Cas9-mediated genome editing to investigate the functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c39201df2ae54555fa54787f2f4ee7b
https://doi.org/10.1038/nature24033
https://doi.org/10.1038/nature24033
Autor:
Paul Blakeley, Lyndsey Craven, Mary Herbert, Helen A. L. Tuppen, Douglass M. Turnbull, Laura Irving, Sissy E. Wamaitha, Louise Hyslop, Qi Zhang, Meenakshi Choudhary, Mahdi Lamb, Elpida Fragouli, Samer Alfarawati, Dagan Wells, Kathy K. Niakan, Jessica Richardson, Yuko Takeda, Nilendran Prathalingam, Alison Murdoch, Lucia Arizzi, Hannah O’Keefe, Norah M. E. Fogarty, Dimitrios Kalleas
Publikováno v:
Nature
Hyslop, L A, Blakeley, P, Craven, L, Richardson, J, Fogarty, N M E, Fragouli, E, Lamb, M, Wamaitha, S E, Prathalingam, N, Zhang, Q, O'Keefe, H, Takeda, Y, Arizzi, L, Alfarawati, S, Tuppen, H A, Irving, L, Kalleas, D, Choudhary, M, Wells, D, Murdoch, A P, Turnbull, D M, Niakan, K K & Herbert, M 2016, ' Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease ', Nature, vol. 534, no. 7607, pp. 383-386 . https://doi.org/10.1038/nature18303
Hyslop, L A, Blakeley, P, Craven, L, Richardson, J, Fogarty, N M E, Fragouli, E, Lamb, M, Wamaitha, S E, Prathalingam, N, Zhang, Q, O'Keefe, H, Takeda, Y, Arizzi, L, Alfarawati, S, Tuppen, H A, Irving, L, Kalleas, D, Choudhary, M, Wells, D, Murdoch, A P, Turnbull, D M, Niakan, K K & Herbert, M 2016, ' Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease ', Nature, vol. 534, no. 7607, pp. 383-386 . https://doi.org/10.1038/nature18303
Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a broad range of debilitating and fatal diseases. Reproductive technologies designed to uncouple the inheritance of mtDNA from nuclear DNA may enable affected women
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4b178fb12857ffbbfc46bb3f4ea7c4
http://europepmc.org/articles/PMC5131843
http://europepmc.org/articles/PMC5131843
Autor:
Tereza, Cindrova-Davies, Norah M E, Fogarty, Carolyn J P, Jones, John, Kingdom, Graham J, Burton
Publikováno v:
Placenta
Introduction Premature ageing has been implicated in placental dysfunction. Senescence can be activated by oxidative stress, a key intermediary in the pathophysiology of pre-eclampsia. We examined senescence markers across normal gestation, and in pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::60006fc77366057e01e437db53e656d6
https://pubmed.ncbi.nlm.nih.gov/30055665
https://pubmed.ncbi.nlm.nih.gov/30055665
Autor:
Hongkai Ji, Paul Blakeley, Yingying Wei, Richard I. Sherwood, Kathy K. Niakan, Ignacio del Valle, Sissy E. Wamaitha, Norah M. E. Fogarty, Lily T. Y. Cho
Publikováno v:
Genes & Development. 29:1239-1255
Transcription factor-mediated reprograming is a powerful method to study cell fate changes. In this study, we demonstrate that the transcription factor Gata6 can initiate reprograming of multiple cell types to induced extraembryonic endoderm stem (iX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a56ca912e9115db97733c0c3c038f4
https://doi.org/10.1101/gad.257071.114
https://doi.org/10.1101/gad.257071.114