Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Norah K. Algarzae"'
Publikováno v:
Frontiers in Dementia, Vol 3 (2024)
Tyrosine kinases (TKs) are catalytic enzymes activated by auto-phosphorylation that function by phosphorylating tyrosine residues on downstream substrates. Tyrosine kinase inhibitors (TKIs) have been heavily exploited as cancer therapeutics, primaril
Externí odkaz:
https://doaj.org/article/601d1668ad0c41dcb9694638345e5985
Autor:
Hanan K. AlGhibiwi, Wedad S. Sarawi, Manal E. Alosaimi, Ahlam M. Alhusaini, Mohammed A. Assiri, Norah K. Algarzae
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 10, Iss 9, p 358 (2023)
Background: Traditional modifiable cardiovascular risk factors, such as high blood pressure, have long been positively correlated with high carotid intima-media thickness (cIMT). However, traditional cardiovascular risk factors made a minor contribut
Externí odkaz:
https://doaj.org/article/d8013664a191472a913f824c3a7bf1c5
Autor:
Nicole M. Desforges, Michaeline L. Hebron, Norah K. Algarzae, Irina Lonskaya, Charbel E.-H. Moussa
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2012 (2012)
The role of inflammation in neurodegenerative diseases has been widely demonstrated. Intraneuronal protein accumulation may regulate microglial activity via the fractalkine (CX3CL1) signaling pathway that provides a mechanism through which neurons co
Externí odkaz:
https://doaj.org/article/55e4843ff7b844b9b97d84adce2460d5
Publikováno v:
Experimental Neurology. 251:127-138
Tau hyper-phosphorylation (p-Tau) and neuro-inflammation are hallmarks of neurodegeneration. Previous findings suggest that microglial activation via CX3CL1 promotes p-Tau. We examined inflammation and autophagic p-Tau clearance in lentiviral Tau and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de2c9c7be6f02bdbd167e3aedb3f2d2
https://doi.org/10.1016/j.expneurol.2013.01.009
https://doi.org/10.1016/j.expneurol.2013.01.009
Publikováno v:
Neuroscience. 232:90-105
Parkinson's disease (PD) is a motor disorder that involves death of dopaminergic neurons in the substantia nigra pars compacta. Parkin is an autosomal recessive gene that is mutated in early onset PD. We investigated the role of parkin and autophagic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67aa50cf236aae51a71e2b9c9abe0d9
https://doi.org/10.1016/j.neuroscience.2012.12.018
https://doi.org/10.1016/j.neuroscience.2012.12.018
Publikováno v:
Neuroscience. 225:22-34
Alzheimer’s disease (AD) is a neurodegenerative aging disorder characterized by extracellular Aβ plaques and intraneuronal neurofibrillary tangles. We conducted longitudinal studies to examine the effects of Aβ on brain amino acid metabolism in l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e24263dfe0cae81cf8f315e8b37dbbe
https://doi.org/10.1016/j.neuroscience.2012.08.057
https://doi.org/10.1016/j.neuroscience.2012.08.057
Autor:
Norah K. Algarzae, Michaeline Hebron, Kaydee Sharpe, Ashot R. Shekoyan, Irina Lonskaya, Puwakdandawe P.K. Weerasinghe, Charbel Moussa
The importance of E3 ubiquitin ligases, involved in the degradation of misfolded proteins or promotion of protein-protein interaction, is increasingly recognized in neurodegeneration. TDP-43 is a predominantly nuclear protein, which regulates the tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50624f67d55a6f1b1e820cf69b640ed
https://europepmc.org/articles/PMC3567661/
https://europepmc.org/articles/PMC3567661/
Autor:
Ashot R. Shekoyan, Norah K. Algarzae, Nicole M. Desforges, Irina Lonskaya, Charbel Moussa, Michaeline Hebron
Publikováno v:
Journal of Alzheimer's disease : JAD. 33(1)
Alzheimer's disease (AD) is an aging disorder characterized by amyloid-β (Aβ) accumulation in extracellular plaques and formation of intracellular tangles containing hyperphosphorylated tau (p-Tau). Autophagic defects, leading to accumulation of au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba24a5e5a629ffd082e8c1b080d77bb2
https://pubmed.ncbi.nlm.nih.gov/22954671
https://pubmed.ncbi.nlm.nih.gov/22954671
Publikováno v:
International Journal of Alzheimer's Disease
International Journal of Alzheimer's Disease, Vol 2012 (2012)
International Journal of Alzheimer's Disease, Vol 2012 (2012)
The role of inflammation in neurodegenerative diseases has been widely demonstrated. Intraneuronal protein accumulation may regulate microglial activity via the fractalkine (CX3CL1) signaling pathway that provides a mechanism through which neurons co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1726f82774f92cc17b4c1165610ec50e
http://europepmc.org/articles/PMC3420133
http://europepmc.org/articles/PMC3420133