Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Norah A, Owiti"'
Autor:
Robert S Rogers, Hong Wang, Timothy J Durham, Jonathan A Stefely, Norah A Owiti, Andrew L Markhard, Lev Sandler, Tsz-Leung To, Vamsi K Mootha
Publikováno v:
PLoS Biology, Vol 21, Iss 5, p e3002117 (2023)
There is widespread interest in identifying interventions that extend healthy lifespan. Chronic continuous hypoxia delays the onset of replicative senescence in cultured cells and extends lifespan in yeast, nematodes, and fruit flies. Here, we asked
Externí odkaz:
https://doaj.org/article/56d5adc8ffd44d2ca1e52f0708949c87
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11776 (2022)
The comet assay is a versatile assay for detecting DNA damage in eukaryotic cells. The assay can measure the levels of various types of damage, including DNA strand breaks, abasic sites and alkali-sensitive sites. Furthermore, the assay can also be m
Externí odkaz:
https://doaj.org/article/4ddaee3200fd432bbf746fbf0abc7945
Autor:
Norah A, Owiti, Simran, Kaushal, Lincoln, Martin, Jamie, Sly, Carol D, Swartz, Jasmine, Fowler, Joshua J, Corrigan, Les, Recio, Bevin P, Engelward
Publikováno v:
Current Protocols. 2
Exposure to DNA damaging agents can lead to mutations that cause cancer. The liver is particularly vulnerable because it contains high levels of Cytochrome P450 enzymes that can convert xenobiotics into DNA reactive metabolites that form potentially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6231d6520e79c91b248c4f32698cdaa9
https://doi.org/10.1002/cpz1.563
https://doi.org/10.1002/cpz1.563
Publikováno v:
Trends Cancer
DNA damage can lead to carcinogenic mutations and to toxicity that promotes diseases. Therefore, having rapid assays to quantify DNA damage, DNA repair, mutations, and cytotoxicity is broadly relevant to health. For example, DNA damage assays can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11831b3c59abdc75a94e0a999b81e04
https://pubmed.ncbi.nlm.nih.gov/33203608
https://pubmed.ncbi.nlm.nih.gov/33203608
Autor:
Cheng Zheng, Jenny Kay, Jong Park, Zachary D. Nagel, Norah A. Owiti, Bevin P. Engelward, Christy Chao, Dushan N. Wadduwage, Peter T. C. So
Publikováno v:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVIII.
We propose a high-throughput 3D imaging cytometer for fast quantification of DNA double strand break (DSB) frequency in cells for DNA damage study. With structured illumination enabled depth contrast and a fast focus tunable lens enabled scanning, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aab668f341e6a1fb019d05db1444a2d4
https://doi.org/10.1117/12.2546302
https://doi.org/10.1117/12.2546302
Autor:
Leona D. Samson, John Winters, Carol D. Swartz, Aoli Xiong, Norah A. Owiti, Jongyoon Han, Jing Ge, Le P. Ngo, Yang Su, Leslie Recio, Bevin P. Engelward
Publikováno v:
Nucleic Acids Research
Genotoxicity testing is critical for predicting adverse effects of pharmaceutical, industrial, and environmental chemicals. The alkaline comet assay is an established method for detecting DNA strand breaks, however, the assay does not detect potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724ad2eda4b52af72cb481769e39dc06
http://europepmc.org/articles/PMC7026589
http://europepmc.org/articles/PMC7026589
Autor:
Norah A. Owiti, Larry Coffer, Alan L. Myers, Xue Zhang, Lata Mathew, Judith A. Smith, Jonathan P. Faro
Publikováno v:
Journal of Integrative Oncology.
Background: The evaluation of active hexose correlated compound (AHCC) on hepatic metabolism mediateddrug interaction is critical in current clinical setting as there is little published information on the potential effect on drug efficacy and safety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65803da2622e950932ac2cdc6152f582
https://doi.org/10.4172/2329-6771.1000142
https://doi.org/10.4172/2329-6771.1000142