Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nora Vazquez-Laslop"'
Autor:
Egor A. Syroegin, Laurin Flemmich, Dorota Klepacki, Nora Vazquez-Laslop, Ronald Micura, Yury S. Polikanov
Publikováno v:
Nat Struct Mol Biol
Ribosome-targeting antibiotics serve as powerful antimicrobials and as tools for studying the ribosome, the catalytic peptidyl transferase center (PTC) of which is targeted by many drugs. The classic PTC-acting antibiotic chloramphenicol (CHL) and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baec779b058957314915defbfc42a2e8
https://europepmc.org/articles/PMC9071271/
https://europepmc.org/articles/PMC9071271/
Autor:
Alexander S. Mankin, Amira Kefi, Sarah Colon, Teresa Szal, Tyler J Brown, Terry W. Moore, Vallari Shah, Nora Vazquez-Laslop, Chetana Baliga, Kornelia J. Skowron, Dorota Klepacki, Tanja Florin
Publikováno v:
Proc Natl Acad Sci U S A
Apidaecin (Api), an unmodified 18-amino-acid-long proline-rich antibacterial peptide produced by bees, has been recently described as a specific inhibitor of translation termination. It invades the nascent peptide exit tunnel of the postrelease ribos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a29bde975acc2abaee0e565a6e27223
Autor:
Alexander S. Mankin, Dorota Klepacki, Olga Krasnykh, Debbie C. Mulhearn, Scott G. Franzblau, Haripriya Ramu, Nora Vazquez-Laslop
Publikováno v:
Proceedings of the National Academy of Sciences. 108:10496-10501
Specific nascent peptides in the ribosome exit tunnel can elicit translation arrest. Such ribosome stalling is used for regulation of expression of some bacterial and eukaryotic genes. The stalling is sensitive to additional cellular cues, most commo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3aec78ae92f4ec3d1dd012ea67580a
https://doi.org/10.1073/pnas.1103474108
https://doi.org/10.1073/pnas.1103474108
Autor:
Anne-Xander van der Stel, Emily R. Gordon, Arnab Sengupta, Allyson K. Martínez, Dorota Klepacki, Thomas N. Perry, Alba Herrero del Valle, Nora Vázquez-Laslop, Matthew S. Sachs, Luis R. Cruz-Vera, C. Axel Innis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Bacteria adjust the expression of some of their metabolic enzymes through metabolite-sensing ribosome nascent chain complexes. Here the authors present a cryo-EM structure of an E. coli ribosome stalled during translation of the TnaC leader peptide a
Externí odkaz:
https://doaj.org/article/99346a81e0d045cab5ff4b2e4b54f7d9
Autor:
Bertrand Beckert, Elodie C. Leroy, Shanmugapriya Sothiselvam, Lars V. Bock, Maxim S. Svetlov, Michael Graf, Stefan Arenz, Maha Abdelshahid, Britta Seip, Helmut Grubmüller, Alexander S. Mankin, C. Axel Innis, Nora Vázquez-Laslop, Daniel N. Wilson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Macrolides and ketolides antibiotics selectively interfere with the translation of a specific subset of proteins. Here the authors show how the macrolide erythromycin and the ketolide telithromycin interplay with the nascent polypeptide chain to arre
Externí odkaz:
https://doaj.org/article/15117e74a84f4129bf14254d7d049216
Autor:
Irina Laczkovich, Kyle Mangano, Xinhao Shao, Adam J. Hockenberry, Yu Gao, Alexander Mankin, Nora Vázquez-Laslop, Michael J. Federle
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Streptococcus pneumoniae, an opportunistic human pathogen, is the leading cause of community-acquired pneumonia and an agent of otitis media, septicemia, and meningitis. Although genomic and transcriptomic studies of S. pneumoniae have provi
Externí odkaz:
https://doaj.org/article/f4394a0dfc874f73a61901fee1d4e8a3
Publikováno v:
Molecular microbiology. 71(4)
The ribosome has the intrinsic capacity to monitor the sequence and structure of the nascent peptide. This fundamental property of the ribosome is often exploited in regulation of gene expression, in particular, for activation of expression of genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e556825151fc774118aee59b7c14609
https://pubmed.ncbi.nlm.nih.gov/19170872
https://pubmed.ncbi.nlm.nih.gov/19170872
Autor:
Maxim S. Svetlov, Timm O. Koller, Sezen Meydan, Vaishnavi Shankar, Dorota Klepacki, Norbert Polacek, Nicholas R. Guydosh, Nora Vázquez-Laslop, Daniel N. Wilson, Alexander S. Mankin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Macrolide antibiotics inhibit bacterial translation in a context-specific manner, arresting ribosomes at defined sites within mRNAs and selectively inhibiting synthesis of only a subset of cellular proteins. Here the authors provide a structural basi
Externí odkaz:
https://doaj.org/article/494f279037aa4f0d861c4a268dfa4d94
Autor:
Shijie Huang, Nikolay A. Aleksashin, Anna B. Loveland, Dorota Klepacki, Kaspar Reier, Amira Kefi, Teresa Szal, Jaanus Remme, Luc Jaeger, Nora Vázquez-Laslop, Andrei A. Korostelev, Alexander S. Mankin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Ribosomes of all organisms have retained 5S rRNA as an autonomous rRNA species. Here the authors engineer a bacterial strain with ribosomes that do not have free 5S rRNA, and carry structural analyses that suggest the evolutionary preservation of 5S
Externí odkaz:
https://doaj.org/article/97ce74dddff14abd9b4d20a9c96f526d
Autor:
Nikolay A. Aleksashin, Teresa Szal, Anne E. d’Aquino, Michael C. Jewett, Nora Vázquez-Laslop, Alexander S. Mankin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Ribosome engineering is an emerging powerful approach for synthetic protein synthesis. Here the authors invert the Ribo-T system, using the engineered ribosome to translate the proteome while the native ribosome translates specific mRNA.
Externí odkaz:
https://doaj.org/article/2fa4b8a9829c4319b8a0ec1c4381a811