Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Nora Vázquez-Laslop"'
Autor:
Anne-Xander van der Stel, Emily R. Gordon, Arnab Sengupta, Allyson K. Martínez, Dorota Klepacki, Thomas N. Perry, Alba Herrero del Valle, Nora Vázquez-Laslop, Matthew S. Sachs, Luis R. Cruz-Vera, C. Axel Innis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Bacteria adjust the expression of some of their metabolic enzymes through metabolite-sensing ribosome nascent chain complexes. Here the authors present a cryo-EM structure of an E. coli ribosome stalled during translation of the TnaC leader peptide a
Externí odkaz:
https://doaj.org/article/99346a81e0d045cab5ff4b2e4b54f7d9
Autor:
Irina Laczkovich, Kyle Mangano, Xinhao Shao, Adam J. Hockenberry, Yu Gao, Alexander Mankin, Nora Vázquez-Laslop, Michael J. Federle
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Streptococcus pneumoniae, an opportunistic human pathogen, is the leading cause of community-acquired pneumonia and an agent of otitis media, septicemia, and meningitis. Although genomic and transcriptomic studies of S. pneumoniae have provi
Externí odkaz:
https://doaj.org/article/f4394a0dfc874f73a61901fee1d4e8a3
Autor:
Bertrand Beckert, Elodie C. Leroy, Shanmugapriya Sothiselvam, Lars V. Bock, Maxim S. Svetlov, Michael Graf, Stefan Arenz, Maha Abdelshahid, Britta Seip, Helmut Grubmüller, Alexander S. Mankin, C. Axel Innis, Nora Vázquez-Laslop, Daniel N. Wilson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Macrolides and ketolides antibiotics selectively interfere with the translation of a specific subset of proteins. Here the authors show how the macrolide erythromycin and the ketolide telithromycin interplay with the nascent polypeptide chain to arre
Externí odkaz:
https://doaj.org/article/15117e74a84f4129bf14254d7d049216
Autor:
Maxim S. Svetlov, Timm O. Koller, Sezen Meydan, Vaishnavi Shankar, Dorota Klepacki, Norbert Polacek, Nicholas R. Guydosh, Nora Vázquez-Laslop, Daniel N. Wilson, Alexander S. Mankin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Macrolide antibiotics inhibit bacterial translation in a context-specific manner, arresting ribosomes at defined sites within mRNAs and selectively inhibiting synthesis of only a subset of cellular proteins. Here the authors provide a structural basi
Externí odkaz:
https://doaj.org/article/494f279037aa4f0d861c4a268dfa4d94
Autor:
Shijie Huang, Nikolay A. Aleksashin, Anna B. Loveland, Dorota Klepacki, Kaspar Reier, Amira Kefi, Teresa Szal, Jaanus Remme, Luc Jaeger, Nora Vázquez-Laslop, Andrei A. Korostelev, Alexander S. Mankin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Ribosomes of all organisms have retained 5S rRNA as an autonomous rRNA species. Here the authors engineer a bacterial strain with ribosomes that do not have free 5S rRNA, and carry structural analyses that suggest the evolutionary preservation of 5S
Externí odkaz:
https://doaj.org/article/97ce74dddff14abd9b4d20a9c96f526d
Autor:
Nikolay A. Aleksashin, Teresa Szal, Anne E. d’Aquino, Michael C. Jewett, Nora Vázquez-Laslop, Alexander S. Mankin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Ribosome engineering is an emerging powerful approach for synthetic protein synthesis. Here the authors invert the Ribo-T system, using the engineered ribosome to translate the proteome while the native ribosome translates specific mRNA.
Externí odkaz:
https://doaj.org/article/2fa4b8a9829c4319b8a0ec1c4381a811
Autor:
Nikolay A. Aleksashin, Margus Leppik, Adam J. Hockenberry, Dorota Klepacki, Nora Vázquez-Laslop, Michael C. Jewett, Jaanus Remme, Alexander S. Mankin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The tethered ribosome system Ribo-T supports cell proliferation though at a reduced rate. Here the authors show this is due to slower ribosome assembly instead of reduced functionality.
Externí odkaz:
https://doaj.org/article/dd41dd2510804c7598e1969fe536f5bc
Autor:
Kyle Mangano, Tanja Florin, Xinhao Shao, Dorota Klepacki, Irina Chelysheva, Zoya Ignatova, Yu Gao, Alexander S Mankin, Nora Vázquez-Laslop
Publikováno v:
eLife, Vol 9 (2020)
Biochemical studies suggested that the antimicrobial peptide apidaecin (Api) inhibits protein synthesis by binding in the nascent peptide exit tunnel and trapping the release factor associated with a terminating ribosome. The mode of Api action in ba
Externí odkaz:
https://doaj.org/article/9e38722b3a344e0cacd910a2f28a93ea
Autor:
Shanmugapriya Sothiselvam, Sandro Neuner, Lukas Rigger, Dorota Klepacki, Ronald Micura, Nora Vázquez-Laslop, Alexander S. Mankin
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1789-1799 (2016)
Macrolide antibiotic binding to the ribosome inhibits catalysis of peptide bond formation between specific donor and acceptor substrates. Why particular reactions are problematic for the macrolide-bound ribosome remains unclear. Using comprehensive m
Externí odkaz:
https://doaj.org/article/5de8ece61be24c608cf1c9d5672577a1
Autor:
Kyle Mangano, Dorota Klepacki, Irueosa Ohanmu, Chetana Baliga, Weiping Huang, Alexandra Brakel, Andor Krizsan, Yury S. Polikanov, Ralf Hoffmann, Nora Vázquez-Laslop, Alexander S. Mankin
Publikováno v:
Nature Chemical Biology.