A Single Amino Acid Residue Regulates PTEN-Binding and Stability of the Spinal Muscular Atrophy Protein SMN

Autor: Sebastian Rademacher, Nora T. Detering, Tobias Schüning, Robert Lindner, Pamela Santonicola, Inga-Maria Wefel, Janina Dehus, Lisa M. Walter, Hella Brinkmann, Agathe Niewienda, Katharina Janek, Miguel A. Varela, Melissa Bowerman, Elia Di Schiavi, Peter Claus

Publikováno v: Cells, Vol 9, Iss 11, p 2405 (2020)

Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by decreased levels of the survival of motoneuron (SMN) protein. Post-translational mechanisms for regulation of its stability are still elusive. Thus, we aimed to identify regulatory ph

Externí odkaz: https://doaj.org/article/7097473dd94a440e803af1b7c34e2a24

A Single Amino Acid Residue Regulates PTEN-Binding and Stability of the Spinal Muscular Atrophy Protein SMN.

Autor: Rademacher, Sebastian¹ (AUTHOR) sebastian.rademacher@charite.de, Detering, Nora T.^1,2 (AUTHOR) Detering.Nora@mh-hannover.de, Schüning, Tobias^1,2 (AUTHOR) Schuening.Tobias@mh-hannover.de, Lindner, Robert¹ (AUTHOR) Lindner.Robert@mh-hannover.de, Santonicola, Pamela³ (AUTHOR) pamela.santonicola@ibbr.cnr.it, Wefel, Inga-Maria¹ (AUTHOR) i-m.wefel@web.de, Dehus, Janina¹ (AUTHOR) Janina.Dehus@web.de, Walter, Lisa M.^1,2 (AUTHOR) l.walter-enzen@t-online.de, Brinkmann, Hella¹ (AUTHOR) Brinkmann.Hella@mh-hannover.de, Niewienda, Agathe⁴ (AUTHOR) agathe.niewienda@charite.de, Janek, Katharina⁴ (AUTHOR) katharina.janek@charite.de, Varela, Miguel A.^5,6 (AUTHOR) miguel.varela@dpag.ox.ac.uk, Bowerman, Melissa^5,7,8 (AUTHOR) m.bowerman@keele.ac.uk, Di Schiavi, Elia³ (AUTHOR) elia.dischiavi@ibbr.cnr.it, Claus, Peter^1,2 (AUTHOR) claus.peter@mh-hannover.de

Publikováno v: Cells (2073-4409). Nov2020, Vol. 9 Issue 11, p2405. 1p.