Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Nora S. Kula"'
Autor:
Ross J. Baldessarini, Robert B. Innis, Mohammed S. Al-Tikriti, Ronald M. Baldwin, Frederic Bois, Julie K. Staley, Gilles Tamagnan, Nora S. Kula, Louis Amici
Publikováno v:
Nuclear Medicine and Biology. 35:53-59
To develop a potential SPECT probe to evaluate the integrity of the serotoninergic system (5-HTT) whose dysfunction is linked to several disease conditions such as Parkinson's disease, Alzheimer's disease and depression, we report the synthesis, radi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d28158344be1009a3993788cadea38
https://doi.org/10.1016/j.nucmedbio.2007.09.002
https://doi.org/10.1016/j.nucmedbio.2007.09.002
Autor:
Perry F. Renshaw, Nora S. Kula, John L. Neumeyer, Marc J. Kaufman, Ross J. Baldessarini, Ao Zhang, Kehong Zhang
Publikováno v:
Letters in Drug Design & Discovery. 2:302-306
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::067580727fb88576596a17884473c77e
https://doi.org/10.2174/1570180054038332
https://doi.org/10.2174/1570180054038332
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 306:1145-1151
Levels of ionotropic glutamate (Glu) N-methyl-d-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kainic acid (KA) receptors in rat forebrain regions were compared by quantitative in vitro receptor autoradiography
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5fa0c1f97ada853b7d81924754f2826
https://doi.org/10.1124/jpet.103.052597
https://doi.org/10.1124/jpet.103.052597
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:3049-3053
A series of novel fluoroalkyl-containing tropane derivatives was synthesized, and their binding affinities for the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET) were determined via competitive binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8b261b64cb8621dfd785217fc1e88c
https://doi.org/10.1016/s0960-894x(01)00626-6
https://doi.org/10.1016/s0960-894x(01)00626-6
Autor:
Ross J. Baldessarini, Alexander Campbell, Nora S. Kula, Victor E. Shashoua, James G. Flood, Matthews O. Bradley, S. Hemamalini, Nigel L. Webb, Charles S. Swindell
Publikováno v:
Neuropsychopharmacology. 24:55-65
Stable amides of clozapine derived from fatty acids prominent in cerebral tissue might enhance the central activity of clozapine and reduce its exposure to peripheral tissues. Such derivatives might enhance the safety of this unique drug, which is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e479099988948dcd08c59824400dcd
https://doi.org/10.1016/s0893-133x(00)00173-1
https://doi.org/10.1016/s0893-133x(00)00173-1
Publikováno v:
NeuroReport. 8:3423-3426
BINDING of the D 2 -like (D 2 /D 3 /D 4 ) radioligand [ 3 H]nemonapride under selective conditions (with 300 nM S[-]-raclopride and other masking agents to occlude D 2 /D 3 receptors and non-specific binding sites) revealed a subset of raclopride-ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b374812a285c4c6930f88975d80df12b
https://doi.org/10.1097/00001756-199711100-00001
https://doi.org/10.1097/00001756-199711100-00001
Publikováno v:
Drug Discovery Today. 2:333-340
Novel dopamine (DA) receptor proteins of relatively low natural abundance and uncertain physiology can be expressed selectively in genetically transfected cultured cells to facilitate screening of novel DA receptor ligands. Selective agonists or anta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2512d2c1b79f4ae43eaf1c9a6df48a2c
https://doi.org/10.1016/s1359-6446(97)01075-1
https://doi.org/10.1016/s1359-6446(97)01075-1
Publikováno v:
Pharmacology Biochemistry and Behavior. 56:251-259
Bilateral local microinfusion of serotonin (5-hydroxytryptamine; 5-HT) into the ventrolateral striatum (VLS) of the rat forebrain induces quantifiable stereotyped orofacial behaviors. The role of presynaptic dopamine (DA) and structural requirements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00074d91b444f120a64dd287de9aeae
https://doi.org/10.1016/s0091-3057(96)00217-1
https://doi.org/10.1016/s0091-3057(96)00217-1
Autor:
Nora S. Kula, Gilles Tamagnan, Yigong Gao, John L. Neumeyer, Shaoyin Wang, Ross J. Baldessarini
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:337-340
A series of novel N-phthalimidoalkyl analogs of the stable phenyltropane β-CIT were synthesized and evaluated by selective radioligand binding assays for affinity to transporters for dopamine (DA), serotonin (5-HT) and norepinephrine (NE) in corpus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7ca91c81d9c58643887da7a88a18fe1
https://doi.org/10.1016/s0960-894x(97)00009-7
https://doi.org/10.1016/s0960-894x(97)00009-7
Autor:
John L. Neumeyer, Ross J. Baldessarini, Shaoyin Wang, Yigong Gao, Gilles Tamagnan, Nora S. Kula, Richard A Milius
Publikováno v:
Journal of Medicinal Chemistry. 39:543-548
This report concerns the synthesis and chemical characterization of novel series of N-substituted 2 beta-carbomethoxy-3 beta-(4'-iodophenyl)tropane (beta-CIT, 2) analogs and their neuropharmacological evaluation for affinity at dopamine (DAT), seroto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c196cb73b1f065e908f007898abcc5b6
https://doi.org/10.1021/jm9505324
https://doi.org/10.1021/jm9505324