Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Nora S. Green"'
1
Synthesis and Characterization of Potent Bivalent Amyloidosis Inhibitors That Bind Prior to Transthyretin Tetramerization
Autor: Nora S. Green, James C. Sacchettini, Satheesh K. Palaninathan, Jeffery W. Kelly
Publikováno v: Journal of the American Chemical Society. 125:13404-13414
The misfolding of transthyretin (TTR), including rate-limiting tetramer dissociation and partial monomer denaturation, is sufficient for TTR misassembly into amyloid and other abnormal quaternary structures associated with senile systemic amyloidosis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c364c90b3b1336eb0f9155e4bee81969
https://doi.org/10.1021/ja030294z
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2
Stereoelectronic, Torsional, and Steric Effects on Rates of Enolization of Ketones
Autor: Kaori Ando, Shahdad E. Behnam, and Nora S. Green, Kendall N. Houk, Shahrad M. Behnam
Publikováno v: The Journal of Organic Chemistry. 65:8970-8978
The stereoselectivities of base-catalyzed enolizations of ketones have been studied by quantum mechanical methods. Transition structures of exo and endo deprotonation of camphor, norcamphor, and dehydronorcamphor have been located with two model base
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c75ae436b7bb91ca32b41011e65bbc
https://doi.org/10.1021/jo000905v
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4
Native State Kinetic Stabilization as a Strategy to Ameliorate Protein Misfolding Diseases: A Focus on the Transthyretin Amyloidoses
Autor: Yoshiki Sekijima, Steven M. Johnson, R. Luke Wiseman, Nora S. Green, Jeffery W. Kelly, Sara L. Adamski-Werner
Publikováno v: ChemInform. 37
Small molecule-mediated protein stabilization inside or outside of the cell is a promising strategy to treat protein misfolding/misassembly diseases. Herein we focus on the transthyretin (TTR) amyloidoses and demonstrate that preferential ligand bind
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5a248f63c2370ea0e128d508822503
https://doi.org/10.1002/chin.200614266
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5
Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis
Autor: Ted R. Foss, Jeffery W. Kelly, Nora S. Green
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 102(41)
The misfolding of transthyretin (TTR), including rate-limiting tetramer dissociation and partial monomer denaturation, is sufficient for TTR misassembly into amyloid and other abnormal quaternary structures associated with three amyloid diseases: sen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8996754355b5cdb1daa7932a18d28ba6
https://pubmed.ncbi.nlm.nih.gov/16195386
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6
Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis
Autor: R. Luke Wiseman, Nora S. Green, Jeffery W. Kelly
Publikováno v: Biochemistry. 44(25)
Kinetic stabilization of transthyretin (TTR) is established to prevent human neurodegeneration. Therefore, small molecule-mediated kinetic stabilization of the native state is an attractive strategy to prevent the misfolding and misassembly associate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4bdff48e66bfda2694896f9e0bd2fc3
https://pubmed.ncbi.nlm.nih.gov/15966751
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7
Quantitative evaluation of the lengths of homobifunctional protein cross-linking reagents used as molecular rulers
Autor: Emil Reisler, Nora S. Green, Kendall N. Houk
Publikováno v: Protein science : a publication of the Protein Society. 10(7)
Homobifunctional chemical cross-linking reagents are important tools for functional and structural characterization of proteins. Accurate measures of the lengths of these molecules currently are not available, despite their widespread use. Stochastic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84659401d166b745d71e535988ca2436
https://pubmed.ncbi.nlm.nih.gov/11420431
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9
Chemically synthesized peptides of hepatitis B surface antigen duplicate the d/y specificities and induce subtype-specific antibodies in chimpanzees
Autor: George Dapolito, Richard A. Lerner, Hannah Alexander, Nora S. Green, Thomas M. Shinnick, James Wai-Kuo Shih, Ronald E. Engle, J G Sutcliffe, John L. Gerin, Robert H. Purcell
Publikováno v: Proceedings of the National Academy of Sciences. 80:2365-2369
Synthetic peptides, predicted from the nucleotide sequence of the S gene of hepatitis B virus were analyzed in terms of the established specificities of the hepatitis B surface antigen. The analysis indicated that the group-specific alpha antigen is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0865120c54a8a2dabbe936573e6cca4
https://doi.org/10.1073/pnas.80.8.2365
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10
Sequence-specific antibodies show that maturation of Moloney leukemia virus envelope polyprotein involves removal of a COOH-terminal peptide
Autor: Richard A. Lerner, J G Sutcliffe, Alfred S. Ponticelli, Nora S. Green, Thomas M. Shinnick, Owen N. Witte
Publikováno v: Proceedings of the National Academy of Sciences. 78:6023-6027
We followed maturation of the glycosylated envelope polyprotein Pr80env of a murine retrovirus by using antisera specific to subregions of the protein, including an antiserum directed against a synthetic peptide corresponding to the COOH-terminus of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5f089cb9590414a90272ea6c93550e
https://doi.org/10.1073/pnas.78.10.6023
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