Výsledky vyhledávání - "Nora Philbin"

Akademický článek

Shock Index and Prediction of Traumatic Hemorrhagic Shock 28-Day Mortality: Data from the DCLHb Resuscitation Clinical Trials

Autor: Edward P. Sloan, Max Koenigsberg, James M. Clark, William B. Weir, Nora Philbin

Publikováno v: Western Journal of Emergency Medicine, Vol 15, Iss 7, Pp 795-802 (2014)

Introduction: To assess the ability of the shock index (SI) to predict 28-day mortality in traumatic hemorrhagic shock patients treated in the diaspirin cross-linked hemoglobin (DCLHb) resuscitation clinical trials. Methods: We used data from two

Externí odkaz: https://doaj.org/article/b658dbab4bb744f28bb00fec71101480

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RESUSCITATION WITH THE HEMOGLOBIN-BASED OXYGEN CARRIER, HBOC-201, IN A SWINE MODEL OF SEVERE UNCONTROLLED HEMORRHAGE AND TRAUMATIC BRAIN INJURY

Autor: Francoise Arnaud, Gerald McGwin, Daniel Freilich, Susan A. Stern, L. Bruce Pearce, Nora Philbin, W. Shannon Flournoy, Richard M. McCarron, Jennifer Rice, Todd Johnson, Stephen T. Ahlers

Publikováno v: Shock. 31:64-79

The purpose of this investigation was to compare the effects of initial resuscitation with HBOC-201 to that of lactated Ringer (LR) solution in the setting of uncontrolled hemorrhage and traumatic brain injury (TBI). Anesthetized immature swine under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45673a4dac1d49b48f1c3877cb16225f
https://doi.org/10.1097/shk.0b013e3181778dc3

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The Effects of Decreasing Low-Molecular Weight Hemoglobin Components of Hemoglobin-Based Oxygen Carriers in Swine With Hemorrhagic Shock

Autor: Daniel Freilich, Richard M. McCarron, Virginia T. Rentko, Sarah Collier, Paula Moon-Massatt, Thomas Steinbach, Rick Light, Michael Handrigan, L. Bruce Pearce, Nora Philbin, Jennifer Rice, Nina Malkevich, Francoise Arnaud, Gerry McGwin, Stephen T. Ahlers

Publikováno v: Journal of Trauma: Injury, Infection & Critical Care. 64:1240-1257

Background: Some hemoglobin-based oxygen carriers (HBOCs) improve outcome in animal models of hemorrhagic shock (HS) in comparison with standard asanguinous resuscitation fluids. Nevertheless, concern about intrinsic vasoactivity, linked in part to l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27c224aad0c6b62bd3fad972adac229
https://doi.org/10.1097/ta.0b013e318058245e

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Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care

Autor: Daniel Freilich, Richard M. McCarron, Francoise Arnaud, Nora Philbin, Stephen T. Ahlers, Daniel Fasipe, W. Shannon Flournoy, Jennifer Rice

Publikováno v: Transfusion. 47:2098-2109

BACKGROUND: The hemoglobin-based oxygen carrier (HBOC-201) resuscitation fluid improves outcome in hemorrhagic shock swine models with minimal coagulopathy. Herein, coagulation parameters were evaluated after resuscitation with HBOC-201 after severe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8978c7ccfd8380adc6935cfd1d88f5f6
https://doi.org/10.1111/j.1537-2995.2007.01435.x

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Resuscitation following severe, controlled hemorrhage associated with a 24h delay to surgical intervention in swine using a hemoglobin based oxygen carrier as an oxygen bridge to definitive care

Autor: Kyle McNickle, Richard M. McCarron, Nora Philbin, Rita Williams, Mathew Warndorf, Francoise Arnaud, Daniel Freilich, Nina Malkevich, Gerald McGwin, Jennifer Rice, Michael Handrigan

Publikováno v: Resuscitation. 74:332-343

To test our hypothesis that the hemoglobin based oxygen carrier HBOC-201 would have similar or superior efficacy to 6% hetastarch (HEX) as a pre-hospital 'bridging' fluid for hemorrhagic shock when delay to definitive medical care is prolonged to 24h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0695f1d2cf6fecb83fd00936dee758
https://doi.org/10.1016/j.resuscitation.2006.12.018

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Innate Immune Responses in Swine Resuscitated from Severe Traumatic Hemorrhagic Shock with Hemoglobin-Based Oxygen Carrier-201

Autor: Daniel Freilich, Michael Handrigan, Carrie H. Hall, W. S. Flournoy, Gerald McGwin, Stephen T. Ahlers, F. Aranaud, Frank Dong, Richard M. McCarron, Nora Philbin, Nina Malkevich, Jennifer Rice, C. VanderMolen, Jiang Hong, L. Bruce Pearce

Publikováno v: Artificial Cells, Blood Substitutes, and Biotechnology. 35:259-274

Hemoglobin-based oxygen carrier-201 transports oxygen and improves survival in swine with hemorrhagic shock, but has potential to be immune activating. Herein, we evaluated HBOC-201's immune effects in swine with more severe hemorrhagic shock due to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d03240a11a3d5001818a834b820b9ec
https://doi.org/10.1080/10731190701378568

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Immune Effects of Decreasing Low-Molecular Weight Hemoglobin Components of Hemoglobin-Based Oxygen Carriers (HBOC) in a Swine Model of Severe Controlled Hemorrhagic Shock

Autor: Daniel Freilich, C. VanderMolen, Richard M. McCarron, Jennifer Rice, S. Collier, Gerald McGwin, Stephen T. Ahlers, Nora Philbin, Nina Malkevich, L. Bruce Pearce, Carrie H. Hall

Publikováno v: Artificial Cells, Blood Substitutes, and Biotechnology. 35:507-517

Hemoglobin-based oxygen carriers (HBOCs) show potential as safe, efficacious, pre-hospital resuscitation fluids. The major criticism of HBOC-201 is its vasoactive property, attributed partially to low-molecular weight (low-MW) tetrameric/dimeric (TD)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396cebf2f22f63abc24845d6fb047128
https://doi.org/10.1080/10731190701586228

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Coagulation patterns following haemoglobin-based oxygen carrier resuscitation in severe uncontrolled haemorrhagic shock in swine

Autor: Michael Hammett, Nora Philbin, Frank Dong, Richard M. McCarron, Francoise Arnaud, Daniel Freilich, Jennifer Rice, L. B. Pearce, Michael Handrigan

Publikováno v: Transfusion Medicine. 16:290-302

Massive blood loss due to penetrating trauma and internal organ damage can cause severe haemorrhagic shock (HS), leading to a severely compromised haemostatic balance. This study evaluated the effect of bovine polymerized haemoglobin (Hb) (Hb-based o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72fae2d3cd0a9aceb8c0b04eeb611c6
https://doi.org/10.1111/j.1365-3148.2006.00678.x

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Resuscitation from Hemorrhagic Shock: Fluid Selection and Infusion Strategy Drives Unmeasured Ion Genesis

Autor: Feng Dong, Daniel Freilich, Francoise Arnaud, Lewis J. Kaplan, Nora Philbin, Jennifer Rice

Publikováno v: The Journal of Trauma: Injury, Infection, and Critical Care. 61:90-98

This study compares unmeasured ion generation by different resuscitation fluids and strategies for hemorrhagic shock (HS).A rectus crush injury and 40% hemorrhage initiated controlled HS in 24 minipigs. Pigs (n = 8/gp) were untreated (NON) or bolused

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5eecc6d47956afee1a7e0a87355f29
https://doi.org/10.1097/01.ta.0000222578.85413.4e

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