Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nora Pauwels"'
Autor:
Jing Wang, Joren Guillaume, Nora Pauwels, Serge Van Calenbergh, Ildiko Van Rhijn, Dirk M Zajonc
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47989 (2012)
NKT cells play important roles in immune surveillance. They rapidly respond to pathogens by detecting microbial glycolipids when presented by the non-classical MHC I homolog CD1d. Previously, ruminants were considered to lack NKT cells due to the lac
Externí odkaz:
https://doaj.org/article/914f7c6e533f40abbf91d79b05dc7400
Autor:
Joren Guillaume, Dirk Elewaut, Nora Pauwels, Sandrine Aspeslagh, Dirk M. Zajonc, Serge Van Calenbergh
Publikováno v:
BIOORGANIC & MEDICINAL CHEMISTRY
Alpha-galactosyl ceramide (α-GalCer) is a prototypical synthetic ligand of invariant natural killer T (iNKT) cells. Upon presentation by the MHC class I-like molecule CD1d, this glycolipid stimulates iNKT cells to secrete a vast amount of both pro-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6497502e5a3999f5624f254e349f110d
https://doi.org/10.1016/j.bmc.2015.04.068
https://doi.org/10.1016/j.bmc.2015.04.068
Autor:
Sampada Chitale, Esther Dawen Yu, Amy R. Howell, Richard W. Franck, Marek Nemčovič, Moriya Tsuji, Dirk M. Zajonc, Mitchell Kronenberg, Serge Van Calenbergh, Jing Wang, Archana Khurana, Enrico Girardi, Nora Pauwels, Elisa Farber, Alysia Birkholz
Publikováno v:
JOURNAL OF BIOLOGICAL CHEMISTRY
The ability of different glycosphingolipids (GSLs) to activate type I natural killer T cells (NKT cells) has been known for 2 decades. The possible therapeutic use of these GSLs has been studied in many ways; however, studies are needed in which the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db7a67358a35340db7585f153e94736f
https://doi.org/10.1074/jbc.m115.654814
https://doi.org/10.1074/jbc.m115.654814
Publikováno v:
BIOORGANIC & MEDICINAL CHEMISTRY
We report the synthesis of a small series of 6"-triazol-1-yl-substituted α-GalCer analogues by late-stage conversion of the 6"-OH to an azide group, copper-catalyzed azide-alkyne cycloaddition and final deprotection. When evaluated for their capacit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbff980302a2172b479f59c5efa7474
https://doi.org/10.1016/j.bmc.2012.09.063
https://doi.org/10.1016/j.bmc.2012.09.063
Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis
Autor:
Serge Van Calenbergh, Michael B. Drennan, Dirk Elewaut, Yali Li, Richard W. Franck, Dirk M. Zajonc, Katrien Van Beneden, Nora Pauwels, Koen Venken, Jing Wang, Esther Dawen Yu, Enrico Girardi, Tine Decruy, Matthias Trappeniers, Luc Leybaert, Sandrine Aspeslagh
Publikováno v:
The EMBO Journal. 30:2294-2305
Invariant natural killer T (iNKT) cells are known to have marked immunomodulatory capacity due to their ability to produce copious amounts of effector cytokines. Here, we report the structure and function of a novel class of aromatic α-galactosylcer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5857da8a5a3288534f6d9114c8a0a0fb
https://doi.org/10.1038/emboj.2011.145
https://doi.org/10.1038/emboj.2011.145
Autor:
Nora Pauwels, Jing Wang, Dirk M. Zajonc, Serge Van Calenbergh, Marek Nemčovič, Dirk Elewaut, Sandrine Aspeslagh, Koen Venken
Publikováno v:
JOURNAL OF IMMUNOLOGY
NKT cells, a unique type of regulatory T cells, respond to structurally diverse glycolipids presented by CD1d. Although it was previously thought that recognition of glycolipids such as α-galactosylceramide (α-GalCer) by the NKT cell TCR (NKTCR) ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95042a9a96b660fd0c444abaa9651c07
https://pubmed.ncbi.nlm.nih.gov/23960235
https://pubmed.ncbi.nlm.nih.gov/23960235
Autor:
Joren Guillaume, Serge Van Calenbergh, Ildiko Van Rhijn, Nora Pauwels, Dirk M. Zajonc, Jing Wang
Publikováno v:
PLoS One, 7(10). Public Library of Science
PLoS ONE, Vol 7, Iss 10, p e47989 (2012)
PLOS ONE
PLoS ONE
PLoS ONE, Vol 7, Iss 10, p e47989 (2012)
PLOS ONE
PLoS ONE
NKT cells play important roles in immune surveillance. They rapidly respond to pathogens by detecting microbial glycolipids when presented by the non-classical MHC I homolog CD1d. Previously, ruminants were considered to lack NKT cells due to the lac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34fcbc2b07562d117fb86cc6dd839399
https://doi.org/10.1371/journal.pone.0047989
https://doi.org/10.1371/journal.pone.0047989
Autor:
Esther Dawen Yu, Serge Van Calenbergh, Dirk Elewaut, Gerd Vanhoenacker, Bruno Linclau, Koen Sandra, Dirk M. Zajonc, Nora Pauwels, Sandrine Aspeslagh
A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6′′-OH and the sphingosine amino groups, which enables convenient synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ef48fcff5f6c82f8afdbafbd110624
https://hdl.handle.net/20.500.14017/34c61581-26d6-4670-bc4d-6bddfea16255
https://hdl.handle.net/20.500.14017/34c61581-26d6-4670-bc4d-6bddfea16255
Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis
Autor:
Sandrine, Aspeslagh, Yali, Li, Esther Dawen, Yu, Nora, Pauwels, Matthias, Trappeniers, Enrico, Girardi, Tine, Decruy, Katrien, Van Beneden, Koen, Venken, Michael, Drennan, Luc, Leybaert, Jing, Wang, Richard W, Franck, Serge, Van Calenbergh, Dirk M, Zajonc, Dirk, Elewaut
Publikováno v:
The EMBO journal. 30(11)
Invariant natural killer T (iNKT) cells are known to have marked immunomodulatory capacity due to their ability to produce copious amounts of effector cytokines. Here, we report the structure and function of a novel class of aromatic α-galactosylcer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4be8089c12b59904b61b5f2f2d9cbcfe
https://pubmed.ncbi.nlm.nih.gov/21552205
https://pubmed.ncbi.nlm.nih.gov/21552205
Autor:
Sandrine Aspeslagh, Yali Li, Esther Yu, Tine Decruy, Katrien Van Beneden, Enrico Girardi, Nora Pauwels, Matthias Trappeniers, Koen Venken, Michael Drennan, Luc Leybaert, Jing Wang, Serge Van Calenbergh, Dirk Zajonc, Dirk Elewaut
Publikováno v:
The Journal of Immunology. 186:156.4-156.4
Invariant natural killer T cells are known to have marked immunomodulatory capacity due to their ability to produce copious amounts of effector cytokines. In this study, we report the first crystal structures of a novel class of strong Th1 biasing st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2829a2945a67d206d944687822b1d81
https://doi.org/10.4049/jimmunol.186.supp.156.4
https://doi.org/10.4049/jimmunol.186.supp.156.4